Chinese Journal of Chromatography,
Journal Year:
2024,
Volume and Issue:
42(11), P. 1087 - 1093
Published: Oct. 31, 2024
Metal
organic
frameworks
(MOFs)
are
crystalline
compounds
composed
of
metal
ions
(or
clusters)
and
ligands.
Chiral
MOFs
have
been
successfully
utilized
as
novel
materials
for
the
separation
chiral
enantiomers
by
chromatography,
demonstrating
excellent
performance.
In
this
study,
a
MOF-modified
silica
monolithic
capillary
column
was
used
pressurized
electrochromatography.
First,
MOF
(Co-glycyl-L-glutamic
acid,
Co-L-GG)
synthesized.
This
then
to
prepare
via
one-step
in
situ
polymerization
method.
The
optimal
conditions
preparing
were
determined
follows:
Co-L-GG
amount,
5
mg;
polyethylene
glycol
0.96
tetramethoxysilane
dosage,
3.6
mL;
trimethoxymethylsilane
0.4
mL.
Next,
effects
on
drugs
investigated.
Under
an
applied
voltage
-20
kV
mobile
phase
consisting
acetonitrile
20
mmol/L
disodium
hydrogen
phosphate
(80∶20,
v/v),
six
separated
within
3
min,
with
baseline
achieved
amlodipine,
fluvastatin,
tryptophan.
Moreover,
prepared
exhibited
good
reproducibility
stability.
Finally,
molecular
docking
studies
conducted
using
AutoDock
explore
recognition
mechanism,
results
analyzed
Discovery
Studio.
indicated
that
larger
differences
binding
free
energy
between
correlated
higher
enantioselectivity
factors.
However,
correlation
did
not
necessarily
lead
increase
resolution.
Co-L-GG,
which
is
enriched
primary
amines,
secondary
carbonyl
groups,
demonstrated
enantiomeric
capability.
conclusion,
study
demonstrates
can
be
effectively
functional
monomers
columns,
highlighting
their
significant
potential
analysis
compounds.
comprehensive
exploration
synthesis,
characterization,
applications
these
will
help
provide
valuable
insights
into
development
advanced
technologies.
Electroanalysis,
Journal Year:
2024,
Volume and Issue:
36(5)
Published: Jan. 30, 2024
Abstract
A
voltammetric
sensor
comprising
a
paste
electrode
made
of
graphitized
thermal
carbon
black
CarboblackC
and
nanosized
zeolite
MFI
was
developed
for
selective
recognition
determination
tryptophan
enantiomers.
It
found
that
in
determining
enantiomers,
the
dependence
remains
linear
at
concentrations
from
5×10
−5
to
1×10
−3
M.
The
detection
limits
L‐
D‐enantiomers
were
calculated
be
4.98×10
−7
M
3.20×10
M,
while
their
lower
determinable
concentrations–1.66×10
−6
1.07×10
respectively.
is
more
sensitive
D‐tryptophan
(Δ
E
p
=20
mV,
i
pD
/
pL
=1.58).
shown
successfully
determine
enantiomers
model
solutions
pure
mixture
biological
fluids,
tablet
forms
biologically
active
additives.
suggested
it
possible
ratio
with
high
probability.
TrAC Trends in Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
171, P. 117486 - 117486
Published: Dec. 15, 2023
Over
years,
magnetic
materials
have
gained
special
attention
since
they
offer
a
versatile
and
powerful
tool
in
sorbent-based
dispersive
(micro)extraction
techniques,
allowing
more
efficient
effective
sample
preparation.
Apart
from
the
fast
handling
collection
of
sorbent
during
this
stage,
use
sorbents
has
led
to
development
miniaturized
microextraction
which
gains
relevance
bioanalysis
volumes
are
sometimes
scarce.
Additionally,
wide
variety
currently
available
allows
enhance
selectivity
extraction
can
be
conveniently
functionalized,
improving
interaction
with
analytes.
In
context,
paper
provides
an
overview
used
techniques
for
enrichment
target
compounds
biological
samples,
describing
their
main
features
synthetic
pathways
magnetization,
without
obviating
limitations.
