Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Abstract
Nature
enzymes
always
suffer
from
high
costs,
harsh
conditions,
and
instability,
while,
artificial
one
offers
possibilities
for
addressing
current
challenges
plays
a
significant
role
in
future
industrial
production.
Here,
the
carbon
dots
(CDs),
with
well‐defined
polycyclic
dipeptide
structures,
are
reported
to
exhibit
superior
hydrolase‐like
catalytic
performance
beyond
those
of
natural
enzymes.
Compared
lipase,
obtained
CDs
not
only
activity
(2.85
times
increase
V
m
)
but
also
have
broader
range
substrate
concentrations
(0–8.0
types
(fatty
ester,
aromatic
phosphate
ester),
along
simpler
conditions
stability.
The
highly
efficient
is
attributed
low
activation
energy
reaction
(E
:
13.74
kJ
mol
−1
strong
adsorption
substrates.
results
theoretical
calculations
comparative
experiments
demonstrate
that
sites
located
on
nitrogen
atoms
dipeptide.
Furthermore,
membrane
integrated
(membrane‐catalyst)
constructed,
through
which
instantaneous
hydrolysis
esters
can
be
realized.
This
work
provides
new
insight
into
enzyme‐like
mechanisms
approach
designing
materials
performance.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2229 - 2243
Published: Jan. 1, 2024
Nanozymes,
a
distinctive
class
of
nanomaterials
with
enzyme-like
activity
and
kinetics
akin
to
enzyme-catalysed
reactions,
present
several
advantages
over
natural
enzymes,
including
cost-effectiveness,
heightened
stability,
adjustable
activity.
Organophosphorus
pesticides
(OPs)
pose
significant
environmental
and
health
risks,
their
detoxification
through
catalytic
hydrolysis
using
zirconium-based
metal–organic
frameworks
(Zr-MOFs)
has
attracted
considerable
interest
due
to
the
strong
Lewis
acid
metal
ions.
Albeit
important,
defects
of
materials
for
OP
(e.g.,
poor
degradation
efficiency,
rate,
selectivity)
limit
further
application.
Herein,
a
nucleic
bionic
arm-modified
biomimetic
nanozyme
(MOF-808-Apt)
was
designed
Zr-MOF
specific
aptamer
against
OPs,
which
employed
efficient
selective
OPs.
At
system,
functionalized
can
continuously
capture
trace
OPs
onto
its
sites
with
fabricated
arms,
significantly
improving
activities
compared
bare
MOF-808
paraoxon
as
model
providing
better
performances
including
(i)
an
excellent
boosting
from
4
over
60%
within
6
min;
(ii)
satisfactory
rate
(the
pseudo-first-order
constants
improved
0.09
0.14
min–1);
(iii)
good
because
aptamers
used.
Besides,
this
dynamic
process
could
be
visually
recorded
in
real
time
high
sensitivity
(limit
detection,
0.18
μM)
obvious
color
change
reaction
solution
signal
amplification
ascribed
increasing
local
concentrations
targets
by
arms.
Summarily,
work
provides
new
strategy
effective
typical
concurrent
monitoring
process.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Organophosphorus
pesticides
(OPs)
are
widely
used
in
agricultural
production,
posing
a
great
threat
to
human
health
and
the
environment.
Given
that
different
OPs
present
toxicology
toxicities,
identifying
individual
pesticide
residues
becomes
important
for
assessing
food
safety
environmental
implications.
In
this
work,
kinetics
difference-driven
analyte
hydrolysis
strategy
is
proposed
first
time
validated
identify
p-nitrophenyl
by
developing
an
organophosphorus
hydrolase-like
nanozyme-coded
sensor
array.
Ultrasmall
bare
CeO2
nanoparticles
were
synthesized
employed
as
only
sensing
unit
catalyze
of
multiple
analytes.
With
catalytic
preferences
differences
under
identical
reaction
conditions,
five
common
analogues
(methyl-paraoxon,
paraoxon,
methyl-parathion,
parathion,
fenitrothion)
offered
discriminable
colors.
By
coupling
color
fingerprints
with
pattern
recognition,
accurate
identification
their
mixtures
at
variety
concentrations
ratios
was
verified
laboratory
practical
scenarios.
Attractively,
apart
from
excellent
performance
convenient
operation,
hydrolytic
presents
strong
resistance
against
redox
substances
often
cause
interference
previous
oxidoreductase-based
arrays.
Our
study
provides
new
paradigm
discriminating
specific
precisely,
showing
promising
applications
multitarget
analysis
complex
matrices.
The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Abstract
Biomolecule‐engineered
metal‐organic
frameworks
(Bio‐MOFs)
are
designed
by
incorporating
biomolecules
into
or
onto
MOFs
through
covalent
and
non‐covalent
interactions.
These
composite
exhibit
unique
catalytic
biological
activities,
making
them
highly
suitable
for
various
biocatalytic
applications.
In
this
review,
we
highlight
recent
advances
in
the
material
design,
bioengineering
methods,
structural
functional
regulation
techniques,
applications
of
Bio‐MOFs.
From
a
materials
perspective,
explore
their
structures
multifunctional
properties,
including
high
surface
area,
tunable
pore
sizes,
excellent
biocompatibility.
We
also
discuss
techniques
such
as
biomineralization
post‐synthetic
modification
that
employed
synthesis.
Furthermore,
examine
regulations
Bio‐MOFs,
which
enhance
activity
stability
interactions
with
enzymes,
peptides,
other
biomolecules.
Finally,
analyze
diverse
reactions,
biosensors/sensors,
drug
delivery,
therapy,
organic
wastewater
purification,
emerging
bio‐energy
science.
This
review
underscores
pivotal
role
enhancing
functions
aims
to
inspire
design
synthesis
novel
Bio‐MOFs
future
bio‐related
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Abstract
Oral
diseases
rank
among
the
most
prevalent
clinical
conditions
globally,
typically
involving
detrimental
factors
such
as
infection,
inflammation,
and
injury
in
their
occurrence,
development,
outcomes.
The
concentration
of
reactive
oxygen
species
(ROS)
within
cells
has
been
demonstrated
a
pivotal
player
modulating
these
intricate
pathological
processes,
exerting
significant
roles
restoring
oral
functionality
maintaining
tissue
structural
integrity.
Due
to
enzyme‐like
catalytic
properties,
unique
composition,
intelligent
design,
ROS‐based
nanomaterials
have
garnered
considerable
attention
nanomedicine.
Such
capacity
influence
spatiotemporal
dynamics
ROS
biological
systems,
guiding
evolution
intra‐ROS
facilitate
therapeutic
interventions.
This
paper
reviews
latest
advancements
functional
customization,
medical
applications
nanomaterials.
Through
analysis
components
designs
various
novel
nanozymes
nanoplatforms
responsive
different
stimuli
dimensions,
it
elaborates
on
impacts
dynamic
behavior
potential
regulatory
mechanisms
body.
Furthermore,
discusses
prospects
strategies
nanotherapies
based
scavenging
generation
diseases,
offering
alternative
insights
for
design
development
treating
ROS‐related
conditions.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Marine
pollution
poses
a
serious
threat
to
the
ecological
environment,
destroys
habitats,
reduces
biodiversity,
and
negatively
impacts
fisheries
human
health.
Therefore,
development
of
efficient
marine
antifouling
strategies
is
great
significance.
This
study
introduces
manganese
selenide
nanoflowers
(MnSe
NFs)
as
multifamily
nanozymes,
exhibiting
phosphoesterase-,
oxidase-,
peroxidase-like
activities.
The
catalytic
mechanism
this
nanozyme
was
elucidated
using
density
functional
theory
calculations
spectroscopic
analyses.
Laboratory
tests
demonstrated
that
MnSe
NFs
exhibit
strong
efficacy
against
biofilms
formed
by
Staphylococcus
aureus
Pseudomonas
aeruginosa,
achieving
an
antibacterial
rate
exceeding
99.999%.
In
scenarios,
ship
hulls
coated
with
NF-based
paints
significantly
inhibited
biofilm
formation
for
over
90
days,
offering
advantages
in
environmental
friendliness,
sustainability,
cost-effectiveness.
provides
novel
approach
controlling
highlights
potential
nanozymes
sustainable
eco-friendly
solution
technologies.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
Abstract
With
the
rapid
development
of
nanozymes
and
nanomedicine,
designing
novel
nanostructures
directly
acting
on
deoxyribonucleic
acid
(DNA)
has
great
therapeutic
potential
because
DNA
is
carrier
genetic
information
plays
a
vital
role
life
activities
organism.
Specifically,
cleavage
an
important
step
in
most
these
engineering
technologies.
While
nucleases
play
crucial
roles
cell
metabolism
by
efficient
cutting,
practical
applications
natural
suffer
from
some
intrinsic
shortcomings
such
as
high
cost
intolerance
to
harsh
environments.
In
past
20
years,
varieties
engineered
with
(nuclease‐mimetic
nanomaterials,
abbreviated
nuclease
mimics)
have
been
developed
rapidly
widely
used
biomedical
fields.
view
significant
progress
nuclease‐mimetic
possible
mechanism
mediated
nanomaterials
systematically
discussed
this
review,
classification
illustrated.
Their
applications,
especially
anti‐biofilms
cancer
treatment,
are
also
comprehensively
summarized.
Finally,
current
opportunities
challenges
stimulate
research
understanding
nanomaterials.
