The therapeutic targets and signaling mechanisms of ondansetron in the treatment of critical illness in the ICU DOI Creative Commons
Lili Tao, Zhenhui Zhang, Chuang Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 21, 2024

Background There is accumulating evidence regarding the benefits of 5-HT 3 receptor antagonist ondansetron for treatment critical illness due to its potential anti-inflammatory effect. This study attempted determine targets and molecular mechanisms ondansetron’s action against illnesses. Methods A bioinformatics analysis network pharmacology was conducted demonstrate screening signaling pathways most common illnesses such as acute kidney injury (AKI), sepsis, respiratory distress syndrome (ARDS). Experiments LPS-stimulated rat neutrophils with were further validate relevant hypothesis. Results total 198, 111, 26 primary causal identified from data AKI, ARDS respectively. We found that pathway neutrophil extracellular traps (NETs) formation statistically significantly involved in these three In NETs formation, drug-disease intersection toll-like 8 ( TLR8 ), mitogen-activated protein kinase-14 MAPK14 nuclear factor kappa-B1 NFKB1 elastase NE myeloperoxidase MPO ). Considering findings, we concluded anti-critical effects are mechanistically pharmacologically implicated suppression neutrophils-associated inflammatory processes. It also showed after ondansetron, key proteins NE, MPO, Peptide Arginine Deaminase 4 (PAD4) reduced, factors IL-6, IL-1β, TNF-α, chemokine (CXCR4) decreased. Conclusion The excessive may have important research value development progression illness. Ondansetron reduce diseases by reducing via influencing five targets: TLR8, NFKB1, MAPK14, . predictive biotargets potentially be used treat future clinical practice.

Language: Английский

Enzyme-mediated green synthesis of glycosaminoglycans and catalytic process intensification DOI
Jie Zheng,

Xiao-Jun Lin,

Xu Han

et al.

Biotechnology Advances, Journal Year: 2024, Volume and Issue: 74, P. 108394 - 108394

Published: June 8, 2024

Language: Английский

Citations

5
Indoxyl sulfate (IS) mediates pro-inflammatory responses in severe pneumonia in patients with rheumatoid arthritis associated interstitial lung disease DOI
Minghua Zhan, Ziyao Li, Jianing Chen

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110430 - 110430

Published: Jan. 1, 2025

Language: Английский

Citations

0
Management of Patients With COVID-19 During the Pandemic: A Retrospective Cohort Study From a Tertiary Care Centre in Mumbai, India DOI Open Access

Neeraj Kumar Tulara,

Swapnil Mehta,

Vimal Pahuja

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
A narrative review of chemokine receptors CXCR1 and CXCR2 and their role in acute respiratory distress syndrome DOI Creative Commons

Sophie Toya,

Sofie Struyf,

Luis Huerta

et al.

European Respiratory Review, Journal Year: 2024, Volume and Issue: 33(173), P. 230172 - 230172

Published: July 1, 2024

Acute respiratory distress syndrome (ARDS) is a severe form of acute failure characterised by extensive inflammatory injury to the alveolocapillary barrier leading alveolar oedema, impaired gas exchange and, ultimately, hypoxaemia necessitating use supplemental oxygen combined with some degree positive airway pressure. Although much heterogeneity exists regarding aetiology, localisation and endotypic characterisation ARDS, what remains largely undisputed role innate immune system, in particular neutrophils, precipitating propagating lung injury. Activated recruited through chemokine gradients, promote releasing oxidants, proteases neutrophil extracellular traps, which ultimately cause platelet aggregation, microvascular thrombosis cellular death. Among various neutrophilic chemoattractants, interleukin-8/C-X-C motif ligand 8 related chemokines, collectively called ELR+ acting on neutrophils G protein-coupled receptors CXCR1 CXCR2, are pivotal orchestrating activation status chemotaxis inflamed lung. This allows efficient elimination infectious agents while at same time minimising collateral damage host tissue. Therefore, understanding how CXCR2 regulated important if we hope effectively target them for therapeutic ARDS. In following narrative review, provide an overview chemokines (ALI) summarise relevant regulatory pathways their cognisant CXCR1/2 highlight current preclinical clinical evidence inhibition animal models ALI, as well ARDS patients.

Language: Английский

Citations

1
Global research trends on sepsis and septic shock during 2003–2022: A data-driven bibliometric analysis DOI Creative Commons

Weiying Han,

Haoxin Guo,

Zhongqing Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 15, 2024

Abstract Background Sepsis is a major medical condition that contributes to substantial morbidity and mortality rates worldwide. Research better understand manage these complex conditions has intensified over the past two decades. This bibliometric analysis aims map global research trends in sepsis septic shock from 2003 2022, providing insights into evolution of field. Methods study conducted comprehensive search for publications on using Web Science Core Collection. Data were analysed VOSviewer mapping, focusing publication trends, country, institutional contributions, journal sources, citation analysis, keyword co-occurrence. Results In total, 78,108 retrieved, with notable increase annual output period. The United States ranked first volume, followed by China, Germany, Kingdom. Harvard University was most prolific institution. Critical Care Medicine emerged as leading terms count. cited articles references predominantly related definition, epidemiology, management guidelines sepsis. Recent hotspots included COVID-19, machine learning applications, NLRP3 inflammasome, autophagy, gut microbiota, microRNA (miRNA). Conclusions Our identifies 20 years, evolving increasing collaboration. Key findings highlight continuous efforts pathophysiology shock. (miRNA) are hotspots.

Language: Английский

Citations

0
The therapeutic targets and signaling mechanisms of ondansetron in the treatment of critical illness in the ICU DOI Creative Commons
Lili Tao, Zhenhui Zhang, Chuang Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 21, 2024

Background There is accumulating evidence regarding the benefits of 5-HT 3 receptor antagonist ondansetron for treatment critical illness due to its potential anti-inflammatory effect. This study attempted determine targets and molecular mechanisms ondansetron’s action against illnesses. Methods A bioinformatics analysis network pharmacology was conducted demonstrate screening signaling pathways most common illnesses such as acute kidney injury (AKI), sepsis, respiratory distress syndrome (ARDS). Experiments LPS-stimulated rat neutrophils with were further validate relevant hypothesis. Results total 198, 111, 26 primary causal identified from data AKI, ARDS respectively. We found that pathway neutrophil extracellular traps (NETs) formation statistically significantly involved in these three In NETs formation, drug-disease intersection toll-like 8 ( TLR8 ), mitogen-activated protein kinase-14 MAPK14 nuclear factor kappa-B1 NFKB1 elastase NE myeloperoxidase MPO ). Considering findings, we concluded anti-critical effects are mechanistically pharmacologically implicated suppression neutrophils-associated inflammatory processes. It also showed after ondansetron, key proteins NE, MPO, Peptide Arginine Deaminase 4 (PAD4) reduced, factors IL-6, IL-1β, TNF-α, chemokine (CXCR4) decreased. Conclusion The excessive may have important research value development progression illness. Ondansetron reduce diseases by reducing via influencing five targets: TLR8, NFKB1, MAPK14, . predictive biotargets potentially be used treat future clinical practice.

Language: Английский

Citations

0