Pathogens, Journal Year: 2024, Volume and Issue: 13(4), P. 338 - 338
Published: April 19, 2024
New evidence has suggested that oral and gut microflora may have significant impacts on the predisposition, development, stability of obesity in adults over time-although less is known about this phenomenon children. Compared with healthy-weight controls, overweight obese adult patients are now to harbor specific pathogens, such as
Language: Английский
Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(9)
Published: Feb. 27, 2025
Mimicking metabolic pathways on electrodes enables in vivo metabolite monitoring for decoding metabolism. Conventional sensors cannot accommodate underlying complex reactions involving multiple enzymes and cofactors, addressing only a fraction of enzymatic few metabolites. We devised single-wall-carbon-nanotube-electrode architecture supporting tandem pathway–like linkable to oxidoreductase-based electrochemical analysis, making vast majority metabolites detectable vivo. This robustly integrates self-mediates at maximum enzyme capacity, facilitates intermediation/detection interference inactivation through multifunctional use. Accordingly, we developed targeting 12 metabolites, with 100-fold-enhanced signal-to-noise ratio days-long stability. Leveraging these sensors, monitored trace endogenous sweat/saliva noninvasive health monitoring, bacterial the brain, marking key milestone unraveling gut microbiota–brain axis dynamics.
Language: Английский
Citations
0
Chinese Science Bulletin (Chinese Version), Journal Year: 2025, Volume and Issue: 70(10), P. 1446 - 1459
Published: Jan. 22, 2025
Language: Английский
Citations
0
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118183 - 118183
Published: April 18, 2025
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: April 22, 2025
The role of the respiratory microbiome in lung diseases is increasingly recognized, with potential migration pathogens being a significant clinical consideration. Despite its importance, evidence elucidating this phenomenon remains scarce. This prospective study collected samples from patients suspected lower tract infections (LRTI), including oropharyngeal swabs (OPS), sputum, and bronchoalveolar lavage fluid (BALF). Metagenomic next-generation sequencing (mNGS) was employed to analyze microbial diversity, complemented by Bayesian source tracking sequence alignment analyses explore pathogen patterns. A cohort 68 enrolled, 56 diagnosed LRTI 12 non-infectious conditions. statistically disparity diversity observed between infected non-infected groups (p < 0.05). Intriguingly, no variations community structure, alpha beta were detected across different sites within individuals. analysis revealed pronounced pattern among compared overall community, ratios 51.54% 1.92%, respectively Sequence similarity further corroborated these findings, highlighting notable homology specific migrating pathogens. represents pioneering effort deducing patterns through analysis. findings provide novel insights that could significantly advance diagnostics therapeutic strategies for infections.
Language: Английский
Citations
0
Pathogens, Journal Year: 2024, Volume and Issue: 13(4), P. 338 - 338
Published: April 19, 2024
New evidence has suggested that oral and gut microflora may have significant impacts on the predisposition, development, stability of obesity in adults over time-although less is known about this phenomenon children. Compared with healthy-weight controls, overweight obese adult patients are now to harbor specific pathogens, such as
Language: Английский
Citations
2