Chinese Journal of Chromatography,
Journal Year:
2024,
Volume and Issue:
42(11), P. 1087 - 1093
Published: Oct. 31, 2024
Metal
organic
frameworks
(MOFs)
are
crystalline
compounds
composed
of
metal
ions
(or
clusters)
and
ligands.
Chiral
MOFs
have
been
successfully
utilized
as
novel
materials
for
the
separation
chiral
enantiomers
by
chromatography,
demonstrating
excellent
performance.
In
this
study,
a
MOF-modified
silica
monolithic
capillary
column
was
used
pressurized
electrochromatography.
First,
MOF
(Co-glycyl-L-glutamic
acid,
Co-L-GG)
synthesized.
This
then
to
prepare
via
one-step
in
situ
polymerization
method.
The
optimal
conditions
preparing
were
determined
follows:
Co-L-GG
amount,
5
mg;
polyethylene
glycol
0.96
tetramethoxysilane
dosage,
3.6
mL;
trimethoxymethylsilane
0.4
mL.
Next,
effects
on
drugs
investigated.
Under
an
applied
voltage
-20
kV
mobile
phase
consisting
acetonitrile
20
mmol/L
disodium
hydrogen
phosphate
(80∶20,
v/v),
six
separated
within
3
min,
with
baseline
achieved
amlodipine,
fluvastatin,
tryptophan.
Moreover,
prepared
exhibited
good
reproducibility
stability.
Finally,
molecular
docking
studies
conducted
using
AutoDock
explore
recognition
mechanism,
results
analyzed
Discovery
Studio.
indicated
that
larger
differences
binding
free
energy
between
correlated
higher
enantioselectivity
factors.
However,
correlation
did
not
necessarily
lead
increase
resolution.
Co-L-GG,
which
is
enriched
primary
amines,
secondary
carbonyl
groups,
demonstrated
enantiomeric
capability.
conclusion,
study
demonstrates
can
be
effectively
functional
monomers
columns,
highlighting
their
significant
potential
analysis
compounds.
comprehensive
exploration
synthesis,
characterization,
applications
these
will
help
provide
valuable
insights
into
development
advanced
technologies.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(12), P. 2794 - 2794
Published: June 12, 2024
The
preparation
and
application
of
the
composite
material
"crosslinked
polyvinyl
alcohol-magnetite"
as
a
sensitive
matrix
for
use
in
digital
colorimetry
optical
micrometry
methods
are
discussed.
was
synthesized
form
spherical
granules
(for
micrometry)
thin
films
colorimetry).
obtained
composites
were
characterized
by
registration
magnetization
curves.
It
shown
that
amount
grown
Fe
Chinese Journal of Chromatography,
Journal Year:
2024,
Volume and Issue:
42(11), P. 1087 - 1093
Published: Oct. 31, 2024
Metal
organic
frameworks
(MOFs)
are
crystalline
compounds
composed
of
metal
ions
(or
clusters)
and
ligands.
Chiral
MOFs
have
been
successfully
utilized
as
novel
materials
for
the
separation
chiral
enantiomers
by
chromatography,
demonstrating
excellent
performance.
In
this
study,
a
MOF-modified
silica
monolithic
capillary
column
was
used
pressurized
electrochromatography.
First,
MOF
(Co-glycyl-L-glutamic
acid,
Co-L-GG)
synthesized.
This
then
to
prepare
via
one-step
in
situ
polymerization
method.
The
optimal
conditions
preparing
were
determined
follows:
Co-L-GG
amount,
5
mg;
polyethylene
glycol
0.96
tetramethoxysilane
dosage,
3.6
mL;
trimethoxymethylsilane
0.4
mL.
Next,
effects
on
drugs
investigated.
Under
an
applied
voltage
-20
kV
mobile
phase
consisting
acetonitrile
20
mmol/L
disodium
hydrogen
phosphate
(80∶20,
v/v),
six
separated
within
3
min,
with
baseline
achieved
amlodipine,
fluvastatin,
tryptophan.
Moreover,
prepared
exhibited
good
reproducibility
stability.
Finally,
molecular
docking
studies
conducted
using
AutoDock
explore
recognition
mechanism,
results
analyzed
Discovery
Studio.
indicated
that
larger
differences
binding
free
energy
between
correlated
higher
enantioselectivity
factors.
However,
correlation
did
not
necessarily
lead
increase
resolution.
Co-L-GG,
which
is
enriched
primary
amines,
secondary
carbonyl
groups,
demonstrated
enantiomeric
capability.
conclusion,
study
demonstrates
can
be
effectively
functional
monomers
columns,
highlighting
their
significant
potential
analysis
compounds.
comprehensive
exploration
synthesis,
characterization,
applications
these
will
help
provide
valuable
insights
into
development
advanced
technologies.
