Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(3), P. 531 - 531
Published: March 6, 2024
Atopic
dermatitis
(AD)
is
a
chronic
and
relapsing
inflammatory
cutaneous
disease.
The
role
of
host
defense
microbial
virulence
factors
in
Staphylococcus
aureus
skin
colonization,
infection,
inflammation
perpetuation
AD
remains
an
area
current
research
focus.
Extracellular
vesicles
(EV)
mediate
cell-to-cell
communication
by
transporting
delivering
bioactive
molecules,
such
as
nucleic
acids,
proteins,
enzymes,
to
recipient
cells.
spontaneously
secretes
extracellular
(SA-derived
EVs),
which
spread
throughout
the
layers.
Previous
has
shown
that
SA-derived
EVs
from
patients
can
trigger
cytokine
secretion
keratinocytes,
shape
recruitment
neutrophils
monocytes,
induce
AD-type
lesions
mouse
models,
addition
their
exogenous
worsening
for
In
this
review
article,
we
aim
examine
physiopathology
its
progression,
highlighting
recent
field
exploring
potential
crosstalk
between
microbiota.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 11293 - 11303
Published: Nov. 1, 2024
Abstract:
The
incidence
of
chronic
wounds
is
steadily
increasing
each
year,
yet
conventional
treatments
for
yield
unsatisfactory
results.
delayed
healing
significantly
affects
patient
quality
life,
placing
a
heavy
burden
on
patients,
their
families,
and
the
healthcare
system.
Therefore,
there
an
urgent
need
to
find
new
treatment
methods
wounds.
Plant-derived
exosome-like
nanovesicles
(PELNs)
may
be
able
accelerate
wound
healing.
PELNs
possess
advantages
such
as
good
accessibility
(due
in
part
high
isolation
yields),
low
immunogenicity,
stability.
Currently,
are
limited
reports
regarding
role
associated
mechanisms,
highlighting
novelty
necessity
further
research.
This
review
aims
provide
overview
PELNs,
discussing
methods,
composition,
mechanisms
action
Finally,
we
summarize
future
opportunities
challenges
related
use
wounds,
offer
some
insights
solutions.
Keywords:
exosomes,
nanovesicles,
plants,
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(3), P. 531 - 531
Published: March 6, 2024
Atopic
dermatitis
(AD)
is
a
chronic
and
relapsing
inflammatory
cutaneous
disease.
The
role
of
host
defense
microbial
virulence
factors
in
Staphylococcus
aureus
skin
colonization,
infection,
inflammation
perpetuation
AD
remains
an
area
current
research
focus.
Extracellular
vesicles
(EV)
mediate
cell-to-cell
communication
by
transporting
delivering
bioactive
molecules,
such
as
nucleic
acids,
proteins,
enzymes,
to
recipient
cells.
spontaneously
secretes
extracellular
(SA-derived
EVs),
which
spread
throughout
the
layers.
Previous
has
shown
that
SA-derived
EVs
from
patients
can
trigger
cytokine
secretion
keratinocytes,
shape
recruitment
neutrophils
monocytes,
induce
AD-type
lesions
mouse
models,
addition
their
exogenous
worsening
for
In
this
review
article,
we
aim
examine
physiopathology
its
progression,
highlighting
recent
field
exploring
potential
crosstalk
between
microbiota.
