Endocrine dysregulation in COVID-19: molecular mechanisms and insights DOI Creative Commons
Cristiana Iosef,

Andrei M. Matusa,

Victor K. M. Han

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 22, 2024

This review describes the impact of COVID-19 on endocrine system, focusing cortisol signaling and growth factor-induced resistance. As expected, SARS-CoV-2 infection induces systemic inflammation, resulting in stimulation adrenal glands leading to elevated levels with normal adrenocorticotropic hormone (ACTH) levels. The cytokine storm could also stimulate production. However, some instances, rise independently ACTH due a phenomenon known as “pseudo-Cushing’s syndrome,” where become less responsive ACTH. Plasma proteomic analyses showed that this pattern was variably observed among patients, potentially involving calcium dysregulation GNAS-regulated activities, ultimately impacting regulation microvascular permeability. exhibited syndrome resembling resistance, governed by receptor tyrosine kinase pathways. Mild cases displayed activity EGFR MMP9, along increased expression survival factors like Bax Bcl2. In contrast, more severe involved IGFR-I enhanced NOTCH signaling, altered Bcl2, AKT1, MAPK8. summary, these findings describe complex interplay between pathology, particularly These insights suggest potential targets for therapeutic interventions improve short- long-term outcomes patients.

Language: Английский

Increased Risk of Thyroid Eye Disease Following Covid-19 Vaccination DOI Creative Commons
Ilaria Muller, Dario Consonni, Erica Crivicich

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(2), P. 516 - 526

Published: Aug. 23, 2023

SARS-CoV-2 infection and Covid-19 vaccines have been associated with thyroid disorders.

Language: Английский

Citations

14
Endocrine dysregulation in COVID-19: molecular mechanisms and insights DOI Creative Commons
Cristiana Iosef,

Andrei M. Matusa,

Victor K. M. Han

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 22, 2024

This review describes the impact of COVID-19 on endocrine system, focusing cortisol signaling and growth factor-induced resistance. As expected, SARS-CoV-2 infection induces systemic inflammation, resulting in stimulation adrenal glands leading to elevated levels with normal adrenocorticotropic hormone (ACTH) levels. The cytokine storm could also stimulate production. However, some instances, rise independently ACTH due a phenomenon known as “pseudo-Cushing’s syndrome,” where become less responsive ACTH. Plasma proteomic analyses showed that this pattern was variably observed among patients, potentially involving calcium dysregulation GNAS-regulated activities, ultimately impacting regulation microvascular permeability. exhibited syndrome resembling resistance, governed by receptor tyrosine kinase pathways. Mild cases displayed activity EGFR MMP9, along increased expression survival factors like Bax Bcl2. In contrast, more severe involved IGFR-I enhanced NOTCH signaling, altered Bcl2, AKT1, MAPK8. summary, these findings describe complex interplay between pathology, particularly These insights suggest potential targets for therapeutic interventions improve short- long-term outcomes patients.

Language: Английский

Citations

0