Expert Review of Respiratory Medicine, Journal Year: 2024, Volume and Issue: 18(3-4), P. 111 - 125
Published: April 2, 2024
Introduction This review summarizes our current understanding of the respiratory microbiome in COPD and Bronchiectasis. We explore interplay between microbial communities, host immune responses, disease pathology treatment outcomes.
Language: Английский
American Journal of Respiratory and Critical Care Medicine, Journal Year: 2024, Volume and Issue: 210(11), P. 1300 - 1307
Published: Oct. 15, 2024
Language: Английский
Citations
3
Computational and Structural Biotechnology Journal, Journal Year: 2023, Volume and Issue: 21, P. 4933 - 4943
Published: Jan. 1, 2023
The study of the respiratory microbiome has entered a multi-omic era. Through integrating different omic data types such as metagenome, metatranscriptome, metaproteome, metabolome, culturome and radiome surveyed from specimens, holistic insights can be gained on lung its interaction with host immunity inflammation in diseases. power multi-omics have moved field forward associative assessment alterations to causative understanding pathogenesis chronic, acute other However, application remains unique challenges sample processing, integration, downstream validation. In this review, we first introduce applicable studying microbiome. We next describe approaches for focusing dimensionality reduction, association prediction. then summarize progresses finally discuss current share our thoughts future promises field.
Language: Английский
Citations
7
American Journal of Respiratory and Critical Care Medicine, Journal Year: 2024, Volume and Issue: 210(3), P. 252 - 253
Published: March 26, 2024
"Of Mucus and Microbes: The Sticky Issue of Mucin-Microbiome Interactions in COPD ." American Journal Respiratory Critical Care Medicine, 0(ja), pp.
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e30322 - e30322
Published: May 1, 2024
•Aromatic Plants Environmental Health Engineering (APEHE), a new research direction.•Aerosols reverse bacterial resistance by inducing mutations in sdhA, scrA, and PEP.•Binding to AKT1, MMP9, TLR4 could affect human health.•Acetaminophen flurbiprofen occur naturally the air.•Potential benefit climate, energy, economics other areas. It is important note that every ecological niche an ecosystem significant. This study aims assess importance of medicinal aromatic plants (MAPs) from multiple perspectives. A primary model Aromatic (APEHE) has been designed constructed. The APEHE system was used collect aerosol compounds, it experimentally verified these compounds have potential impact health binding AKT1 as target, MMP9 secondary targets. These may indirectly immunity reversing drug drug-resistant bacteria nasal cavity. mainly achieved through combined PEP. Our findings are based on Network pharmacology molecular binding, drug-resistance rescue experiments, well transcriptomics metabolomics experiments. suggested direct or indirect effects health.We demonstrate APEHE's numerous benefits, such attenuation elimination airborne microorganisms environment, enhancing carbon nitrogen storage terrestrial ecosystems, promoting formation low-level clouds strengthening virtuous cycle Earth's ecosystems. also supports development transdisciplinary technologies, including terpene energy production. facilitates creation sustainable circular economy provides additional economic advantages urban optimisation, fresh insights into areas habitability planets. serve leverage point for Earth system. We created direction. health. all know earth whole system, we disadvantages environmental damage air pollution, excessive warming earth. In very nodes, addition metabolites, produce metabolites (SM) play various roles response changing growth [1Kroymann J. Natural diversity adaptation plant metabolism.Current Opin Plant Biol. 2011; 14: 246-251https://doi.org/10.1016/j.pbi.2011.03.021Crossref Scopus (162) Google Scholar, 2Berini J.L. Brockman S.A. Hegeman A.D. Reich P.B. Muthukrishnan R. Montgomery R.A. Forester J.D. Combinations abiotic factors differentially alter production five woody species boreal-temperate transition zone.Front Sci. 2018; 9: 1257https://doi.org/10.3389/fpls.2018.01257Crossref (70) Scholar]. Historical records show ancient times, were frequently combat epidemics, plague. China, thousands years, traditional Chinese medicine "aromatic avoid filth, removal turbid evils" concept. However, due limitation scientific research, agricultural technology living, afforestation structure City , natural environment not enough attention. Their benefits only considered relation body sickness.Research shown volatile fat-soluble small molecule can cross blood-brain barrier therapeutic effect reducing inflammation antioxidants [3Shikha Srivastava, Saurabh Manju Rawat Singh, Deependra Babu L. Tekwani, Chapter 11 - Novel perspectives delivery bioactives blood–brain treatment brain diseases, Editor(s): Jagat R.Kanwar, Nagendra Singh Chauhan,Advances Avenues Development Carriers Bioactives Biological Agents,Academic Press,2020,Pages 317-341, ISBN 9780128196663, https://doi.org/10.1016/B978-0-12-819666-3.00011-0.Google 4Menizibeya O. Welcome,Blood role phytochemicals.PharmaNutrition. 2020; (ISSN 2213-4344)100177https://doi.org/10.1016/j.phanu.2020.100177Crossref (17) 5Ahmed Walaa M.S. Abdel-Azeem Naglaa M. Ibrahim Marwa A. Helmy Nermeen Radi Abeer Neuromodulatory cinnamon oil behavioural disturbance, CYP1A1, iNOStranscripts neurochemical alterations induced deltamethrin rat brain.Ecotoxicology Safety. 2021; 209 0147-6513)111820https://doi.org/10.1016/j.ecoenv.2020.111820Crossref (21) possible pathway olfactory epithelium central nervous (CNS) bulb respiratory sedative stimulator absorb molecules blood circulation [5Ahmed decocting process medicine, easily air, if decoction, many effective volatiles will be lost. Traditional different methods processing use materials. During epidemic period, burning cooking hinder spread disease. Although past prevention infectious diseases cannot understand what outbreaks, but culture 24 solar terms discretionary MAPs. Dragon Boat Festival, common hang wormwood calamus doors, make wear MAPs like sachets. practices basis our analysis correlation between health, their significance ecosystem.It hypothesized significant ecosystems interacting with organisms surroundings affecting within environment. To verify this hypothesis, designed, relevant experiments conducted. For centuries, humans plant-produced organic pharmaceuticals herbal medicines treating antiviral activity against SARS-cov[6Wen C.C. Kuo Y.H. Jan J.T. et al.Specific terpenoids lignoids possess potent activities severe acute syndrome coronavirus.J Med Chem. 2007; 50: 4087-4095https://doi.org/10.1021/jm070295sCrossref PubMed (475) Approximately 25% drugs originate [7De Luca V. Salim Atsumi S.M. Yu F. Mining biodiversity plants: revolution making.Science. 2012; 336: 1658-1661https://doi.org/10.1126/science.1217410Crossref (263) 8Wurtzel E.T. Kutchan T.M. metabolism, diverse chemistry set future.Science. 2016; 353: 1232-1236https://doi.org/10.1126/science.aad2062Crossref (160) Scholar], acquisition symbiotic relationship[9Cordell G.A. Biodiversity discovery — relationship.Phytochemistry. 2000; 55: 463-480https://doi.org/10.1016/s0031-9422(00)00230-2Crossref plants, SM classified three categories: terpenes, phenolic alkaloids, (VOCs). variety evidence shows VOCs external interaction[10Lin Tiantian Vrieling Klaas Laplanche Diane Klinkhamer Peter G.L. Lou Yonggen Bekooy Leon Degen Thomas Bustos-Segura Carlos Turlings Ted C.J. Desurmont Gaylord Evolutionary changes invasive support defensive volatiles.Current Biology. 31 (e5,ISSN 0960-9822): 3450-3456https://doi.org/10.1016/j.cub.2021.05.055Abstract Full Text PDF (18) which largest group [11Mani Park S. Kim J.A. Lee S.I. K. Metabolic Perturbation Synthetic Biology Strategies Terpenoid Production-An Updated Overview.Plants (Basel). 2021 Oct 14; 10 (PMID: 34685985; PMCID: PMC8539415): 2179https://doi.org/10.3390/plants10102179Crossref (9) Terpenes biological functions, antibacterial, anti-worming, pathogen attack [12González Mera I.F. al.Secondary main classes, phytochemical pharmacological activities.Bionatura. 2019; 4: 1000-1009https://doi.org/10.21931/RB/2019.04.04.11Crossref (30) 13Gershenzon Dudareva N. function products world.Nat Chem 3: 408-414Crossref (1448) evolved defense mechanisms viral, fungal infections, stem complex interactions biochemical, genetic, cellular factors[14Musidlak Nawrot Goździcka-Józefiak Which Proteins Are Involved Antiviral Defense?Review Vivo Vitro Activities Selected Viruses.International journal sciences. 2017; 18: 2300https://doi.org/10.3390/ijms18112300Crossref (53) Essential Oil (EO) (also known oil) liquid extracted parts (flowers, buds, seeds, leaves, branches, bark, herbs, wood, fruit roots) [15Prabuseenivasan Jayakumar Ignacimuthu vitro antibacterial some essential oils.BMC Complement Altern Med. 2006; 6: 1-8Crossref (724) antifungal, antiviral, antioxidant, insecticidal properties. Furthermore, demonstrated microbes plaque[16Elaissi Rouis Z. Salem N.A.B. al.Chemical composition 8 eucalyptus species' oils evaluation antifungal activities.BMC 12: 81https://doi.org/10.1186/1472-6882-12-81Crossref (161) 17Schnitzler P. al.Susceptibility clinical herpes simplex virus type 1 strains ginger, thyme, hyssop, sandalwood.Antimicrob Agents Chemother. 51: 1859-1862Crossref (145) 18Naveed Hussain I. Tawab al.Antimicrobial bioactive components Pakistani spices Salmonella multi-drug resistant bacteria.BMC 2013; 13: 265https://doi.org/10.1186/1472-6882-13-265Crossref (104) Such HSV-1 [19Lai W.L. Chuang H.S. M.H. Wei C.L. Lin C.F. Tsai Y.C. Inhibition thymol-related monoterpenoids.Planta Medica. 78: 1636-1638Crossref (57) HSV-2 [20Schnitzler Schön Reichling Australian tea tree cell culture.Pharmazie. 2001; 56: 343-347PubMed 21Schuhmacher Schnitzler Virucidal peppermint enveloped viruses 2 vitro.Phytomedicine. 2003; 10: 504-510Abstract (0) 22Reichling Koch C. Stahl-Biskup E. Sojka beta-triketone-rich Leptospermum scoparium (manuka culture.Planta. 2005; Med71: 1123-1127Google [17Schnitzler Bovine herpesvirus-1 [23Boubaker–Elandalousi al.Non-cytotoxic Thymus capitata extracts prevent infection cultures.BMC Veterinary Research. 2014; 231Crossref (12) HIV-1 [24Mediouni al.Oregano its principal component carvacrol inhibit fusion target cells.Journal Virology. JVI (00147-00120)Google SARS-COV [25Loizzo Saab Tundis Statti G. Menichini Lampronti Gambari Cinatl Doerr H. Phytochemical Analysis Oils Seven Lebanon Species.Chemistry & Biodiversity. 2008; 5: 461-470https://doi.org/10.1002/cbdv.200890045Crossref (214) summary, containing primarily reduce inactivate microbial vivo administration routes:①.In interference viral particles and/or envelope mask structures receptors required adsorption entry host cells, attenuate activity, act before bind body.②.In vivo, multistage body, competitive contact surface specific proteases adsorption, blocking membrane, regulation immune anti-inflammatory, infections body. 19Lai 20Schnitzler 23Boubaker–Elandalousi 24Mediouni 26Siddiqui Y.M. Ettayebi Haddad A.M. Al-Ahdal M.N. Effect viruses: oregano clove Newcastle disease virus.Med.Sci.Res. 1996; 24: 185-186Google 27Huang X. Gao Y. Xu al.Molecular mechanism underlying anti-inflammatory Ligularia fischeri (Ledeb) Turcz network pharmacology.BMC Ther. 20: 109https://doi.org/10.1186/s12906-020-2855-3Crossref (4) 28Tariq Tariq Wani Rasool W. Shafi Bhat M.A. Prabhakar Shalla A.H. Rather comprehensive review chemical constituents pathogens.Microb Pathog. 2019 Sep; 134 (Epub Jun 11. PMID: 31195112)103580https://doi.org/10.1016/j.micpath.2019.103580Crossref (408) 29Borges Raphaelle Sousa Ortiz Brenda Lorena Sánchez Pereira Arlindo César Matias Keita Hady Carvalho José Tavares Rosmarinus officinalis oil: phytochemistry, action involved.Journal Ethnopharmacology. 229 0378-8741): 29-45https://doi.org/10.1016/j.jep.2018.09.038Crossref (193) 30Horváth Ács tract highlighting action: review.Flavour Fragr.J. 2015; 30: 331-341https://doi.org/10.1002/ffj.3252Crossref (84) Scholar] Some clove, peppermint, citronella strongest vapor systems infections[31Ács Balázs V.L. Kocsis B. al.Antibacterial selected phase pathogens.BMC 227https://doi.org/10.1186/s12906-018-2291-9Crossref (56) Tea strong effects, capable inactivating influenza nonenveloped coli phage M13, efficiency over 95%[32Usachev Evgeny Pyankov Oleg Usacheva Olga Agranovski Igor vapour.Journal Aerosol Science. 59 0021-8502): 22-30https://doi.org/10.1016/j.jaerosci.2013.01.004Crossref (63) When EO absorbed acts organism, ratio original when absorbed. example, compared single compound component, amount α-pinene liver after inhalation mixed ingredients twice inhalation. comparison components, increased approximately times 1,8-cineole[30Horváth Variations extraction methods, resulting (e.g. friction gnawing), normal vary reasons. presented differently same fraction compounds. Take eucalyptol example: inhibitory capacity seven major revealed docking studies, they ranked according (ΔG), > alpha-pinene alpha-terpineol 3-carene d-limonene o-cymene citronellol. [33Sukanya Panikar Shoba Gunasekaran Arun Jesudass Joseph Sahayarayan Usha Raja Nanthini Arunachalam Chinnathambi Alharbi Sulaiman Nasif Omaima Hak-Jae alternative COVID-19: Molecular interaction protease (Mpro) pharmacokinetics toxicological properties.Journal Infection Public Health. 14 1876-0341): 601-610https://doi.org/10.1016/j.jiph.2020.12.037Crossref (61) eucalyptol, planting highest emission rates 0.16 ± 0.11 nmol m-2 s-1 observed Cinnamomum camphora (Lauraceae)[34Yuan Yali Sun Zhihong Kännaste Astrid Guo Ming Zhou Guomo Niinemets Ülo Isoprenoid emissions leaf form ecology 45 East-Asian subtropical species.Urban Forestry Urban Greening. 53 1618-8667)126705https://doi.org/10.1016/j.ufug.2020.126705Crossref (13) follows perspective, BVOCs both contain (1,8-cineole, eucalyptol). intersections select formulation crucial possibility synergistic[35Fujiwara Ito Synergistic fragrant herbs Japanese scent sachets.Planta 2015 Feb; 81 Feb 25671383): 193-199https://doi.org/10.1055/s-0034-1396138Crossref (15) antagonism. global widely known. Studies restoration forest land globally helps capture atmospheric mitigate climate change [36Bastin J.-F. al.The potential.Science. 365: 76-79Crossref (966) anthropogenic disturbance reserves [37Leslie Muhati Godwin Olago Daniel Olaka Lydia Quantification stocks Mount Marsabit Forest Reserve, sub-humid montane northern Kenya under disturbance.Global Ecology Conservation. 2351-9894)e00383https://doi.org/10.1016/j.gecco.2018.e00383Crossref Data suggest expansion green space generally leads cooling reduced CO2 emissions[38Li Peiyuan Wang Zhi-Hua co-benefits greening mitigating heat emissions.Journal Management. 293 0301-4797)112963https://doi.org/10.1016/j.jenvman.2021.112963Crossref (48) integrate infrastructure high sequestration (CSS) mainstream [39Ariluoma Mari Ottelin Juudit Hautamäki Ranja Tuhkanen Eeva-Maria Mänttäri Miia Carbon residential yards: case Helsinki.Urban 57 1618-8667)126939https://doi.org/10.1016/j.ufug.2020.126939Crossref (45) identify cite more quickly efficiently [40Erfanzadeh Bahrami Motamedi Pétillon Changes soil matter driven shifts co-dominant grassland.Geoderma. 213: 74-78https://doi.org/10.1016/j.geoderma.2013.07.027Crossref (23) Known patterns intercropping superior conventional planting. Piliostigma reticulatum digestive [41Dosso N'guessan B.B. Bidie A.P. Gnangoran B.N. Méité D. Yapo Ehilé E.E. Antidiarrhoeal ethanol extract bark (Caesalpiniaceae) rats.Afr J Tradit 2011 Dec 29; 9 23983341; PMC3746628): 242-249https://doi.org/10.4314/ajtcam.v9i2.9Crossref (20) long-term significantly improved quality nutrients [42Bright M.B.H. Diedhiou Bayala Assigbetse Chapuis-Lardy Ndour Dick R.P. Long-term Sahel: Crop productivity, sequestration, nutrient cycling, quality.Agriculture, Ecosystems Environment. 242: 9-22https://doi.org/10.1016/j.agee.2017.03.007Crossref (34) addition, element greenhouse effect. relationship extremely [43Kuypers Marchant Kartal nitrogen-cycling network.Nat Rev Microbiol. 16: 263-276https://doi.org/10.1038/nrmicro.2018.9Crossref (2211) higher content still help warm [44Goldblatt Colin Claire Mouterde Lenton Timothy Matthews Adrian Watson Andrew Zahnle Kevin Nitrogen-enhanced early Earth.Nature Geoscience. 2009; 2: 891-896https://doi.org/10.1038/ngeo692Crossref (222) Intercropping caused increase available N content, 2008 2010, basil 29.0%, 11.8% 8.2%, respectively[45Chen Xinxin Song Beizhou Yao Yuncong Wu Hongying Hu Jinghui Zhao Lingling related cycling orchard ecosystem.Science Total 472 0048-9697): 939-946https://doi.org/10.1016/j.scitotenv.2013.11.117Crossref While almond intercropped sp. legume citrus, highly efficient irrigated (HEIIS), richness 15%, erosion rate 94%, 50% cropping [46Alcon Francisco Marín-Miñano Cristina Zabala de-Miguel María-Dolores Martínez-Paz Valuing diversification Mediterranean agroecosystems: choice experiment approach.Ecological Economics. 171 0921-8009)106593https://doi.org/10.1016/j.ecolecon.2020.106593Crossref Even crops corn-potato improve humification aromatization dissolved (DOC) at level [47Wang Ding Yi Wenbo Yanli He Shuran Tang Li Yin Xinhua Ping Long Guangqiang application enhance concentration complicated composition.Soil Tillage 210 0167-1987)104979https://doi.org/10.1016/j.still.2021.104979Crossref (27) Other yields contents [48Kolega Simun Miras-Moreno Begona Buffagni Valentina Lucini Luigi Valentinuzzi Fabio Maver Mauro Mimmo Tanja Trevisan Marco Pii Youry Cesco Stefano Nutraceutical Profiles Two Hydroponically Grown Sweet Basil Cultivars Affected Composition Nutrient Solution Inoculation With Azospirillum brasilense.Frontiers 11https://doi.org/10.3389/fpls.2020.596000Crossref (22) aromatization, fixation, promote each certain range. beneficial Trigonella foenum-graecum Cuminum cyminum L., without chemicals[49Rezvani Moghaddam Parviz Moradi Rooholla Mansoori Hamed Influence date, rhizobacteria cumin (Cuminum L.) particular respect infestation Iran.Journal
Language: Английский
Citations
2
Expert Review of Respiratory Medicine, Journal Year: 2024, Volume and Issue: 18(3-4), P. 111 - 125
Published: April 2, 2024
Introduction This review summarizes our current understanding of the respiratory microbiome in COPD and Bronchiectasis. We explore interplay between microbial communities, host immune responses, disease pathology treatment outcomes.
Language: Английский
Citations
2