Stimulation Parameters Recruit Distinct Cortico-Cortical Pathways: Insights from Microstate Analysis on TMS-Evoked Potentials

Brain Topography, Journal Year: 2025, Volume and Issue: 38(3)

Published: March 28, 2025

Abstract Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) represent an innovative measure for examining brain connectivity and developing biomarkers of psychiatric conditions. Minimizing TEP variability across studies participants, which may stem from methodological choices, is therefore vital. By combining classic peak analysis microstate investigation, we tested how TMS pulse waveform current direction affect cortico-cortical circuit engagement when targeting the primary motor cortex (M1). We aim to disentangle whether changing these parameters affects degree activation same neural circuitry or lead changes in pathways through induced spreads. Thirty-two healthy participants underwent a TMS-EEG experiment (monophasic, biphasic) (posterior-anterior, anterior-posterior, latero-medial) were manipulated. assessed latency amplitude M1-TEP components employed analyses test differences topographies. Results revealed that strongly influenced components’ but had weaker role over their latencies. Microstate showed monophasic stimulations changed pattern evoked microstates at early latencies, as well duration global field power. This study shows pulses modulate cortical sources contributing signals, activating populations paths more selectively. Biphasic reduces associated with be better suited blind anatomical information.

Language: Английский

Transcranial Magnetic Stimulation–Electroencephalography (TMS-EEG) in Neurosurgery: Unexplored Path Towards Personalized Brain Surgery

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1144 - 1144

Published: Dec. 9, 2024

Transcranial Magnetic Stimulation-Electroencephalography (TMS-EEG) is a non-operative technique that allows for magnetic cortical stimulation (TMS) and analysis of the electrical currents generated in brain (EEG). Despite regular utilization both techniques independently, little known about potential impact their combination neurosurgical practice.

Language: Английский