Interbacterial warfare in the human gut: insights from Bacteroidales’ perspective

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 4, 2025

Competition and cooperation are fundamental to the stability evolution of ecological communities. The human gut microbiota, a dense complex microbial ecosystem, plays critical role in host's health disease, with competitive interactions being particularly significant. As dominant extensively studied group gut, Bacteroidales serves as successful model system for understanding these intricate dynamic processes. This review summarizes recent advances our antagonism mechanisms among at biochemical or molecular-genetic levels, focusing on interference exploitation competition. We also discuss unresolved questions suggest strategies studying Bacteroidales. presented here offers valuable insights into molecular basis bacterial may inform manipulating microbiome benefit health.

Language: Английский

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Chemical Composition of Cynanchum auriculatum Royle Ex Wight and Its Potential Role in Ameliorating Colitis

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

ABSTRACT Cynanchum auriculatum Royle ex Wight, commonly known as “Baishouwu,” has been traditionally used in China for its medicinal and dietary benefits. Despite long history of use, the potential therapeutic effects C. treatment colitis have not fully investigated. This study aims to evaluate water extract root on elucidate mechanisms action. The (CW) was prepared characterized using UPLC‐Q‐TOF‐MS, identifying thirty‐two distinct compounds, including saponins, organic acids, fatty acid derivatives, alkaloids. efficacy CW assessed a mouse model. significantly alleviated symptoms, evidenced by increased colon length, reduced disease activity indices, decreased tissue damage. colonic inflammatory cytokine production enhanced expression tight junction proteins, claudin‐1, occludin, ZO‐1, thereby strengthening intestinal barrier integrity. Additionally, modulated gut microbiota increasing microbial diversity, promoting beneficial Lactobacillus growth, reducing pathogenic Pseudomonas levels, enhancing short‐chain production. results suggest that exhibits significant management attenuating inflammation, restoring function, modulating microbiota. These findings provide basis further exploration functional food prevention colitis.

Language: Английский

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Comparing Campylobacter jejuni to three other enteric pathogens in OligoMM ¹² mice reveals pathogen-specific host and microbiota responses

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 21, 2025

Campylobacter jejuni, non-typhoidal Salmonella spp., Listeria monocytogenes and enteropathogenic/enterohemorrhagic Escherichia coli (EPEC/EHEC) are leading causes of food-borne illness worldwide. Citrobacter rodentium has been used to model EPEC EHEC infection in mice. The gut microbiome is well-known affect colonization host responses many pathogens. Recent progress established gnotobiotic mice as valuable models study how microbiota the enteric infections by S. Typhimurium, C. L. monocytogenes. However, for we still lacking a suitable mouse model. Moreover, limited comparability data across laboratories often negatively affected variations between different research facilities or murine microbiotas. In this study, applied standardized OligoMM12 compared same facility. We provide evidence robust significant pathological changes following with these offer insights into pathogen-specific metabolite signatures, highlighting advantages direct comparisons factors influencing pathogenesis major Notably, reveal first time that jejuni stably colonizes mice, triggering inflammation. Additionally, our comparative approach successfully identifies responses, including detection genes uniquely associated humans. These findings underscore potential versatile tool advancing understanding pathogen interactions.

Language: Английский

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Digestion Characteristics and Probiotic Activity of An Tea Polysaccharides: Promoting Lactobacillus and Bifidobacterium In Vitro and In Vivo

Fermentation, Journal Year: 2025, Volume and Issue: 11(2), P. 97 - 97

Published: Feb. 14, 2025

An tea is highly valued for its unique post-fermentation process, which enriches flavor and aroma. In this study, the digestion fermentation characteristics of polysaccharides (ATPSs) were investigated in vitro. The results indicated that molecular weight sugar content ATPSs remained unchanged during simulated saliva, gastric, small intestinal but reduced fermentation, suggesting could pass digestive system be metabolized by gut microbiota. Notably, modulated microbiota, reducing pathogenic bacteria such as Desulfovibrio Escherichia, while enhancing beneficial genera like Lactobacillus, Bifidobacterium, Prevotella, alongside an increase short-chain fatty acids (SCFAs). vivo experiments on C57BL/6J mice demonstrated promoted levels Lactobacillus Bifidobacterium. These findings suggest serve a potential prebiotic to improve human health modulating

Language: Английский

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Effect of diet-induced low-grade, chronic inflammation on susceptibility of broilers to Salmonella colonization and pathogenicity

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105303 - 105303

Published: May 1, 2025

Language: Английский

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Microbial metabolism of host-derived antioxidants

Current Opinion in Chemical Biology, Journal Year: 2024, Volume and Issue: 84, P. 102565 - 102565

Published: Dec. 24, 2024

Language: Английский

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