The Functional and Imaging Implications of Left Bundle Branch Pacing in Ischemic Cardiomyopathy DOI Creative Commons
Fulvio Cacciapuoti, Ciro Mauro,

Ilaria Caso

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 489 - 489

Published: March 26, 2025

Heart failure with reduced ejection fraction due to ischemic cardiomyopathy remains a significant clinical challenge. Electrical conduction delays exacerbate symptoms by causing uncoordinated contractions, reducing pumping efficiency, and increasing mortality. Right ventricular pacing further worsens dyssynchrony, while resynchronization therapy improves outcomes but has high non-responder rate. Given these limitations, bundle branch engages the heart's system, restoring synchronized contraction enhancing cardiac function. This review examines impact of left-bundle-branch-block-induced role advanced imaging in assessing function, heart patients. Specifically, we explore mechanical hemodynamic effects left block, techniques for dyssynchrony evaluation, comparative benefits versus therapy. Conduction impair increase myocardial stress, worsen outcomes. Advanced plays critical patient selection, identifying those most likely benefit from system pacing. By electrical coordination, enhances reduces hospitalizations, promotes reverse remodeling. It offers similar or superior conventional therapy, regulates stress hormones, oxidative damage, calcium handling. Bundle represents advancement management, careful selection crucial. Future research should focus on optimizing implantation validating long-term through large-scale trials.

Language: Английский

Association of neutrophil to high density lipoprotein cholesterol ratio with aortic dissection and aneurysm risk: epidemiological insights from prospective cohort study based on UK biobank DOI Creative Commons
Cuihong Tian, Xiao Wang, Liang Tao

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 6, 2025

Neutrophil to high-density lipoprotein cholesterol ratio (NHR) is a metabolic inflammatory biomarker reflecting the balance between pro- and anti-inflammatory responses. Extensive research has revealed that NHR an effective predictor for cardiovascular risks, such as stroke myocardial infarction. Nevertheless, association incidence risks of aortic dissection (AD) aneurysm (AA) remains unclear. This research, designed prospective cohort study, enrolled 409,357 participants based on UK Biobank project. The cut-off value i.e., 0.205, was determined using receiver operating characteristic curve grouping. Participants were divided into two groups: ≤ 0.205 (n = 293,294) > 116,063). cumulative outcome, AD/AA including AD AA, calculated Kaplan-Meier curves. dose-response relationship evaluated restricted cubic spline (RCS). Multivariable-adjusted Cox proportional hazards regression models, followed by sensitivity analyses subgroup analyses, performed evaluate onset. A total 3,408 developed AD/AA, 233 cases 3,259 AA cases, with median follow-up period 14.8 years. incidences 56.34, 3.85 53.87 per 100,000 person-years, respectively. nonlinear risk documented RCS (P < 0.001). in group had higher developing compared those group, adjusted HR 1.47 (95%CI 1.37-1.58). further validated analyses. independent factor AD/AA. disorder inflammation may be potential pathological mechanism Tailored assessment management serve strategies prevention prediction

Language: Английский

Citations

0

The Functional and Imaging Implications of Left Bundle Branch Pacing in Ischemic Cardiomyopathy DOI Creative Commons
Fulvio Cacciapuoti, Ciro Mauro,

Ilaria Caso

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 489 - 489

Published: March 26, 2025

Heart failure with reduced ejection fraction due to ischemic cardiomyopathy remains a significant clinical challenge. Electrical conduction delays exacerbate symptoms by causing uncoordinated contractions, reducing pumping efficiency, and increasing mortality. Right ventricular pacing further worsens dyssynchrony, while resynchronization therapy improves outcomes but has high non-responder rate. Given these limitations, bundle branch engages the heart's system, restoring synchronized contraction enhancing cardiac function. This review examines impact of left-bundle-branch-block-induced role advanced imaging in assessing function, heart patients. Specifically, we explore mechanical hemodynamic effects left block, techniques for dyssynchrony evaluation, comparative benefits versus therapy. Conduction impair increase myocardial stress, worsen outcomes. Advanced plays critical patient selection, identifying those most likely benefit from system pacing. By electrical coordination, enhances reduces hospitalizations, promotes reverse remodeling. It offers similar or superior conventional therapy, regulates stress hormones, oxidative damage, calcium handling. Bundle represents advancement management, careful selection crucial. Future research should focus on optimizing implantation validating long-term through large-scale trials.

Language: Английский

Citations

0