Optimization analysis of the particle focusing and separation parameters of a sheathless microfluidic device using standing surface acoustic waves DOI
Min‐Haw Wang, Yi-Chen Lee, Ting‐Yuan Tu

et al.

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(11)

Published: Nov. 1, 2024

Flow-based particle separation usually requires a sheath flow for manipulation. Sheath fluid is specialized buffer solution that directs the alignment of particles or cells into center stream. By utilizing flow, can be focused on middle line microchannel, where they individually analyzed. However, method an additional design creating suitable flow. Purity and efficiency may also influenced by In this study, we present sheathless device focusing using standing surface acoustic waves (SSAWs). The comprises two regions: regions. region, in continuous are aligned microchannel SSAWs; tilted-angle SSAW-based used to control migration. Varying sizes were region then separated device. Experiments simulations utilized optimize 10 20 μm conducted first time. We demonstrate with diameter has 90.8 ± 1.75% 99.5 0.8% efficiency, 98 3.4 97.9 0.9% purity. Compared other technologies, our provide high purity, density.

Language: Английский

Design and Numerical Simulation of a Standing Surface Acoustic Wave-Based Microdevice for Whole Blood Cell Separation DOI Creative Commons

Maryam Hajimoradi,

Moein Talebian Gevari, Keith Pullen

et al.

Computation, Journal Year: 2025, Volume and Issue: 13(2), P. 42 - 42

Published: Feb. 6, 2025

Standing surface acoustic wave (SSAW)-based acoustofluidics is widely used due to its compatibility with soft materials and polymer structures. In the presence of an field, particles move either toward pressure nodes or anti-nodes according their contrast factor. Using this technique, blood cells a certain characteristic can be oriented in different streamlines microchannel. The cumulative effect parameters, such as inlet velocity ratio buffer solution sample, frequency, voltage, channel geometry, key effective separation these microfluidic chips. study, simultaneous white cells, red platelets one stage simulated by means numerical calculations. linear constitutive equation for piezoelectric substrate, Helmholtz Navier–Stokes equations fluid mechanics are solved simultaneously precisely capture cell behavior SSAW-based device. results show that whole achieved using 6.25, resonance frequency 8.28 MHz, voltage 8.5 V proposed five-outlet chip.

Language: Английский

Citations

0
Microfluidic-assisted engineering of hydrogels with microscale complexity DOI
Yuehong Li,

Danyang Huang,

Yuting Zhang

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Microfluidic Device for Both Active and Passive Cell Separation Techniques: A Review DOI Creative Commons
Muhammad Asraf Mansor, Muhammad Asyraf Jamrus,

Chong Kar Lok

et al.

Sensors and Actuators Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100277 - 100277

Published: Dec. 1, 2024

Language: Английский

Citations

2
Optimization analysis of the particle focusing and separation parameters of a sheathless microfluidic device using standing surface acoustic waves DOI
Min‐Haw Wang, Yi-Chen Lee, Ting‐Yuan Tu

et al.

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(11)

Published: Nov. 1, 2024

Flow-based particle separation usually requires a sheath flow for manipulation. Sheath fluid is specialized buffer solution that directs the alignment of particles or cells into center stream. By utilizing flow, can be focused on middle line microchannel, where they individually analyzed. However, method an additional design creating suitable flow. Purity and efficiency may also influenced by In this study, we present sheathless device focusing using standing surface acoustic waves (SSAWs). The comprises two regions: regions. region, in continuous are aligned microchannel SSAWs; tilted-angle SSAW-based used to control migration. Varying sizes were region then separated device. Experiments simulations utilized optimize 10 20 μm conducted first time. We demonstrate with diameter has 90.8 ± 1.75% 99.5 0.8% efficiency, 98 3.4 97.9 0.9% purity. Compared other technologies, our provide high purity, density.

Language: Английский

Citations

1