Association of neutrophil to high density lipoprotein cholesterol ratio with aortic dissection and aneurysm risk: epidemiological insights from prospective cohort study based on UK biobank
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 6, 2025
Neutrophil
to
high-density
lipoprotein
cholesterol
ratio
(NHR)
is
a
metabolic
inflammatory
biomarker
reflecting
the
balance
between
pro-
and
anti-inflammatory
responses.
Extensive
research
has
revealed
that
NHR
an
effective
predictor
for
cardiovascular
risks,
such
as
stroke
myocardial
infarction.
Nevertheless,
association
incidence
risks
of
aortic
dissection
(AD)
aneurysm
(AA)
remains
unclear.
This
research,
designed
prospective
cohort
study,
enrolled
409,357
participants
based
on
UK
Biobank
project.
The
cut-off
value
i.e.,
0.205,
was
determined
using
receiver
operating
characteristic
curve
grouping.
Participants
were
divided
into
two
groups:
≤
0.205
(n
=
293,294)
>
116,063).
cumulative
outcome,
AD/AA
including
AD
AA,
calculated
Kaplan-Meier
curves.
dose-response
relationship
evaluated
restricted
cubic
spline
(RCS).
Multivariable-adjusted
Cox
proportional
hazards
regression
models,
followed
by
sensitivity
analyses
subgroup
analyses,
performed
evaluate
onset.
A
total
3,408
developed
AD/AA,
233
cases
3,259
AA
cases,
with
median
follow-up
period
14.8
years.
incidences
56.34,
3.85
53.87
per
100,000
person-years,
respectively.
nonlinear
risk
documented
RCS
(P
<
0.001).
in
group
had
higher
developing
compared
those
group,
adjusted
HR
1.47
(95%CI
1.37-1.58).
further
validated
analyses.
independent
factor
AD/AA.
disorder
inflammation
may
be
potential
pathological
mechanism
Tailored
assessment
management
serve
strategies
prevention
prediction
Language: Английский
The Functional and Imaging Implications of Left Bundle Branch Pacing in Ischemic Cardiomyopathy
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 489 - 489
Published: March 26, 2025
Heart
failure
with
reduced
ejection
fraction
due
to
ischemic
cardiomyopathy
remains
a
significant
clinical
challenge.
Electrical
conduction
delays
exacerbate
symptoms
by
causing
uncoordinated
contractions,
reducing
pumping
efficiency,
and
increasing
mortality.
Right
ventricular
pacing
further
worsens
dyssynchrony,
while
resynchronization
therapy
improves
outcomes
but
has
high
non-responder
rate.
Given
these
limitations,
bundle
branch
engages
the
heart's
system,
restoring
synchronized
contraction
enhancing
cardiac
function.
This
review
examines
impact
of
left-bundle-branch-block-induced
role
advanced
imaging
in
assessing
function,
heart
patients.
Specifically,
we
explore
mechanical
hemodynamic
effects
left
block,
techniques
for
dyssynchrony
evaluation,
comparative
benefits
versus
therapy.
Conduction
impair
increase
myocardial
stress,
worsen
outcomes.
Advanced
plays
critical
patient
selection,
identifying
those
most
likely
benefit
from
system
pacing.
By
electrical
coordination,
enhances
reduces
hospitalizations,
promotes
reverse
remodeling.
It
offers
similar
or
superior
conventional
therapy,
regulates
stress
hormones,
oxidative
damage,
calcium
handling.
Bundle
represents
advancement
management,
careful
selection
crucial.
Future
research
should
focus
on
optimizing
implantation
validating
long-term
through
large-scale
trials.
Language: Английский