Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(12), P. 549 - 549
Published: Dec. 4, 2024
The
green
synthesis
of
silver
(Ag)
and
zinc
oxide
(ZnO)
nanoparticles
(NPs),
as
well
Ag/Ag2O/ZnO
nanocomposites
(NCs),
using
polar
apolar
extracts
Chlorella
vulgaris,
offers
a
sustainable
method
for
producing
nanomaterials
with
tunable
properties.
impact
the
environment
nanomaterials’
characteristics
on
cytotoxicity
was
evaluated
by
examining
reactive
species
production
their
effects
mitochondrial
bioenergetic
functions.
Cytotoxicity
assays
PC12
cells,
cell
line
originated
from
rat
pheochromocytoma,
an
adrenal
medulla
tumor,
demonstrated
that
Ag/Ag2O
NPs
synthesized
(Ag/Ag2O
A)
P)
exhibited
significant
cytotoxic
effects,
primarily
driven
Ag+
ion
release
disruption
function.
However,
it
is
more
likely
organic
content,
rather
than
size,
influenced
anticancer
activity,
commercial
Ag
NPs,
despite
smaller
crystallite
sizes,
exhibit
less
effective
activity.
ZnO
P
showed
increased
oxygen
(ROS)
generation,
correlated
higher
cytotoxicity,
while
A
produced
lower
ROS
levels,
resulting
in
diminished
effects.
comparative
analysis
revealed
differences
LD50
values
toxicity
profiles.
Differentiated
cells
resistance
to
ZnO,
AgNPs
Ag/Ag2O-based
materials
had
similar
both
types.
This
study
emphasizes
crucial
role
bioactive
compounds
C.
vulgaris
modulating
nanoparticle
surface
chemistry,
cytotoxicity.
results
provide
valuable
insights
designing
safer
biomedical
applications,
especially
targeting
tumor-like
exploring
relationships
between
polarity,
capping
agents,
nanocomposite
structures.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(20), P. 15539 - 15549
Published: Jan. 1, 2025
CS/Zn
NPs
were
formed
by
chelating
CS
with
Zn
2+
in
the
fresh
zinc
electrochemical
solution.
NP-based
CMC
coating
reduced
strawberry
spoilage
and
maintained
fruit
quality,
indicating
its
potential
application
preservation.
Journal of Applied Toxicology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 31, 2024
ABSTRACT
Zinc
oxide
nanoparticles
(ZnO
NPs)
are
widely
used
in
manufacturing
cosmetic
and
pharmaceutical
products.
Although
previous
studies
have
reported
their
toxic
effects
on
fish,
the
underlying
mechanisms
behind
yet
to
be
identified.
This
study
evaluated
impact
of
ZnO
NPs
marine
medaka's
survival,
heart
rates
(
Oryzias
melastigma
),
expression
genes
linked
neurotoxicity
cardiovascular
toxicity.
Marine
medaka
samples
were
exposed
at
varying
concentrations:
0.01,
0.1,
1,
10
mg/L.
Survival
monitored
12th
day
postfertilization.
Gene
related
α‐tubulin
,
elavl3
gap43
gfap
)
toxicity
cdh2
atp2a1
cacna1da
crhr1
ahrra
arnt2
was
assessed
by
performing
real‐time
polymerase
chain
reaction.
The
survival
rate
not
significantly
impacted
exposure
up
1
mg/L
NPs;
however,
resulted
a
60%
reduction
rate.
did
change
across
all
concentrations.
High
NP
concentrations
(10
mg/L)
suppressed
neurotoxic
cardiotoxic
genes,
including
.
exhibited
dose‐dependent
affecting
neurological
functions.
These
findings
underscore
potential
risks
aquatic
organisms.
distinct
actions
dissolved
ions
complicate
interpretation
results,
as
this
measure
ion
release,
critical
factor
understanding
Moreover,
may
cause
oxidative
stress
disrupt
cellular
pathways.
Furthermore,
without
distinguishing
between
effects,
it
is
challenging
determine
exact
highlight
need
for
future
particles
separately
clarify
contributions
toxicity,
where
action
still
debated.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 27 - 64
Published: Oct. 11, 2024
Nanomaterials
possess
different
properties
that
make
them
suitable
for
application
in
numerous
fields.
Nonetheless,
their
toxicity,
especially
neurotoxic
propensity,
is
a
considerable
area
of
investigation.
In
this
chapter,
nanomaterial
neurotoxicity
reviewed
detail,
with
an
emphasis
on
assessing
levels
exposure
or
routes
entry
to
brain
cells,
mechanisms
by
which
they
cause
damage,
and
specific
types
damage.
addition,
vitro,
ex
vivo,
vivo
models
used
measure
are
described.
This
chapter
provides
discussion
matter
considering
challenges
terms
characterization,
risk
assessment,
regulatory
aspects.
concludes
underscoring
the
importance
toxicological
prediction
safe-by-design
solutions.
Future
research
should
address
long-term
effects
using
nanomaterials
means
preventing
neurotoxicity.
