The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: 128(46), P. 11481 - 11491

Published: Nov. 6, 2024

Liposomes, which encapsulate drugs into an inner aqueous core and demonstrate high drug-loading capacity, have attracted considerable interest in the field of drug delivery. Herein, encapsulation processes for amphiphilic copolymers within liposomes been investigated systematically to enhance capacity optimize structures using dissipative particle dynamics simulations. The results indicate that physicochemical properties lipids, receptors, collectively determine behaviors liposomes. Adjusting hydrophobic interaction between tails lipids (receptors) blocks copolymers, along with modulating specific ligands functional head groups can lead various capacities. Significantly, a medium strength or strong is conducive achieving higher degree copolymers. Furthermore, varying key parameters, such as interaction, well concentrations induce seven typical aggregate structures: heterogeneous, fully encapsulated, partially saturated-encapsulated, unsaturated-encapsulated, multilamellar, column-like structures. final phase diagrams are also constructed provide guideline designing encapsulated These significantly contribute illumination strategies rational construction self-assembly system facilitates efficient liposomes, thereby providing valuable insights optimal design liposome carriers future biomedical applications.

Language: Английский