
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 22, 2024
This review describes the impact of COVID-19 on endocrine system, focusing cortisol signaling and growth factor-induced resistance. As expected, SARS-CoV-2 infection induces systemic inflammation, resulting in stimulation adrenal glands leading to elevated levels with normal adrenocorticotropic hormone (ACTH) levels. The cytokine storm could also stimulate production. However, some instances, rise independently ACTH due a phenomenon known as “pseudo-Cushing’s syndrome,” where become less responsive ACTH. Plasma proteomic analyses showed that this pattern was variably observed among patients, potentially involving calcium dysregulation GNAS-regulated activities, ultimately impacting regulation microvascular permeability. exhibited syndrome resembling resistance, governed by receptor tyrosine kinase pathways. Mild cases displayed activity EGFR MMP9, along increased expression survival factors like Bax Bcl2. In contrast, more severe involved IGFR-I enhanced NOTCH signaling, altered Bcl2, AKT1, MAPK8. summary, these findings describe complex interplay between pathology, particularly These insights suggest potential targets for therapeutic interventions improve short- long-term outcomes patients.
Language: Английский