Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 22, 2024

Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to post-acute sequelae of SARS-CoV-2 (PASC) that persist for weeks years following initial viral infection. Clinical manifestations PASC are heterogeneous and often involve multiple organs. While many hypotheses have been made on the mechanisms its associated symptoms, biological drivers still unknown. We enrolled 494 patients with COVID-19 at their presentation a hospital or clinic followed them longitudinally determine development PASC. From 341 patients, we conducted multi-omic profiling peripheral blood samples collected shortly after study enrollment investigate early immune signatures During first week COVID-19, observed large number differences in profile individuals who were hospitalized compared those not hospitalized. Differences between did later develop were, comparison, more limited, but included significant autoantibodies epigenetic transcriptional double-negative 1 B cells, particular. found indicators incident nuanced, molecular signals manifesting predominantly robust hospitalization during COVID-19. The emerging cell phenotypes, especially highlight potentially important role these cells

Language: Английский

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Haematological Manifestations of SARS-CoV-2: Insights into Erythropoiesis, Hepcidin Regulation, and Cytokine Storm

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 874 - 874

Published: Jan. 21, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a disease that can range in presentation from mild symptoms to severe conditions such as pneumonia and distress syndrome. SARS-CoV-2, single-stranded RNA virus, spreads through aerosols droplets. It enters human cells by binding the angiotensin-converting enzyme receptor, leading various complications, including significant alterations red blood potential disruptions haemoglobin function oxygen transport. During infection, interaction between hypoxia, inflammation, haematopoiesis affects erythropoiesis at multiple levels. Hypoxia resulting lung complications reduced cell count, influence regulation of hepcidin, key regulator iron levels blood. Elevated hepcidin are associated with hypoxia suppression erythroferrone, hormone normally inhibits production. Despite high patients intensive care units often exhibit elevated ferritin levels, which, rather than indicating low suggest disrupted metabolism development anaemia. Iron is kept stores, likely due paradoxically which explains measurements. An increase immature decrease CD71+ erythroid observed. The highlight their dual role modulating hyper-inflammation immune response during progression. This review examines pathway SARS-CoV-2 production haematopoietic system how it triggers cytokine storms interleukins, cells, cells. Understanding these processes provides novel pathways for managing haematological manifestations responses COVID-19.

Language: Английский

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Clinical and Biomarker Profile Responses to Rehabilitation Treatment in Patients with Long COVID Characterized by Chronic Fatigue

Viruses, Journal Year: 2023, Volume and Issue: 15(7), P. 1452 - 1452

Published: June 27, 2023

Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond >12 weeks after SARS-CoV-2 infection. The most frequently associated fatigue. Physical activity and exercise are recommended, although specific studies lacking. objectives of the present work to analyze impact supervised program on clinical evolution LC with fatigue patients identify whether certain circulating biomarkers could predict response rehabilitation. rehabilitation treatment was analyzed in 14 women diagnosed fatigue, based changes 6 min walk test Borg/Fatigue Impact scales. Patients who showed improvement meters walked were considered "responders" therapy. A total 65% responded program, an oxygen saturation, stability percentage walked. Participants obesity those double-vaccinated against presented lower degree favorable program. Differences creatinine protein levels observed between therapy "nonresponders". good state nutrition related better response. results promising regarding possible predictive response, such as creatinine.

Language: Английский

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Immunomodulation of adipose-derived mesenchymal stem cells on peripheral blood mononuclear cells in colorectal cancer patients with COVID-19

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(5), P. 2113 - 2122

Published: May 7, 2024

Accumulating evidence has shown that adipose tissue-derived mesenchymal stem cells (ADSCs) are an effective therapeutic approach for managing coronavirus disease 2019 (COVID-19); however, further elucidation is required to determine their underlying immunomodulatory effect on the mRNA expression of T helper cell-related transcription factors (TFs) and cytokine release in peripheral blood mononuclear (PBMCs).

Language: Английский

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An HERV-W ENV transcription in atypical memory B cells linked to COVID-19 evolution and risk for long COVID can express the encoded protein from a ribosome readthrough of mRNA from chromosome X.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

ABSTRACT The human genome comprises 8% of endogenous retroviruses (HERVs). Though HERVS contribute to physiological functions, copies retained pathogenic potential. HERV-W ENV protein was shown expressed in patients with worse COVID-19 symptoms and post-COVID syndrome. A significant detection the mRNA encoding from B cells RNAseq reads obtained peripheral blond mononuclear cells. This data stratified increased or post-acute sequelae (long COVID) after 3 months. ENV-U3R RNA confirmed display best alignment chromosome X ERVWE2 locus. However, a stop codon precluding its translation re-addressed recent understandings ribosome readthrough mechanisms. Experimental results evidenced that this HERV gene can effectively express full-length presence molecules allowing via mechanism at level. Results not only confirm origin these patients, but show for first time how defective copy be translated into complete when specific factors make it possible present proof concept now requires further studies identify involved newly understood mechanism, following SARS-CoV-2 exposure.

Language: Английский

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HERV-W ENV transcription in B cells predicting symptomatic COVID-19 and risk for long COVID can express a full-length protein despite stop codon in mRNA from chromosome X via a ribosome readthrough.

Microbes and Infection, Journal Year: 2024, Volume and Issue: unknown, P. 105431 - 105431

Published: Oct. 1, 2024

Language: Английский

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