Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections

Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate bacterial immunotherapies as a complementary tool in our fight against infections. These can activate wide spectrum immunological mechanisms, with trained immunity (TI) being particularly significant. This phenomenon has led to concept immunity-based vaccines (TIbVs), which represent approach vaccinology. We discuss examples TIbVs, including tuberculosis vaccine Bacille Calmette-Guérin (BCG) and polybacterial immunotherapy MV130. From viewpoint, illustrating mode action clinical evidence supports proposal that TIbVs should be considered next-generation confer protection range

Language: Английский

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Hematopoietic stem cell state and fate in trained immunity

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 14, 2025

Language: Английский

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Sarcoidosis immunopathogenesis – a new concept of maladaptive trained immunity

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(6), P. 406 - 418

Published: May 24, 2024

Language: Английский

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Identification and evolution characteristics of STAT gene family and the role of STAT1 and STAT3 in trained immunity in largemouth bass (Micropterus salmoides)

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742117 - 742117

Published: Jan. 1, 2025

Language: Английский

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Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Central trained immunity and its impact on chronic inflammatory and autoimmune diseases

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 154(5), P. 1113 - 1116

Published: June 12, 2024

Language: Английский

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The immunomodulatory and antioxidant effects of β-glucans in invertebrates

Journal of Invertebrate Pathology, Journal Year: 2023, Volume and Issue: 201, P. 108022 - 108022

Published: Nov. 1, 2023

Language: Английский

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Why It Remains Statistically Probable That SARS-CoV-2 Was Isolated and Then Accidentally Lab-Leaked before the First COVID-19 Outbreak

Published: June 20, 2024

The SARS-CoV-2-induced acute COVID-19 pandemic disorder seems to have begun all of the sudden in 2020, with very little data available regarding prior times which people experienced mysterious flu-like illness symptoms characteristic disease. scientific community be divided into a few parts regards belief kind viral origins. A significant number scientists believe that virus solely has natural origins and it underwent thorough process zoonosis, independent laboratory research-based research would only catalyse zoonosis due helping gain additional function transmission virulence. Many other wide “gain-of-function” research, whilst many most genome origins, zoonotic having been artificially catalysed its latter part humans. Considerable extent evidence suggests restricted, but considerable accidentally leaked nearby environment, spillover humans was influenced by such events, given for example multidimensional pathogenetic displayed main antigen action, spike glycoprotein, causing kinds immune pathophysiology - including transient immunosuppression. Investigations novel coronavirus lasting years, seemingly no concrete end sight, molecular testing methods detect SARS-CoV-2 infection displaying less than perfect results not significantly helped process. Evidence even started pointing toward existence artificial, exposing probable accidentally-induced artificial “accelerated evolution”, could particularly dangerous because nature pathogenic agent. Likewise, is possible prevention distribution scenarios as fact constitutes censorship, rather regulation may considered based. Simultaneously, important regard hypotheses preliminary reports evidence-based, ensure diligence performed cases. integrity ultimately innovation medical solutions depends on democracy rule law, well regulating partnerships companies from world nations where autocracy rules their society.

Language: Английский

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Why It Remains Statistically Probable That SARS-CoV-2 Was Isolated and Then Accidentally Lab-Leaked before the First COVID-19 Outbreak

Published: June 19, 2024

The SARS-CoV-2-induced acute COVID-19 pandemic disorder seems to have begun all of the sudden in 2020, with very little data available regarding prior times which people experienced mysterious flu-like illness symptoms characteristic disease. scientific community be divided into a few parts regards belief kind viral origins. A significant number scientists believe that virus solely has natural origins and it underwent thorough process zoonosis, independent laboratory research-based research would only catalyse zoonosis due helping gain additional function transmission virulence. Many other wide “gain-of-function” research, whilst many most genome origins, zoonotic having been artificially catalysed its latter part humans. Considerable extent evidence suggests restricted, but considerable accidentally leaked nearby environment, spillover humans was influenced by such events, given for example multidimensional pathogenetic displayed main antigen action, spike glycoprotein, causing kinds immune pathophysiology - including transient immunosuppression. Investigations novel coronavirus lasting years, seemingly no concrete end sight, molecular testing methods detect SARS-CoV-2 infection displaying less than perfect results not significantly helped process. Evidence even started pointing toward existence artificial, exposing probable accidentally-induced artificial “accelerated evolution”, could particularly dangerous because nature pathogenic agent. Likewise, is possible prevention distribution scenarios as fact constitutes censorship, rather regulation may considered based. Simultaneously, important regard hypotheses preliminary reports evidence-based, ensure diligence performed cases. integrity ultimately innovation medical solutions depends on democracy rule law, well regulating partnerships companies from world nations where autocracy rules their society.

Language: Английский

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Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting

Current Opinion in Chemical Biology, Journal Year: 2024, Volume and Issue: 82, P. 102521 - 102521

Published: Aug. 29, 2024

Lectin–glycan interactions play a crucial role in the immune system. An important class of lectins innate system is myeloid C-type lectin receptors (CLRs). Myeloid CLRs act as pattern recognition and are predominantly expressed by cells, such macrophages, dendritic neutrophils. In immunity, contribute to self/non-self discrimination. While pathogen-associated molecular patterns (PAMPs) may protective response, CLR engagement can also be exploited pathogens for evasion. Since various endocytic trigger distinct signaling pathways targeting has proven useful drug/antigen delivery into antigen-presenting cells modulation responses. This review covers recent discoveries pathogen/CLR novel approaches within period past two years. • (CLRs) pathogen sensors immunity. cell-specific antigen/drug delivery. Multivalent glycan display on carrier systems facilitates targeting. studies (mainly years) research.

Language: Английский

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