Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 40(1)
Published: Nov. 21, 2024
Language: Английский
Schizophrenia Research Cognition, Journal Year: 2024, Volume and Issue: 38, P. 100328 - 100328
Published: Aug. 29, 2024
Background: In the last decade, kynurenine pathway (KP) has gained attention in pathogenesis of cognitive impairment schizophrenia being at croassroad between neuroinflammation and glutamatergic cholinergic neurotransmission.However, clinical findings are scarse conflicting, specific contributions these two systems to neurobiology symptoms far from elucidated.Furthermore, little is known about molecular underpinnings non-pharmacological interventions for improvement, including rehabilitation strategies.Methods: The current study examined 72 patients with schizophrenia, divided clusters depending on severity impairment, aim evaluate impact inflammatory biomarkers KP metabolites functioning.Moreover, we studied their possible link outcome relation sessions remediation therapy (CRT) aerobic exercise (AE) a longitudinal arm 42 patients.Results: Neuroinflammation appeared exert more pronounced influence cognition exhibiting higher functioning, contrasting activation KP, which had greater individuals lower profile.Cognitive improvements after treatments were negatively predicted by levels TNF-α positively 3-hydroxykynurenine (3-HK)/kynurenine (KYN) ratio, an index kynurenine-3-monooxygenase (KMO) enzyme activity.Conclusion: Overall, add novel evidence biological pointing differential role inducing deficits reserve predicting outcomes rehabilitation.
Language: Английский
Citations
6
BioMedInformatics, Journal Year: 2025, Volume and Issue: 5(1), P. 8 - 8
Published: Feb. 5, 2025
EEG microstates are brief, stable topographical configurations of brain activity that provide insights into alterations in function and connectivity. Anomalies associated with different neuropsychiatric conditions, especially schizophrenia. Recent advances both techniques machine learning point to the potential role as diagnostic markers for psychotic disorders. This systematic review aims gather current knowledge on applied microstate analysis Following PRISMA guidelines, we searched Scopus, PubMed, Scholar databases, including 10 studies. Overall results show can be used accurately classify diagnoses within psychosis spectrum, across all stages, outperforming models based conventional measures, a prominent D. One study also suggests anomalies may directly linked symptom severity. Integrating shows promise improving our understanding disorders developing more precise tools.
Language: Английский
Citations
0
Neuropsychologia, Journal Year: 2025, Volume and Issue: unknown, P. 109094 - 109094
Published: Feb. 1, 2025
Language: Английский
Citations
0
Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 176 - 176
Published: March 5, 2025
The biology of schizophrenia is highly complex and multifaceted. Numerous efforts have been made over the years to disentangle heterogeneity disease, gradually leading a more detailed understanding its underlying pathogenic mechanisms. Two cardinal elements in pathophysiology are neuroinflammation alterations neurotransmission. kynurenine (KYN) pathway (KP) particular importance because it inducted by systemic low-grade inflammation peripheral tissues, producing metabolites that neuroactive (i.e., modulating glutamatergic cholinergic neurotransmission), neuroprotective, or neurotoxic. Consequently, KP at crossroads between two primary systems involved pathogenesis schizophrenia. It bridges central nervous system (CNS) periphery, as can cross blood–brain barrier modulate neuronal activity. Metabolic syndrome plays crucial role this context, frequently co-occurs with schizophrenia, contributing sub-inflammatory state able activate KP. This narrative review provides valuable insights into these interactions, offering framework for developing targeted therapeutic interventions precision psychiatry approaches disorder.
Language: Английский
Citations
0
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
Language: Английский
Citations
3
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 4, 2024
Background Inhibitory control deficits are a core feature of cognitive impairment in schizophrenia, associated with abnormal activation key brain networks. Repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC) may help improve inhibitory control, but its specific effects schizophrenia remain uncertain. Methods This study involved 150 participants divided into Real-rTMS, Sham-rTMS, and healthy groups. was assessed using dual-choice oddball task, task-based functional resonance imaging (fMRI) employed to examine neural activity. The Real-rTMS group received active over DLPFC, Sham placebo stimulation. Results exhibited significant improvements both reaction times accuracy compared group, indicating enhanced control. fMRI data showed that activity regions such as cerebellum, insula, thalamus, normalized patterns closely resembling those observed controls. Additionally, revealed restoration further enhancement negative like middle frontal gyrus superior temporal gyrus, which helped reduce interference from irrelevant stimuli. Conclusion rTMS DLPFC improves by modulating positive patterns. These findings highlight dual mechanism through enhances offering promising intervention for schizophrenia. Future research should explore long-term this modulation on broader functions.
Language: Английский
Citations
1
Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 40(1)
Published: Nov. 21, 2024
Language: Английский
Citations
1