The role of neutrophil extracellular traps in inflammatory rheumatic diseases DOI
Norio Hanata, Mariana J. Kaplan

Current Opinion in Rheumatology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Purpose of review Dysregulation in neutrophil extracellular trap (NET) formation and degradation has been reported several inflammatory rheumatic diseases. This summarizes the recent advances understanding role NETs context Recent findings NET is enhanced peripheral blood patients with large vessel vasculitis polymyalgia rheumatica. are detected affected organs autoimmune conditions, they might play pathological roles tissues. Several understudied medications supplements suppress ameliorate animal models anti-NET antibodies have potential utility as disease biomarkers. Summary Growing evidence suggested contribution dysregulation to pathogenesis Further research warranted regard clinical impact modulating aberrant clearance

Language: Английский

Lupus Nephritis from Pathogenesis to New Therapies: An Update DOI Open Access
Annalisa Roveta, E Parodi,

Brigida Brezzi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8981 - 8981

Published: Aug. 18, 2024

Lupus Nephritis (LN) still represents one of the most severe complications Systemic Erythematosus (SLE) and a major risk factor for morbidity mortality. However, over last few years, several studies have paved way deeper understanding its pathogenetic mechanisms more targeted treatments. This review aims to provide comprehensive update on progress key aspects in this setting: LN, including new insight into role autoantibodies, complement, vitamin D deficiency, interaction between infiltrating immune cells kidney resident ones; evolving renal biopsy biomarkers, which may integrate information from histology; newly approved drugs such as voclosporin (VOC) belimumab (BEL), allowing articulate strategy induction therapy, other promising phase III-immunosuppressive (IS) agents pipeline. Several adjunctive treatments aimed at reducing cardiovascular progression chronic damage, antiproteinuric agents, represent an important complement IS therapy. Furthermore, non-pharmacological measures concerning general lifestyle diet should also be adopted when managing LN. Integrating these therapeutic areas requires effort towards holistic multidisciplinary approach. At same time, availability increasingly wider armamentarium translate improvements patient’s outcomes next decades.

Language: Английский

Citations

6
Indoxyl sulfate (IS) mediates pro-inflammatory responses in severe pneumonia in patients with rheumatoid arthritis associated interstitial lung disease DOI
Minghua Zhan, Ziyao Li, Jianing Chen

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110430 - 110430

Published: Jan. 1, 2025

Language: Английский

Citations

0
Characterization of anti-neutrophil extracellular traps (NET) antibodies according to systemic lupus erythematosus clinical phenotypes DOI
Daniel Alberto Carrillo-Vázquez,

Jennifer Balderas-Miranda,

R. Rivera

et al.

Immunologic Research, Journal Year: 2025, Volume and Issue: 73(1)

Published: May 9, 2025

Language: Английский

Citations

0
A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases DOI Open Access
Yanhong Li, Yinlan Wu, Jingang Huang

et al.

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 280 - 299

Published: Oct. 18, 2023

Neutrophils are important in the context of innate immunity and actively contribute to progression diverse autoimmune disorders. Distinct death mechanisms neutrophils may exhibit specific pivotal roles diseases disease pathogenesis through orchestration immune homeostasis, facilitation autoantibody production, induction tissue organ damage, incitement pathological alterations. In recent years, more studies have provided in-depth examination various neutrophil modes, revealing nuances that challenge conventional understanding underscoring their potential clinical utility diagnosis treatment. This review explores multifaceted processes characteristics death, with a focus on tailored investigations within diseases. It also highlights interplay between landscape The encapsulates pertinent pathways implicated across while charts possible avenues for future research.

Language: Английский

Citations

9
An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus DOI Open Access
Tetsuo Kubota

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16499 - 16499

Published: Nov. 19, 2023

Anti-DNA antibodies are hallmark autoantibodies produced in systemic lupus erythematosus (SLE), but their pathogenetic role is not fully understood. Accumulating evidence suggests that some anti-DNA enter different types of live cells and affect the pathophysiology SLE by stimulating or impairing these cells. Circulating neutrophils activated a type I interferon other stimuli primed to release neutrophil extracellular traps (NETs) on additional stimulation. also involved this process may induce NET release. Thereafter, they bind protect DNA NETs from digestion nucleases, resulting increased immunogenicity. This review discusses SLE, mainly focusing recent progress two research fields concerning antibody penetration into NETosis.

Language: Английский

Citations

4
Recent advances on neutrophil dysregulation in the pathogenesis of rheumatic diseases DOI
Jianing Chen, Xinyu Wang, Yudong Liu

et al.

Current Opinion in Rheumatology, Journal Year: 2023, Volume and Issue: 36(2), P. 142 - 147

Published: Nov. 1, 2023

Purpose of review The exact pathogenic mechanisms rheumatic diseases (RMD) remain largely unknown. Increasing evidence highlights a role neutrophil dysregulation in the development RMD. Recent findings purpose this is to present current overview recent advancements understanding dysfunction Additionally, will discuss strategies for targeting pathways associated with as potential treatments One specific aspect dysregulation, known extracellular traps (NETs), be explored. NETs have been found contribute chronic pulmonary inflammation and fibrosis, well serve DNA scaffolds binding autoantigens, including both citrullinated carbamylated autoantigens. Putative therapies, such 6-gingerol or defibrotide, demonstrated beneficial effects treatment RMD by suppressing formation. Summary advances significantly reinforced crucial pathogenesis A deeper underlying process would aid more precise effective strategies, thus ultimately improving outcomes

Language: Английский

Citations

3
The role of neutrophil extracellular traps in inflammatory rheumatic diseases DOI
Norio Hanata, Mariana J. Kaplan

Current Opinion in Rheumatology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Purpose of review Dysregulation in neutrophil extracellular trap (NET) formation and degradation has been reported several inflammatory rheumatic diseases. This summarizes the recent advances understanding role NETs context Recent findings NET is enhanced peripheral blood patients with large vessel vasculitis polymyalgia rheumatica. are detected affected organs autoimmune conditions, they might play pathological roles tissues. Several understudied medications supplements suppress ameliorate animal models anti-NET antibodies have potential utility as disease biomarkers. Summary Growing evidence suggested contribution dysregulation to pathogenesis Further research warranted regard clinical impact modulating aberrant clearance

Language: Английский

Citations

0