Association of interleukin-6, ferritin, and lactate dehydrogenase with venous thromboembolism in COVID-19: a systematic review and meta-analysis

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 16, 2024

Abstract Background Coronavirus disease 2019 (COVID-19) is frequntly accompanied by venous thromboembolism (VTE), and its mechanism may be related to the abnormal inflammation immune status of COVID-19 patients. It has been proved that interleukin-6 (IL-6), ferritin lactate dehydrogenase (LDH) play an important role in occurrence VTE infection. But whether they can server as predictors for still unclear. In this study, we performed a systematic review meta-analysis compare IL-6, LDH non-VTE patients order shed light on prevention treatment VTE. Methods Related literatures were searched PubMed, Embase, Web Science, Google Scholar, China National Knowledge Infrastructure (CNKI), WANGFANG. divided into group group. Meta-analysis was then conducted levels between two groups. Results We finally included analyzed 17 from January October 2022. There total 7,035 patients, with weighted mean age 60.01 years. Males accounted 62.64% 61.34% intensive care unit (ICU). Weighted difference (WMD) 31.15 (95% CI: 9.82, 52.49), 257.02 51.70, 462.33) 41.79 -19.38, 102.96), respectively. The above results indicated than compared group, had significantly higher IL-6 but similar LDH. Conclusion This pointed out elevated possitive associated VTE, thus could used biological predictive indicators among However, no association found level Therefore, close monitoring changes concentrations great value assisting clinicans rapidly identify thrombotic complications hence facilitating timely effective managment. Further studies are required terms clinical cytokines infection, more reliable controls interventional trials.

Language: Английский

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Pulmonary Embolism in Post-CoviD-19 Patients, a Literature Review: Red Flag for Increased Awareness?

SN Comprehensive Clinical Medicine, Journal Year: 2022, Volume and Issue: 4(1)

Published: Aug. 19, 2022

Language: Английский

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Sialylated Glycan Bindings from SARS-CoV-2 Spike Protein to Blood and Endothelial Cells Govern the Severe Morbidities of COVID-19

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 17039 - 17039

Published: Dec. 1, 2023

Consistent with well-established biochemical properties of coronaviruses, sialylated glycan attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus’s pathology. SP attaches aggregates red blood (RBCs), as shown in many pre-clinical clinical studies, causing pulmonary extrapulmonary microthrombi hypoxia severe COVID-19 patients. heavily surfaces platelets (which, like RBCs, have no ACE2) endothelial (having minimal compound this vascular damage. Notably, experimentally induced RBC aggregation vivo causes same morbidities for COVID-19, including microvascular occlusion, clots, myocarditis. Key risk factors morbidity, older age, diabetes obesity, all characterized by markedly increased propensity clumping. For mammalian species, degree susceptibility correlates aggregability p = 0.033. five human betacoronaviruses, two common cold strains express an enzyme that releases attachments, while deadly SARS, MERS do not, although viral loads infections similar. These insights also explain previously puzzling efficacy certain generics against may support development future therapeutic strategies long COVID

Language: Английский

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Efficacy and Safety of Tinzaparin in Prophylactic, Intermediate and Therapeutic Doses in Non-Critically Ill Patients Hospitalized with COVID-19: The PROTHROMCOVID Randomized Controlled Trial

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(19), P. 5632 - 5632

Published: Sept. 24, 2022

Hospitalized patients with COVID-19 are at increased risk of thrombosis, acute respiratory distress syndrome and death. The optimal dosage thromboprophylaxis is unknown. aim was to evaluate the efficacy safety tinzaparin in prophylactic, intermediate, therapeutic doses non-critical admitted for pneumonia. PROTHROMCOVID a randomized, unblinded, controlled, multicenter trial enrolling non-critical, hospitalized adult Patients were randomized prophylactic (4500 IU), intermediate (100 IU/kg), or (175 IU/kg) groups. All administered once daily during hospitalization, followed by 7 days discharge. primary outcome composite endpoint symptomatic systemic thrombotic events, need invasive non-invasive mechanical ventilation, death within 30 days. main major bleeding Of 311 subjects 300 included prespecified interim analysis (mean [SD] age, 56.7 [14.6] years; males, 182 [60.7%]). from randomization occurred 58 (19.3%) total population; 19 (17.1 %) group, 20 (22.1%) (18.5%) dose group (

Language: Английский

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SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

COVID-19 associated coagulation abnormalities and thrombosis are life-threatening complications after SARS-CoV-2 infection. However, the underlying mechanisms unclear. Here, we found that spike (S) protein induced excessive reactive oxygen species (ROS) production, disrupting mitochondrial dynamics causing endothelial cells damage, thereby promoting thrombogenesis. Mechanistically, S inhibited expression of signaling lymphocytic activation molecule family 8 (SLAMF8) to induce an upregulation NADPH oxidase 2 (NOX2) p66SHC phosphorylation. This NOX2-p66SHC axis resulted in a persistent elevation ROS disorder, ultimately leading injury. infection also promoted transformation into prothrombotic phenotype by inhibiting SLAMF8. Furthermore, single-cell sequencing analysis revealed negative correlation between SLAMF8 thrombotic activity patients. Notably, overexpression reversed protein-mediated increase blood flow obstruction platelet aggregation observed mice with ferric chloride-induced thrombosis. These findings suggest distinct mechanism pathogenesis SARS-CoV-2-associated thrombosis, providing novel perspectives strategies for prevention, management treatment individuals or long COVID.

Language: Английский

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