Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew DOI Creative Commons
Shawn G. Rhind, Maria Y. Shiu, Oshin Vartanian

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1296 - 1296

Published: Dec. 23, 2024

Background/Objectives: Military aviators can be exposed to extreme physiological stressors, including decompression stress, G-forces, as well intermittent hypoxia and/or hyperoxia, which may contribute neurobiological dysfunction/damage. This study aimed investigate the levels of neurological biomarkers in military assess potential risk long-term brain injury and neurodegeneration. Methods: cross-sectional involved 48 Canadian Armed Forces (CAF) non-aviator CAF controls. Plasma samples were analyzed for glial activation (GFAP), axonal damage (NF-L, pNF-H), oxidative stress (PRDX-6), neurodegeneration (T-tau), along with S100b, NSE, UCHL-1. The biomarker concentrations quantified using multiplexed immunoassays. Results: exhibited significantly elevated GFAP, NF-L, PRDX-6, T-tau compared controls (p < 0.001), indicating increased activation, injury, stress. Trends toward higher UCHL-1 observed but not statistically significant. suggest cumulative damage, raising concerns about impairments. Conclusions: are at early These findings emphasize importance proactive monitoring further research understand impacts high-altitude flight on health develop strategies mitigating cognitive decline neurodegenerative risks this population.

Language: Английский

Genetic and peripheral biomarkers of comorbid posttraumatic stress disorder and traumatic brain injury: a systematic review DOI Creative Commons
Kiriana K. Cowansage,

Reshmi Nair,

Jose Lara‐Ruiz

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Background Posttraumatic stress disorder (PTSD) commonly cooccurs with traumatic brain injury (TBI) in military populations and is a significant predictor of poor long-term outcomes; however, it unclear to what extent specific biological variables are associated comorbidity. This PROSPERO-registered systematic review evaluates the current body literature on genetic peripheral biomarkers comorbid TBI PTSD. Methods Searches were conducted four databases (PubMed, PsycInfo, PTSDPubs, Scopus). We included published studies examining differences among civilian, military, veteran participants both PTSD compared those alone as well as, some cases, healthy controls. Data extracted from evidence quality was assessed. Results Our final analysis 16 studies, majority which based data active duty participants. The results suggest that multiple gene variants likely contribute cumulative risk TBI. An elevated circulating level pro-inflammatory cytokine IL-6 most consistently replicated blood-based indicator illness, mTBI alone. Conclusion Several protein markers cellular inflammation appear be promising indicators chronic pathology Additional research needed determine how such factors indicate, predict, comorbidity they represent viable targets for development novel diagnostic tools therapeutic interventions.

Language: Английский

Citations

0
Feasibility of transcription factor EB as a serological metric of poor prognosis following moderate–severe traumatic brain injury: A prospective cohort study DOI Creative Commons
Li Zhang,

Haiying Ma,

Xiaobing Zhang

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(18), P. e42271 - e42271

Published: May 2, 2025

Transcription factor EB (TFEB) is an endogenous protective factor. Here, we sought to discern the possibility of serum TFEB as a prognostic biomarker moderate–severe traumatic brain injury (msTBI). Serum levels 141 patients with msTBI and 70 controls were quantified in this prospective cohort study. Rotterdam computed tomography (CT) classification Glasgow coma scale (GCS) considered severity metrics. outcome (GOS) scores 1 3 at 6 months after trauma meant poor prognosis. The results analyzed using multivariate analysis. Patients versus had notable reduction levels. independent correlation CT GCS independently relevant continuous GOS ordinal scores. linear relation risk prognosis under restricted cubic spline predictive Using receiver operating characteristic curve analysis, displayed analogous ability constructed model by merging predictors, that TFEB, scores, was pictorially exhibited via nomogram, demonstrated perform well adopting several statistical approaches. An obvious decline subsequent are firmly related neurological outcomes patients, reinforcing clinical meaningfulness biochemical indicator msTBI.

Language: Английский

Citations

0
A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative DOI

Geoffrey T. Manley,

Kristen Dams-O’Connor, Michael L. Alosco

et al.

The Lancet Neurology, Journal Year: 2025, Volume and Issue: 24(6), P. 512 - 523

Published: May 20, 2025

Language: Английский

Citations

0
Letter to the editor for: “A systematic review and meta-analysis of major blood protein biomarkers that predict unfavorable outcomes in severe traumatic brain injury” DOI

Marios Lampros,

George Α. Alexiou,

Lamprini Vlachodimitropoulou

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 243, P. 108366 - 108366

Published: June 5, 2024

Language: Английский

Citations

0
Unveiling the predictive power of biomarkers in traumatic brain injury: A narrative review focused on clinical outcomes DOI Creative Commons
Shuang Liang,

Zihui Hu

Biomedical Papers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Traumatic brain injury (TBI) has long-term consequences, including neurodegenerative disease risk. Current diagnostic tools are limited in detecting subtle damage. This review explores emerging biomarkers for TBI, those related to neuronal injury, inflammation, EVs, and ncRNAs, evaluating their potential predict clinical outcomes like mortality, recovery, cognitive impairment. It addresses challenges opportunities implementing practice, aiming improve TBI diagnosis, prognosis, treatment.

Language: Английский

Citations

0
Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew DOI Creative Commons
Shawn G. Rhind, Maria Y. Shiu, Oshin Vartanian

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1296 - 1296

Published: Dec. 23, 2024

Background/Objectives: Military aviators can be exposed to extreme physiological stressors, including decompression stress, G-forces, as well intermittent hypoxia and/or hyperoxia, which may contribute neurobiological dysfunction/damage. This study aimed investigate the levels of neurological biomarkers in military assess potential risk long-term brain injury and neurodegeneration. Methods: cross-sectional involved 48 Canadian Armed Forces (CAF) non-aviator CAF controls. Plasma samples were analyzed for glial activation (GFAP), axonal damage (NF-L, pNF-H), oxidative stress (PRDX-6), neurodegeneration (T-tau), along with S100b, NSE, UCHL-1. The biomarker concentrations quantified using multiplexed immunoassays. Results: exhibited significantly elevated GFAP, NF-L, PRDX-6, T-tau compared controls (p < 0.001), indicating increased activation, injury, stress. Trends toward higher UCHL-1 observed but not statistically significant. suggest cumulative damage, raising concerns about impairments. Conclusions: are at early These findings emphasize importance proactive monitoring further research understand impacts high-altitude flight on health develop strategies mitigating cognitive decline neurodegenerative risks this population.

Language: Английский

Citations

0