Effects of Dietary Habits on Markers of Oxidative Stress in Subjects with Hashimoto’s Thyroiditis: Comparison Between the Mediterranean Diet and a Gluten-Free Diet

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 363 - 363

Published: Jan. 20, 2025

Background: The Mediterranean diet (MedD) exerts anti-inflammatory and anti-oxidant effects that are beneficial in autoimmune thyroid diseases (ATD). Recently, a gluten-free (GFD) has been proposed for non-celiac patients with Hashimoto’s thyroiditis (HT), but its usefulness is under debate. present pilot study evaluates the of these two dietary regimes, focus on redox homeostasis, HT. Patients Methods: 45 euthyroid HT (30 F; median age 42 years) were randomly assigned to different regimes: MedD (n = 15), GFD 15) free (FD, n 15). Thyroid function tests, autoantibodies, oxidative stress markers (Advanced glycation end products, AGEs; glutathione peroxidase (GPx), thioredoxin reductase (TRxR), total plasma antioxidant activity (TEAA) measured at baseline after 12 weeks. Results: In group, significantly lower values AGEs higher GPX, TRX TEAA action detected (p < 0.05) weeks compared baseline, FD groups, which parameters did not change > 0.05). No significant differences serum levels TSH, FT4, Ab-Tg, Ab-TPO found any group. Conclusions: This confirms protective effect against stress, while does influence and/or autoimmunity/function parameters.

Language: Английский

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Dietary Factors Influencing the Intensity of Low-Grade Inflammation in Obesity

Obesities, Journal Year: 2025, Volume and Issue: 5(1), P. 12 - 12

Published: March 1, 2025

According to WHO (World Health Organization), in 2022, 43% of adults worldwide were overweight and 16% suffered from obesity. Overweight obesity is a condition which the body, due excess consumed calories, accumulates it form adipose tissue. However, this tissue not only an energy store but also secretes numerous adipokines, mainly with pro-inflammatory effects. The mobilization immune system accumulation called low-grade inflammation (LGI) mediating factor between body weight diseases such as cardiovascular disease, insulin resistance, type 2 diabetes, neurodegenerative diseases, sleep apnea, even cancer. aim review update reports related dietary factors influencing severity or alleviation obese people. used studies PubMed Google Scholar last 10 years. results indicate that Western diet, rich processed foods, high levels saturated fatty acids, simple sugars, salt, low fiber nutrient content (vitamins minerals), leads increased inflammation. On other hand, calorie restrictions appropriate balance macronutrients, antioxidant anti-inflammatory nutrients (e.g., polyphenols, vitamins A, C, E, selenium) may reduce LGI, reducing risk obesity-related diseases.

Language: Английский

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Epigenetic Aging Acceleration in Obesity Is Slowed Down by Nutritional Ketosis Following Very Low-Calorie Ketogenic Diet (VLCKD): A New Perspective to Reverse Biological Age

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1060 - 1060

Published: March 18, 2025

Background/Objectives: Epigenetic clocks have emerged as a tool to quantify biological age, providing more accurate estimate of an individual’s health status than chronological helping identify risk factors for accelerated aging and evaluating the reversibility therapeutic strategies. This study aimed evaluate potential association between epigenetic acceleration age obesity, well determine whether nutritional interventions body weight loss could slow down this acceleration. Methods: Biological was estimated using three (Horvath (Hv), Hannum (Hn), Levine (Lv)) based on leukocyte methylome analysis individuals with normal (n = 20), obesity 24), patients following VLCKD 10). We analyzed differences in estimates, relationship impact VLCKD. Correlations were assessed acceleration, BMI, various metabolic parameters. Results: Analysis revealed (Hv +3.4(2.5), Hn +5.7(3.2), Lv +3.9(2.7)) compared slight deceleration weight. correlated BMI (p < 0.0001). Interestingly, showed both ketosis −3.3(4.0), −6.3(5.3), −8.8(4.5)) at endpoint −1.1(4.3), −7.4(5.6), −8.2(5.3)). Relevantly, slowdown is associated 0.0001), ketonemia ≤ 0.001), parameters 0.05). Conclusions: Our findings highlight applicability monitor obesity-related precision medicine show efficacy slowing aging.

Language: Английский

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Nutritional ketosis modulates the methylation of cancer-related genes in patients with obesity and in breast cancer cells

Journal of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

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Advancing Obesity Management: the Very Low-Energy Ketogenic therapy (VLEKT) as an Evolution of the “Traditional” Ketogenic Diet

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 3, 2025

This narrative review comprehensively analyzes VLEKT as an advanced nutritional strategy for obesity management. The focus is on the beneficial effects key disease organs, such adipose tissue and liver, well modulation of intestinal permeability its fundamental role in influencing gut microbiota inflammatory pathways. impact obesity-related comorbidities, including metabolic syndrome, cardiovascular disease, endocrine disorders, dysfunction-associated steatotic liver (MASLD), neurological kidney alterations, also investigated. Moreover, to assess wider application treatment, combination ketogenic regimes with additional strategies physical activity, bariatric surgery, digital health technologies examined. Despite promising clinical results, adherence potential deficiencies require careful follow-up individualized programming monitored by specialists. Future research should elucidating molecular mechanisms underlying physiological systems, long-term safety. Nevertheless, innovative approach offering a target-oriented highly effective people fighting against overweight associated medical complications. Obesity multifactorial chronic numerous comorbidities; given increasing prevalence, personalized intervention are crucial inhibit "obesity pandemic" according "food re-educational" protocol. Among dietary interventions, diet (KD) has attracted attention effectiveness weight management benefits. A variant, very low-calorie (VLCKD), more recently defined low-energy (VLEKD), combines benefits ketosis substantial calorie restriction, improving overall health.

Language: Английский

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Ketogenic diet improves disease activity and cardiovascular risk in psoriatic arthritis: A proof of concept study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321140 - e0321140

Published: April 22, 2025

Objectives Very low-calorie ketogenic diet (VLCKD) is a low-carbohydrate, regimen that leads to rapid weight loss and may reduce inflammation. This study assessed the impact of VLCKD on anthropometric measurements, inflammatory biomarkers, metabolic health, cardiovascular risk in psoriatic arthritis (PsA) patients moderately overweight or class I obesity. Methods A proof-of-concept single-arm monocentric involved PsA undergoing 9-week treatment. Patients with Body Mass Index (BMI) ≥27 <35, stable (≥6 months) remission low disease activity, as defined by Disease Activity PSoriatic Arthritis (DAPSA) score, were included underwent nutritional evaluations every 3 weeks. The analyzed changes after intervention association between parameters clinical laboratory variables. Results Twenty enrolled since April 2022 completed May 2023. Median baseline BMI was 30.9 (interquartile range 29.1–33) kg/m². All participants exhibited which correlated (Spearman’s correlation coefficient (r s )=0.59,p=0.007). Following VLCKD, significant improvements observed all measures (BMI -3.5[-4;-2.6]), activity (DAPSA -6.1[-16.8;3.7]), (SCORE2 index -0.2[-0.7;0.1]), insulin resistance (Homeostatic Model Assessment-Insuline Resistance -2.1[-1.1;-3.0]), lipid profile. Most biomarkers remained within normal limits. reduction DAPSA scores =0.52,p=0.020). higher experienced more pronounced improvements. Conclusions significantly improved health. less controlled are particularly motivated could benefit from compared those lower better control.

Language: Английский

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Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions

Immuno, Journal Year: 2022, Volume and Issue: 3(1), P. 1 - 15

Published: Dec. 25, 2022

Interceding nutrients have been acquiring increased attention and prominence in the field of healing deterrence various disorders. In this light, present article encompasses several facets ketogenic diet as an immunomodulator with respect to its expansive clinical applications. Accordingly, scientific records, models, case histories, including viral infections, cancer, chronic diseases, e.g., cardiovascular epilepsy, well numerous other neuro-disorders, are assembled, revealing a profound influence KD favor improvement patient’s condition. We accentuate possible manifold mechanisms that require further exploration.

Language: Английский

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Very low energy diets prior to bariatric surgery may reduce postoperative morbidity: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: June 20, 2023

To optimize patients prior to bariatric surgery, very low energy diets (VLEDs) are often employed for 2-4 weeks preoperatively. They known result in preoperative weight loss, decrease liver volume, and surgeon-perceived operative difficulty. Their impact on postoperative morbidity has been less extensively studied. We performed a focused systematic review meta-analysis with the aim of comparing VLEDs surgery controls terms overall morbidity.MEDLINE, Embase, CENTRAL were searched from database inception February 2023. Articles eligible inclusion if they randomized controlled trials (RCTs) adult (i.e., over age 18) receiving VLED liquid formulation those non-VLED control elective surgery. Outcomes included 30-day loss. An inverse variance was GRADE assessment quality evidence.After reviewing 2,525 citations, four RCTs 294 met inclusion. Patients experienced significantly more loss than (mean difference (MD) 3.38 kg, 95% confidence interval (CI) 1.06-5.70, p = 0.004, I2 95%). According certainty evidence, there non-significant reduction (risk ratio (RR) 0.67, 95%CI 0.39-1.17, 0.16, 0%).The outcomes following remains unclear. It is possible that may contribute decreased morbidity, but further larger prospective required investigate signal identified this study.

Language: Английский

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A very-low-calorie ketogenic diet normalises obesity-related enhanced levels of erythropoietin compared with a low-calorie diet or bariatric surgery

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(11), P. 2701 - 2713

Published: May 2, 2024

Language: Английский

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Investigating the Effectiveness of a Carb-Free Oloproteic Diet in Fibromyalgia Treatment

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1620 - 1620

Published: May 25, 2024

Fibromyalgia (FM), a chronic disease with high incidence in women, poses significant challenge for diagnosis and treatment, especially due to the absence of specific biomarkers multifaceted nature its symptoms, which range from neuromuscular pain mood disorders intestinal dysbiosis. While currently relies on rheumatological clinical evaluations treatment options mainly focus symptom management, FM seems have possible links systemic metabolic dysfunctions common inflammatory root. In this context, new therapeutic avenue emerges: could nutritional approach be missing piece puzzle? Indeed, diet therapies employed particularly syndromes proved recently efficacious correcting dysmetabolism number inflammation conditions. particular, very-low-calorie ketogenic (VLCKD) demonstrated benefits many disorders. present study, we aimed investigate effects two dietary interventions, namely oloproteic VLCKD low-glycemic insulinemic (LOGI) diet, groups female patients (FM1 FM2) over 45-day period. Utilizing laboratory tests, as well non-invasive NMR metabolomic analysis serum, urine, saliva samples, sought uncover how these regimens impact associated FM.

Language: Английский

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