Phytochemical constituents, antioxidant and antibacterial activities of Plectocephalus varians (A. Rich) C. Jeffrey ex Cufod root extracts DOI Creative Commons

Melaku Birhane Gashaye,

Yihenew Simegniew Birhan

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 30, 2023

Abstract Plants have been used to treat diverse types of diseases in different cultural groups around the globe. In this regard, root Plectocephalus varians (P. varians) is claimed a beneficiary effect treating cancer and hemorrhoids Ethiopia. Hence, study aimed at phytochemical investigation, antioxidant, antibacterial activities n-hexane, acetone, methanolic extracts P. root. The crude were obtained through maceration technique. total phenolic content (TPC) flavonoid contents (TFC) estimated using Folin-Ciocalteu Reagent (FCR) aluminum chloride colorimetric assays, respectively. antioxidant determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ferric reducing power (FRAP) assays. assessed disc diffusion method. results echoed presence alkaloids, saponins, flavonoids, steroids, phenols, tannins, anthraquinones, terpenoids, polyphenols, glycosides varians. extract (MRE) had highest TPC (107.18 mgGAE/g) TFC (120.194 mgQE/g) followed acetone (ARE) (TPC = 98.68 mgGAE/g; 64.038 n-hexane (HRE) 12.39 9.917 mgQE/g). DPPH FRAP assays demonstrated effects HRE (IC50 681.75 ppm; EC50 60.65 ppm), ARE 165.73 51.67 ppm) MRE 132.06 30.97 Furthermore, fractions elicited pronounced dose-dependent growth inhibition against Staphylococcus aureus, Streptococci pyogenes, Escherichia coli, Klebsiella pneumoniae with mean zone (MZI) ranging from 11 ± 0.38 20 0.04 mm 800 ppm. Overall, present provides ethnopharmacological evidence suggesting medicinal importance also call for further bioassay-guided screening vitro and/or vivo bioactivity testing.

Language: Английский

Unlocking the Folkloric Uses of Rhus retinorrhoea Steud. Ex A. Rich Leaf Crude Extracts: Phytochemical Screening, Antioxidant and Antibacterial Activities DOI Creative Commons
Yihenew Simegniew Birhan,

Ayenew Getachew Binalf,

Biniyam Zewdie Hiruy

et al.

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101674 - 101674

Published: Jan. 1, 2025

Language: Английский

Citations

1
Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry DOI Creative Commons
Yihenew Simegniew Birhan

Chinese Medicine, Journal Year: 2022, Volume and Issue: 17(1)

Published: Nov. 19, 2022

Abstract Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people worldwide. Patients with status epilepticus (SE) suffer from devastating comorbidities and high incidence of mortalities. Antiepileptic drugs (AEDs) are the mainstream treatment options for symptomatic relief epilepsy. The refractory epilepsy dose-dependent neurotoxicity AEDs such as fatigue, cognitive impairment, dizziness, attention-deficit behavior, other side effects major bottlenecks in treatment. In low- middle-income countries (LMICs), patients failed to adhere regimens consider complementary alternative medicines (CAMs) relieve pain due (SE). Plant-based CAMs widely employed across globe including Ethiopia. current review documented around 96 plant species (PS) often used It also described vivo anticonvulsant activities toxicity profiles antiepileptic medicinal plants (MPs). Moreover, phytochemical constituents MPs profound were assessed. result reiterated lot has be done show association between herbal-based pharmacological regarding their mechanism action (MOA), profiles, bioactive so they can advance into clinics serve option

Language: Английский

Citations

25
Precision nutrition-based strategy for management of human diseases and healthy aging: current progress and challenges forward DOI Creative Commons
Vipin Singh,

Xiao-Hu Hu,

Amit Kishore Singh

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 9, 2024

Currently, the treatment of various human ailments is based on different therapeutic approaches including traditional and modern medicine systems. Precision nutrition has come into existence as an emerging approach considering diverse aspects such age, sex, genetic epigenetic makeup, apart from pathophysiological conditions. The continuously gradually evolving disciplines genomics about have elucidated importance variations, information, expression myriads genes in disease progression involvement modulating responses. Further, investigations presented considerable role gut microbiota comprising commensal symbionts performing innumerable activities release bioactive molecules, defense against pathogenic microbes, regulation immunity. Noteworthy, characteristics microbiome change depending host attributes, environmental factors, habitat, addition to diet, therefore can be employed a biomarker unravel response given food. specific diet components thereof suggested for supporting enrichment desired microbial community some extent important part precision achieve not only goal health but also healthy aging.

Language: Английский

Citations

4
Phytochemical constituents, antioxidant and antibacterial activities of Plectocephalus varians (A. Rich.) C. Jeffrey ex Cufod root extracts DOI Creative Commons

Melaku Birhane Gashaye,

Yihenew Simegniew Birhan

BMC Complementary Medicine and Therapies, Journal Year: 2023, Volume and Issue: 23(1)

Published: April 28, 2023

Abstract Plants have been used to treat diverse types of diseases in different cultural groups around the globe. In this regard, root Plectocephalus varians ( P. ) is claimed a beneficiary effect treating cancer and hemorrhoids Ethiopia. Hence, study aimed at phytochemical investigation, antioxidant, antibacterial activities n-hexane, acetone, methanolic extracts root. The crude were obtained through maceration technique. total phenolic content (TPC) flavonoid contents (TFC) estimated using Folin-Ciocalteu Reagent (FCR) aluminum chloride colorimetric assays, respectively. antioxidant determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ferric reducing power (FRAP) assays. assessed disc diffusion method. results echoed presence alkaloids, saponins, flavonoids, steroids, phenols, tannins, anthraquinones, terpenoids, polyphenols, glycosides . extract (MRE) had highest TPC (107.18 mg GAE/g) TFC (120.194 QE/g) followed acetone (ARE) (TPC = 98.68 GAE/g; 64.038 n-hexane (HRE) 12.39 9.917 QE/g). DPPH FRAP assays demonstrated effects HRE (IC 50 681.75 ppm; EC 60.65 ppm), ARE 165.73 51.67 ppm) MRE 132.06 30.97 Furthermore, fractions elicited pronounced dose-dependent growth inhibition against Staphylococcus aureus , Streptococci pyogenes Escherichia coli Klebsiella pneumoniae with mean zone (MZI) ranging from 11 ± 0.38 20 0.04 mm 800 ppm. Overall, present provides ethnopharmacological evidence suggesting medicinal importance also call for further bioassay-guided screening vitro and/or vivo bioactivity testing.

Language: Английский

Citations

7
Appraisal of phytochemical constituents, antioxidant and antibacterial activities of folkloric Pentanema confertiflorum rootbark extracts DOI
Yihenew Simegniew Birhan,

Wale Aderaw Bishaw,

Nakachew Minuye Mengesha

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 44(1), P. 15 - 22

Published: May 22, 2023

Medicinal plants have cultural prominence in the management of ailments worldwide. The different organs Pentanema confertiflorum (hereafter referred as P. confertiflorum) been used to ameliorate diseases Ethiopia. Thus, this study focused on qualitative and quantitative phytochemical analysis, antioxidant, antibacterial screening rootbark solvent fractions. was successively soaked with petroleum ether, chloroform, methanol. total phenolic (TPC), flavonoid (TFC), alkaloid contents (TAC) crude extracts were determined through Folin-Ciocalteu Reagent (FCR), aluminum chloride colorimetric, bromocresol green (BCG) assays, respectively. In addition, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ferric-reducing antioxidant power (FRAP) assays employed determine activity extracts. Moreover, antimicrobial assessed against bacteria strains via disc diffusion method. investigation resonated abundance several secondary metabolites, especially methanolic extract (MRBE). MRBE had highest TPC (76.7 mg GAE/g extracts), TFC (86.89 QE/g TAC (80.68 ATE/g extracts) compared ether chloroform Consistent its TPC, TFC, TAC, demonstrated better DPPH (IC50 = 44.53 ppm) FRAP (EC50 42.72 ppm). all induced dose-dependent Streptococci pyogenes Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli. preliminary findings suggested presence a strong correlation between folkloric use observed activity. Rigorous studies such isolation characterization bioactive compounds, detailed bioactivity toxicity are desirable bring about safe effective lead compounds.

Language: Английский

Citations

4
Zootherapeutic Uses of Animals and Their Parts: An Important Element of the Traditional Knowledge of the Safi Province, Morocco DOI Creative Commons
Ahmed Lemhadri, Taoufiq Benali, Wondimagegnehu Tekalign

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(22), P. e40435 - e40435

Published: Nov. 1, 2024

The Moroccan population harbors rich traditional knowledge used to treat various human diseases. This is the first study aimed at exploring ethnozoological practices in Morocco.

Language: Английский

Citations

1
Phytochemical constituents, antioxidant and antibacterial activities of Plectocephalus varians (A. Rich) C. Jeffrey ex Cufod root extracts DOI Creative Commons

Melaku Birhane Gashaye,

Yihenew Simegniew Birhan

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 30, 2023

Abstract Plants have been used to treat diverse types of diseases in different cultural groups around the globe. In this regard, root Plectocephalus varians (P. varians) is claimed a beneficiary effect treating cancer and hemorrhoids Ethiopia. Hence, study aimed at phytochemical investigation, antioxidant, antibacterial activities n-hexane, acetone, methanolic extracts P. root. The crude were obtained through maceration technique. total phenolic content (TPC) flavonoid contents (TFC) estimated using Folin-Ciocalteu Reagent (FCR) aluminum chloride colorimetric assays, respectively. antioxidant determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ferric reducing power (FRAP) assays. assessed disc diffusion method. results echoed presence alkaloids, saponins, flavonoids, steroids, phenols, tannins, anthraquinones, terpenoids, polyphenols, glycosides varians. extract (MRE) had highest TPC (107.18 mgGAE/g) TFC (120.194 mgQE/g) followed acetone (ARE) (TPC = 98.68 mgGAE/g; 64.038 n-hexane (HRE) 12.39 9.917 mgQE/g). DPPH FRAP assays demonstrated effects HRE (IC50 681.75 ppm; EC50 60.65 ppm), ARE 165.73 51.67 ppm) MRE 132.06 30.97 Furthermore, fractions elicited pronounced dose-dependent growth inhibition against Staphylococcus aureus, Streptococci pyogenes, Escherichia coli, Klebsiella pneumoniae with mean zone (MZI) ranging from 11 ± 0.38 20 0.04 mm 800 ppm. Overall, present provides ethnopharmacological evidence suggesting medicinal importance also call for further bioassay-guided screening vitro and/or vivo bioactivity testing.

Language: Английский

Citations

0