Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 465, P. 133189 - 133189
Published: Dec. 6, 2023
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 17852 - 17868
Published: June 28, 2024
The discovery of cuproptosis, a copper-dependent mechanism programmed cell death, has provided way for cancer treatment. However, cuproptosis inherent limitations, including potential cellular harm, the lack targeting, and insufficient efficacy as standalone Therefore, exogenously controlled combination treatments have emerged key strategies cuproptosis-based oncotherapy. In this study, Cu2–xSe@cMOF nanoplatform was constructed combined sonodynamic/cuproptosis/gas therapy. This platform enabled precise cotreatment, with external control allowing selective induction in cells. approach effectively prevented metastasis recurrence. Furthermore, antiprogrammed death protein ligand-1 antibody (aPD-L1), maximized advantages immune checkpoint Additionally, under ultrasound irradiation, H2Se gas generated from induced cytotoxicity Further, it reactive oxygen species, which hindered survival proliferation. study reports an externally system that combines carbonized metal–organic framework aPD-L1 to enhance precision reinforced therapy could be valuable effective therapeutic agent reduce mortality morbidity future.
Language: Английский
Citations
62
Process Safety and Environmental Protection, Journal Year: 2024, Volume and Issue: 208, P. 391 - 435
Published: June 28, 2024
Language: Английский
Citations
19
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 331, P. 103210 - 103210
Published: June 5, 2024
Language: Английский
Citations
18
RSC Advances, Journal Year: 2024, Volume and Issue: 14(41), P. 30201 - 30229
Published: Jan. 1, 2024
Recently, metal-organic frameworks (MOFs) have attracted much attention as versatile materials for drug delivery and personalized medicine. MOFs are porous structures made up of metal ions coupled with organic ligands. This review highlights the synthesis techniques used to design specific features such surface area pore size, encapsulation within not only improves their stability solubility but also allows controlled release kinetics, which therapeutic efficacy minimizes adverse effects. Furthermore, it discusses challenges potential advantages MOF-based delivery, MOF stability, biocompatibility, scale-up production. With further advancements in synthesis, functionalization techniques, understanding interactions using biological systems, can significant promise expanding medicine improving patient outcomes.
Language: Английский
Citations
18
Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 76, P. 101122 - 101122
Published: July 27, 2024
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Language: Английский
Citations
14
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160373 - 160373
Published: Feb. 1, 2025
Language: Английский
Citations
1
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2021 - 2041
Published: Feb. 1, 2025
DNA-based functional nanomaterials are distinguished by their structural designability and controllability, making them particularly attractive in the biomedical field. Using DNA for cancer treatment through synergistic approaches combining photodynamic therapy photothermal has garnered significant attention. This growing interest driven active development of various tailored integrated strategies targeting cancer, including phototherapy, chemotherapy, etc. review provides an overview nanoplatforms employed phototherapy treatment. It highlights recent advances that leverage multifaceted synergy to enhance phototherapeutic efficacy. also offers a new perspectives clinical application potential malignant tumors, focusing on developments years directions future research applications.
Language: Английский
Citations
1
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 679, P. 214 - 223
Published: Sept. 29, 2024
Language: Английский
Citations
7
Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 102, P. 114155 - 114155
Published: Oct. 19, 2024
Language: Английский
Citations
6
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 9, 2024
The field of oncology has transformed in recent years, with treatments shifting from traditional surgical resection and radiation therapy to more diverse customized approaches, one which is immunotherapy. ICD (immunogenic cell death) belongs a class regulatory death modalities that reactivate the immune response by facilitating interaction between apoptotic cells releasing specific signaling molecules, DAMPs (damage-associated molecular patterns). inducers can elevate expression proteins optimize TME (tumor microenvironment). use nanotechnology shown its unique potential. Nanomaterials, due their tunability, targeting, biocompatibility, have become powerful tools for drug delivery, immunomodulators, etc., significant efficacy clinical trials. In particular, these nanomaterials effectively activate ICD, trigger potent anti-tumor response, maintain long-term tumor suppression. Different types nanomaterials, such as biological membrane-modified nanoparticles, self-assembled nanostructures, metallic mesoporous materials, hydrogels, play respective roles induction structures mechanisms action. Therefore, this review will explore latest advances application common discuss how they provide new strategies cancer therapy. By gaining deeper understanding mechanism action researchers develop precise effective therapeutic approaches improve prognosis quality life patients. Moreover, hold promise overcome resistance conventional therapies, minimize side effects, lead personalized treatment regimens, ultimately benefiting treatment.
Language: Английский
Citations
5