American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 121(2), P. 470 - 477
Published: Dec. 18, 2024
Language: Английский
Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Language: Английский
Citations
2
Nature Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Language: Английский
Citations
1
MedComm, Journal Year: 2025, Volume and Issue: 6(5)
Published: April 18, 2025
ABSTRACT Dysbiosis refers to the disruption of gut microbiota balance and is pathological basis various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, metabolic abnormalities. These involve dysfunctions in gut–brain axis, gut–liver others cause broader effects. Although association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding specific treatment strategies. This review begins examining causes summarizes potential representative imbalance. It integrates clinical evidence explore preventive therapeutic strategies targeting emphasizing importance understanding dysbiosis. Finally, we summarized development artificial intelligence (AI) research suggested that it will play a critical role future studies on combining multiomics technologies AI further uncover complex drive personalized
Language: Английский
Citations
1
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 652 - 652
Published: Feb. 1, 2025
Cereals are among the foods rich in myo-inositol hexakisphosphate (phytic acid, IP6), lower phosphates (IPx), a wide range of phenolic compounds, as well vitamins, minerals, oligosaccharides, phytosterols and para-aminobenzoic attributed with multiple bioactivities, particularly associated prevention metabolic syndrome colon cancer. The bran fraction wheat, maize, brown rice other cereals contains high levels phytate, free total phenolics, endogenous enzymes such amylases, phytase, xylanase, β-glucanase feruloyl esterase, whose activities can be increased by germination. preliminary steps digestion begin oral cavity where substrates for action cereal salivary start to released from food matrix. IP6 phytate complexes arabinoxylans, starch protein bodies would eventually enhance absorption nutrients, including regulating tight junctions and, together ferulic acid (FA), maintain cell barrier integrity epithelial antibacterial immunity. In addition, both FA exert potent complementary antioxidant effects, while IPx generated through advanced hydrolysis microbial phytases may affect digestive enzyme activity incretin secretion, resulting modulated insulin glucagon release various diabetic complications. Contrary widespread negative attitudes towards this review, we present strategy selecting content, esterase endoxylanase activities, produce value-added health-promoting foods. compounds and/or generate substantial amounts “enzymatically inositol” (EGI), IP6, myo-inositol, that, FA, provide enhanced bioavailability nutrients synergistic effects not previously realised.
Language: Английский
Citations
0
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 6, 2025
The gut microbiome is altered after bariatric surgery and associated with weight loss. However, the commensal bacteria involved underlying mechanism remain to be determined. We performed shotgun metagenomic sequencing in obese subjects before longitudinally sleeve gastrectomy (SG), found a significant enrichment microbial species Clostridia bile acid metabolizing genes SG treatment. Bile profiling further revealed decreased primary acids (PBAs) increased conjugated secondary (C-SBAs) SG. Specifically, glycodeoxycholic (GDCA) taurodeoxycholic (TDCA) were at different follow-ups SG, abundance of body reduction. Fecal transplantation post-SG feces SBA levels, alleviated gain recipient mice. Furthermore, both Clostridia-enriched spore-forming GDCA supplementation expression responsible for lipolysis fatty oxidation adipose tissue reduced adiposity via Takeda G-protein-coupled receptor 5 (TGR5) signaling. Our findings reveal C-SBAs as contributory SG-induced loss, part TGR5 signaling, suggest SBA-producing microbes potential therapeutic target obesity intervention.
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: March 11, 2025
Polycystic ovary syndrome (PCOS) is a highly heterogeneous metabolic disorder, with oligomenorrhea and hirsutism as patients’ primary complaints. Hyperinsulinemia crucial pathophysiological mechanism in the development of PCOS, 50-70% patients exhibiting insulin resistance (IR). This condition not only exacerbates ovulatory dysfunction but also leads to various adverse outcomes, such dyslipidemia diabetes, increases risk cardiovascular events both before after menopause. Gut microbiota microbial community within host that possesses significant potential shaped by external environmental factors, neuro-immune network, metabolism. Recent studies have shown gut dysbiosis closely related progression PCOS. Despite growing recognition role pathogenesis treatment its clinical application remains infancy. Currently, most guidelines expert consensus still emphasize traditional therapeutic approaches, hormonal treatments, lifestyle modifications, sensitizers. However, accumulating evidence suggests may influence reproductive health PCOS through mechanisms. Therefore, understanding between IR essential. review describes changes IR-PCOS patients, examines mechanisms which contributes updates supporting regulatory target IR-PCOS. In summary, be involved improving offer stability benefits.
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106436 - 106436
Published: March 1, 2025
Language: Английский
Citations
0
BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 12, 2025
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: April 23, 2025
Obesity is increasingly becoming a challenge with China's economic development. There an urgent need to identify more affordable methods combat this condition. Paederia scandens (PS), cost-effective herbal remedy widely used in China for treating inflammation and pain, shows potential regard. To investigate its anti-obesity mechanisms, we established high-fat diet (HFD)-induced obesity model mice. The obese mice subsequently received daily oral gavage of PS extract 21 consecutive days. Upon the completion experiment, blood samples were collected analyze lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density (LDL-C). Abdominal adipose tissue was subjected hematoxylin-eosin (HE) staining histological analysis, while fecal underwent 16S rRNA sequencing assess gut microbiota composition. Our findings revealed that supplementation significantly reduced body weight, metabolism biomarkers, adipocyte size. treatment also restored microbial diversity, 19 specific taxa 25 KEGG pathways identified as mediators effects. Notably, modulated key obesity-associated microbiota, Alistipes, Lachnoclostridium, Odoribacter, Prevotellaceae UCG-001, Rikenellaceae RC9-gut group, norank_g Bacteroidales S24-7 group. Serum metabolomics analysis implicated L-ascorbic acid, stevioside, allopurinol, gingerol, along amino acid energy pathways, mechanism PS. These results provide novel theoretical insights into therapeutic prevention treatment.
Language: Английский
Citations
0
Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109512 - 109512
Published: May 1, 2025
Microplastics (MPs) and antibiotic tetracycline (TC) are widespread in the environment constitute emerging combined contaminants. Young individuals particularly vulnerable to agents that disrupt intestinal health development. However, effects of MPs TC remain poorly understood. In this study, we developed a young mouse model exposed polystyrene MPs, either alone or combination with for 8 weeks simulate real-life dietary exposure during early life. Our findings revealed concurrent caused most severe barrier dysfunction driven by inflammatory activation oxidative imbalance. Moreover, reduced abundance potential probiotics while promoting growth opportunistic pathogens. Metagenomic analysis further indicated co-exposure enhanced bacteria carrying resistance genes (ARGs) virulence factor (VFGs), contributing dissemination potentially harmful genes. Finally, strong positive correlation was observed between microbiota dysbiosis, ARGs, VFGs. general, study highlighted hazards antibiotics mice, which provided new perspective into dynamics pathogens, VFGs early-life environments.
Language: Английский
Citations
0