Breastfeeding, Human Milk and Allergic Disease: Findings from the CHILD Cohort Study

Published: Jan. 6, 2025

first_page Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Size: Aa Line Spacing:  Column Width:  Background: Open AccessAbstract Breastfeeding, Human Milk and Allergic Disease: Findings from the CHILD Cohort Study † by Meghan B. AzadMeghan Azad SciProfiles Scilit Preprints.org Google Scholar 1,2 1 Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada 2 Department Pediatrics Child Health, University R3T 2N2, Presented at Australian Breastfeeding + Science Translation Conference (ABREAST 2024), Perth, Australia, 15 November 2024. Proceedings 2025, 112(1), 13; https://doi.org/10.3390/proceedings2025112013 Published: 6 January 2025 keyboard_arrow_down with Cover XML Versions Notes Keywords: breastfeeding; human milk; allergic disease; asthma; food allergy; microbiome; immunity; substantially contributes to infant microbiome immune development, influencing lifelong health trajectories, including disease risk. However, nuances these relationships underlying mechanisms are not fully understood. The (www.childstudy.ca) follows 3500 Canadian families pregnancy through adolescence understand developmental origins asthma, allergies, other chronic conditions. Within CHILD, feeding practices (e.g., exclusivity, duration, mode milk feeding) composition microbiota, oligosaccharides, nutrients, bioactive proteins) studied their contributions development health. findings show that breastfeeding shapes [1,2,3,4] serum biomarker profiles in first year life [5]. appears protect against childhood asthma a dose-dependent manner is strongest direct nursing (vs. pumped breastmilk) [6] partially mediated nasal gut microbiomes [7]. combination maternal peanut consumption time introduction during infancy associated lower risk sensitization 5 years age [8]. Using approaches interrogate as complex biological system (rather than discrete individual components) [9,10], phenotypes have been specific combinations oligosaccharides [11], polyunsaturated fatty acids [12], microbiota [13,14]. In conclusion, has identified practices, components, related may contribute or prevention phenotypes. Expansion this research could identify new therapeutic targets strategies. FundingM.B.A. holds Chair Early Nutrition Developmental Origins Health Disease fellow CIFAR Humans Microbiome Program. was established funding Institutes Allergy, Genes, Environment Network Centres Excellence. analysis samples data, for studies summarized here, funded variety sources, each listed cited publications.Institutional Review Board StatementCHILD protocols were approved Ethics Boards McMaster University, Sick Children, Universities Alberta, British Columbia.Informed Consent StatementInformed consent obtained all participating mothers enrollment.Data Availability data available registration database (https://childstudy.ca/childdb/) submission formal request.AcknowledgmentsWe thank (CHILD) participant dedication commitment advancing research.Conflicts InterestM.B.A. consulted DSM Nutritional Products, serves on scientific advisory board TinyHealth, received speaking honoraria Prolacta Biosciences. She contributed without remuneration online courses breast produced Courses. For funders had no role design study; collection, analyses, interpretation data; writing manuscript; decision publish results.ReferencesDai, D.L.Y.; Petersen, C.; Hoskinson, Del Bel, K.L.; Becker, A.B.; Moraes, T.J.; Mandhane, P.J.; Finlay, B.B.; Simons, E.; Kozyrskyj, A.L.; et al. enrichment longum subsp. infantis mitigates effect antibiotics Med 2023, 4, 92–112.e5. [Google Scholar] [CrossRef]Fehr, K.; Moossavi, S.; Sbihi, H.; Boutin, R.C.T.; Bode, L.; Robertson, B.; Yonemitsu, Field, C.J.; Breastmilk co-occurrence bacteria mothers' gut: Study. Cell Host Microbe 2020, 28, 285–297.e4. [CrossRef] [PubMed]Forbes, J.D.; Azad, M.B.; Vehling, Tun, H.M.; Konya, T.B.; Guttman, D.S.; Lefebvre, D.; Sears, M.R.; Association exposure formula hospital subsequent overweight life. JAMA Pediatr. 2018, 172, e181161. [PubMed]Azad, T.; Maughan, Chari, R.S.; Scott, J.A.; Gut healthy infants: Profiles delivery diet 4 months. CMAJ 2013, 185, 385–394. [PubMed]Ames, S.R.; Lotoski, L.C.; Rodriguez, Brodin, P.; Turvey, S.E.; Subbarao, M.B. one-year-old infants birth cohort study. Am. J. Clin. Nutr. 121, 60–73. [PubMed]Klopp, A.; D.L.; Investigators; Modes asthma: A prospective 2017, 190, 192–199.e2. [PubMed]Shenhav, Fehr, Reyna, M.E.; Dai, R.; Breton, V.; Rossi, Smieja, M.; Microbial colonization programs structured guide respiratory development. 2024, 187, 5431–5452.e20. [CrossRef]Azad, Dharma, Tran, Marshall, J.; Reduced early while breastfeeding. Dev. Orig. Dis. 2021, 12, 811–818. [CrossRef]Shenhav, community ecology theory computational methods study system. mSystems. 2022, 7, e01132-21. [PubMed]Becker, Goguen, Miliku, Multimodal machine learning modeling head circumference, composition, shared environment. Sci. Rep. 14, 2977. [PubMed]Miliku, Sharma, A.K.; oligosaccharide among Allergy 73, 2070–2073. Richelle, Stuart, T.E.; Sex-specific associations long-chain Immunol. 32, 1173–1182. [PubMed]Fang, Z.Y.; Stickley, S.A.; Ambalavanan, Zhang, Y.; Zacharias, A.M.; Networks host genomics, sensitization. 1838–1852.e5. [PubMed]Ambalavanan, Chang, Choi, Fang, genetics milk-fed children. Nat. Commun. 15, 7735. [PubMed]Disclaimer/Publisher's Note: statements, opinions contained publications solely those author(s) contributor(s) MDPI and/or editor(s). editor(s) disclaim responsibility any injury people property resulting ideas, methods, instructions products referred content. © author. Licensee MDPI, Basel, Switzerland. This article an open access distributed under terms conditions Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Share Cite ACS Style 112, 13. AMA MB. Proceedings. 2025; 112(1):13. Chicago/Turabian 2025. "Breastfeeding, Study" no. 1: APA M. (2025). Proceedings, Metrics No Access Statistics Multiple requests same IP address counted one view.

Language: Английский

Unveiling early-life microbial colonization profile through characterizing low-biomass maternal-infant microbiomes by 2bRAD-M

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Introduction The microbial composition of human breast milk and infant meconium offers critical insights into the early colonization profile, it greatly contributes to infant’s immune system long-term health outcomes. However, analyzing these samples often faces technical challenges limitations low-resolution using conventional approaches due their low biomass. Methods Here, we employed type IIB restriction enzymes site-associated DNA sequencing for microbiome (2bRAD-M) as a reduced metagenomics method address issues profile species-level composition. We collected samples, maternal feces, meconium, comparing results from 2bRAD-M with those both commonly used 16S rRNA amplicon gold-standard whole (WMS). Results accuracy robustness were demonstrated through its consistently high correlation individual abundance whole-community-level distance paired WMS samples. Moreover, enabled us identify clinical variables associated microbiota variations significant changes in diversity across different lactation stages milk. Discussion This study underscores importance employing future large-scale longitudinal studies on microbiomes, thereby enhancing our understanding life demonstrating further translational potential.

Language: Английский

Lactobacillus rhamnosus RL-H3-005 and Pediococcus acidilactici RP-H3-006 ameliorate Atopic Dermatitis in offspring mice by modulating the gut microbiota

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105348 - 105348

Published: Oct. 1, 2024

Language: Английский