Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 421 - 421
Published: March 31, 2025
Aging is a multifactorial process influenced by genetic predisposition and lifestyle choices. Environmental exposures are too often overlooked. pollutants—ranging from airborne particulate matter heavy metals to endocrine disruptors microplastics—accelerate biological aging. Oxidative stress major molecular initiating event, driving inflammation toxicity across levels. We detail the mechanisms which pollutants enhance reactive oxygen species (ROS) production. This oxidative inflicts damage on DNA, proteins, lipids, accelerating telomere shortening, dysregulating autophagy, ultimately epigenetic age acceleration. For instance, exposure polycyclic aromatic hydrocarbons, benzene, pesticides has been associated with increased DNA methylation age. Early-life factors such as tobacco alcohol consumption further contribute accelerated The cumulative loss of healthy life years caused these can conceivably reach between 5 10 per person. Addressing pollutant-induced aging through regulatory measures, changes, therapeutic interventions essential mitigate their detrimental impacts, extending healthspan improving quality in populations.
Language: Английский