Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions DOI
Ziyi Han,

Jingdi Xiong,

Xiaohan Jin

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(4), P. 842 - 871

Published: Dec. 5, 2023

Infectious bone defects are characterized by the partial loss or destruction of tissue resulting from bacterial contaminations subsequent to diseases external injuries. Traditional transplantation and clinical methods insufficient in meeting treatment demands for such diseases. As a result, researchers have increasingly focused on development more sophisticated biomaterials improved therapeutic outcomes recent years. This review endeavors investigate specific reparative materials utilized infectious defects, particularly those present maxillofacial region, with focus capable releasing substances, functional contact biomaterials, novel physical therapy materials. These operate

Language: Английский

Toward bioactive calcium carbonate and hydroxyapatite-based coatings via plasma electrolytic oxidation – A review of challenges and current state-of-the-art DOI

Vladlens Grebņevs,

Artūrs Vīksna, Wojciech Simka

et al.

Surface and Coatings Technology, Journal Year: 2025, Volume and Issue: 506, P. 132135 - 132135

Published: April 10, 2025

Language: Английский

Citations

0
Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery DOI Creative Commons
Shuangshuang Zhang, Fei Liu, Song Xiang

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113992 - 113992

Published: April 1, 2025

Language: Английский

Citations

0
Biomaterial engineering surface to control polymicrobial dental implant-related infections: focusing on disease modulating factors and coatings development DOI
Samuel Santana Malheiros, B Nagay, Martinna Bertolini

et al.

Expert Review of Medical Devices, Journal Year: 2023, Volume and Issue: 20(7), P. 557 - 573

Published: May 25, 2023

Peri-implantitis is the leading cause of dental implant loss and initiated by a polymicrobial dysbiotic biofilm formation on surface. The destruction peri-implant tissue host immune response low effectiveness surgical or non-surgical treatments highlight need for new strategies to prevent, modulate and/or eliminate Currently, several surface modifications have been proposed using biomolecules, ions, antimicrobial agents, topography alterations.Initially, this review provides an overview etiopathogenesis host- material-dependent modulating factors disease. In addition, critical discussion about modification mechanisms techniques employed modify titanium material provided. Finally, we also considered future perspectives development surfaces narrow bridge between idea product favor clinical application possibility.Antimicrobial demonstrated effective results; however, there no consensus best strategy in-depth information safety longevity effect. Modified display recurring challenges such as short-term effectiveness, burst release drugs, cytotoxicity, lack reusability. Stimulus-responsive seem be promising controlled precise effect, research should focus technology study it from models that better mimic conditions.

Language: Английский

Citations

9
A Dual‐Antioxidative Coating on Transmucosal Component of Implant to Repair Connective Tissue Barrier for Treatment of Peri‐Implantitis DOI Open Access
Dize Li,

Xi Tan,

Liwen Zheng

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(30)

Published: Sept. 3, 2023

Since the microgap between implant and surrounding connective tissue creates pass for pathogen invasion, sustained pathological stimuli can accelerate macrophage-mediated inflammation, therefore affecting peri-implant regeneration aggravate peri-implantitis. As transmucosal component of implant, abutment needs to be biofunctionalized repair gingival barrier. Here, a mussel-bioinspired coating containing tannic acid (TA), cerium minocycline (TA-Ce-Mino) is reported. TA provides pyrogallol catechol groups promote cell adherence. Besides, Ce3+ /Ce4+ conversion exhibits enzyme-mimetic activity remove reactive oxygen species while generating O2 , promoting anti-inflammatory M2 macrophage polarization help create regenerative environment. Minocycline involved on surface local drug storage responsive antibiosis. Moreover, underlying therapeutic mechanism revealed whereby exogenous antioxidation from inherent properties Ce endogenous through mitochondrial homeostasis maintenance antioxidases promotion. In addition, it stimulates integrin activate PI3K/Akt RhoA/ROCK pathways enhance VEGF-mediated angiogenesis regeneration. Combining antibiosis multidimensional orchestration, TA-Ce-Mino repairs soft barriers effector differentiation, thereby isolating immune microenvironment invasion. Consequently, this study critical insight into design biological modification prevent

Language: Английский

Citations

9
Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions DOI
Ziyi Han,

Jingdi Xiong,

Xiaohan Jin

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(4), P. 842 - 871

Published: Dec. 5, 2023

Infectious bone defects are characterized by the partial loss or destruction of tissue resulting from bacterial contaminations subsequent to diseases external injuries. Traditional transplantation and clinical methods insufficient in meeting treatment demands for such diseases. As a result, researchers have increasingly focused on development more sophisticated biomaterials improved therapeutic outcomes recent years. This review endeavors investigate specific reparative materials utilized infectious defects, particularly those present maxillofacial region, with focus capable releasing substances, functional contact biomaterials, novel physical therapy materials. These operate

Language: Английский

Citations

9