Ni-catalyzed ligand-controlled divergent and selective synthesis

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(11), P. 2951 - 2976

Published: May 5, 2023

Language: Английский

---

Iron-catalysed alkenylzincation of allenes via electrophilicity reversal

Nature Catalysis, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

---

Copper-Catalyzed C–B(sp³) Bond Formation through the Intermediacy of Cu–B(sp³) Complex

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

The vast majority of transition metal (TM) catalyzed borylative transformations rely on TM-B(sp2) complexes. Contrastingly, the chemistry TM-B(sp3) species and their potential in catalytic borylation remain surprisingly underdeveloped, due probably to lack suitable boron(sp3) reagents. Herein, we employ our recently developed sp2-sp3 diboron reagent successfully enable a copper-catalyzed hydroboration allenes for C-B(sp3) bond formation. A comprehensive mechanistic study, including isolation structural characterization Cu-B(sp3) complex, substantiates presence intermediate cycle.

Language: Английский

---

Selective Hydrosilylation and Hydroboration of Allenes Catalyzed by Cobalt‐Pincer Complexes

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(12), P. 2775 - 2783

Published: April 24, 2024

Abstract Achieving precise control over regioselectivity and stereoselectivity in the hydroelementation of terminal allenes presents a formidable challenge. Despite existence various catalytic methods for their functionalization, this entire class reactions remains significantly underdeveloped demands extensive research. Here, we report method using inexpensive PN 5 P pincer cobalt complexes built on triazine backbone. Depending substituent at ring, enables selective synthesis E‐alkenylsilane or Z‐allylborane derivatives. In presented approach, silanes pinacoloboranes play dualistic role simultaneous activator substrate excluding need addition external bases. Finally, application potential obtained compounds was demonstrated by performing further functionalizations compounds.

Language: Английский

---

Asymmetric dihydroboration of allenes enabled by ligand relay catalysis

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 18, 2024

Language: Английский

---

Ligand-controlled regiodivergent Ni-catalyzed trans-hydroboration/carboboration of internal alkynes with B₂pin₂

Chemical Science, Journal Year: 2024, Volume and Issue: 15(6), P. 2236 - 2242

Published: Jan. 1, 2024

With the aid of directing group strategy, an approach for synthesis alkenyl and 1-naphthyl boronates with stereo- regioselectivity via ligand-controlled Ni-catalyzed trans -hydroboration/carboboration internal alkynes was developed.

Language: Английский

---

Cation-Assisted Hydrosilylation of Alkynes Catalyzed by a Low-Valent Iron Complex Bearing Noninnocent Ligands

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(16), P. 12163 - 12172

Published: July 30, 2024

The field of iron catalysis often faces hurdles in accommodating its transient and unstable low-valent intermediates. By harnessing the noninnocent character commercial bathocuproine ligand, we managed to develop a reliable functionalization alkynes with primary, secondary, tertiary silanes but also germanium hydrides, catalyzed by complex. robustness catalyst enabled gram-scale synthesis vinylsilanes, low catalytic loading, one-pot, hetero, bis-hydrosilylation, high steric build-up. Mechanistic studies suggest an important effect MgII cation resulting from reduction precatalyst, assisting dynamic generation highly reactive, under-coordinated species stable

Language: Английский

---

Transition metal-catalyzed selective hydroboration of allenes

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

---

Copper‐Catalyzed Regio‐ and Enantioselective Hydroboration of Difluoroalkyl‐Substituted Internal Alkenes

Advanced Science, Journal Year: 2023, Volume and Issue: 10(35)

Published: Oct. 25, 2023

Abstract Catalytic asymmetric hydroboration of fluoroalkyl‐substituted alkenes is a straightforward approach to access chiral small molecules possessing both fluorine and boron atoms. However, enantioselective without elimination has been long‐standing challenge in this field. Herein, copper‐catalyzed difluoroalkyl‐substituted internal with high levels regio‐ enantioselectivities reported. The native carbonyl directing group, copper hydride system, bisphosphine ligand play crucial roles suppressing the undesired fluoride elimination. This atom‐economic protocol provides practical synthetic platform obtain wide scope enantioenriched secondary boronates bearing difluoromethylene moieties under mild conditions. Synthetic applications including functionalization biorelevant molecules, versatile functional group interconversions, preparation difluoroalkylated Terfenadine derivative are also demonstrated.

Language: Английский

---

Stereodivergent atom transfer radical addition of α-functionalized alkyl iodides to alkynes: a strategy for selective synthesis of both E- and Z-iodoalkenes

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(90), P. 13251 - 13254

Published: Jan. 1, 2024

A photo-redox stereodivergent atom transfer radical addition of α-functionalized alkyl iodides to alkynes allows the selective and efficient synthesis both E - Z -iodoalkenes.

Language: Английский

---