Early Childhood Family Threat and Longitudinal Amygdala-Mpfc Circuit Development: Examining Cortical Thickness and Gray Matter-White Matter Contrast
Published: Jan. 1, 2024
Early
threat-associated
cortical
thinning
may
be
interpreted
as
accelerated
development.
However,
non-adaptive
processes
show
similar
macrostructural
changes.
Examining
thickness
(CT)
together
with
grey/white-matter
contrast
(GWC),
a
proxy
for
intracortical
myelination,
enhance
the
interpretation
of
CT
findings.
In
this
prospective
study,
we
examined
associations
between
early
life
family-related
threat
(harsh
parenting,
family
conflict,
and
neighborhood
safety)
GWC
development
from
late
childhood
to
middle
adolescence.MRI
was
acquired
4200
children
(2069
boys)
Generation
R
study
at
ages
8,
10
14
years
(in
total
6114
scans),
whom
1697
had
>1
scans.
Linear
mixed
effect
models
were
used
examine
factor-by-age
interactions
on
amygdala
volume,
caudal
rostral
anterior
cingulate
(ACC)
medial
orbitofrontal
cortex
(mOFC)
GWC.A
safety-by-age-interaction
found
ACC
GWC,
suggesting
less
developmental
change
in
unsafe
neighborhoods.
Moreover,
after
more
stringent
correction
motion,
conflict
associated
greater
but
GWC.
Results
suggest
that
blunt
Our
results,
therefore,
do
not
provide
evidence
structural
amygdala-mPFC
circuit
8-14
years.
Language: Английский
Early childhood family threat and longitudinal amygdala-mPFC circuit development: Examining cortical thickness and gray matter-white matter contrast
Developmental Cognitive Neuroscience,
Journal Year:
2024,
Volume and Issue:
70, P. 101462 - 101462
Published: Oct. 16, 2024
Language: Английский