Associations between ultra-processed food and drink consumption and biomarkers of chronic low-grade inflammation: exploring the mediating role of adiposity

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(4)

Published: April 9, 2025

Abstract Purpose Higher ultra-processed food and drink (UPFD) consumption has been linked with increased risk of non-communicable diseases. Low-grade systemic inflammation may partly underlie this relationship, yet limited research on UPFDs exists in context. We examined UPFD associations inflammatory biomarkers explored whether relationships are mediated by adiposity. Methods This was a cross-sectional study 1,986 middle- to older-aged men women. Using the NOVA classification, weight ratios were calculated for each participant. Correlation multivariate-adjusted linear regression analyses used test intake wide range biomarkers. Mediation independent or adiposity, defined body mass index (BMI) waist-height ratio (WHtR). Results Significant direct effects between higher levels interleukin 6, tumour necrosis factor-alpha, white blood cell counts constituent neutrophils, basophils, neutrophil-to-lymphocyte ratio, observed models which controlled potential confounders, additionally adjusted BMI WHtR. adiposity found mediate biomarkers, percentage total effect ranging from 12.7 70.1% including BMI, 13.5 64.5% Conclusions Consumption is associated less optimal biomarker profile concentrations likely due both related pro-inflammatory products.

Language: Английский

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Impact of Ultra-processed Foods on Human Health: A Comprehensive Review of Genomic Instability and Molecular Mechanisms

Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 112800 - 112800

Published: April 1, 2025

Language: Английский

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Dietary Relationships between Obesity and Inflammatory Bowel Diseases: A Narrative Review of Diets Which May Promote Both Diseases

Current Gastroenterology Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 30, 2025

Language: Английский

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Joint Analysis of Diet Quality, Inflammatory Potential of Diet and Ultra-Processed Food Exposure in Relation to Chronic Respiratory Diseases and Lung Cancer Mortality

Respiratory Medicine, Journal Year: 2025, Volume and Issue: 243, P. 108138 - 108138

Published: May 2, 2025

Language: Английский

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Ultra-processed food consumption and cardiometabolic risk in Canada: a cross-sectional analysis of the Canadian health measures survey

Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 7, 2025

Language: Английский

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Is Ultra-Processed Food Intake Associated with a Higher Risk of Glaucoma? A Prospective Cohort Study including 19,255 Participants from the SUN Project

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1053 - 1053

Published: April 4, 2024

Objective: The aim of this study was to examine the relationship ultra-processed food (UPF) intake with incidence glaucoma in a large sample Spanish university graduates followed prospectively. Methods: Prospective cohort using data from SUN Project. A final 19,225 participants (60.1% women) included study, mean age 38.2 years (standard deviation (SD) = 12.4). Participants were followed-up for time 12.9 (SD 5.4). Dietary measured 136-item semiquantitative food-frequency questionnaire. UPFs defined based on NOVA classification system. Glaucoma diagnosis determined by asking if they had ever been diagnosed an ophthalmologist. This self-reported has previously validated. Results: After adjusting several covariates, highest UPF consumption at higher risk (hazard ratio (HR) 1.83; 95% confidence interval (CI) 1.06 3.17) when compared lowest category consumption. Regarding subgroup analyses, significant multiplicative interaction found (p 0.004) and omega 3:6 0.040). However, association between only older (aged ≥ 55 years), men, most physically active group, group non- or former smokers, those lower ratio, energy intake. contribution each type coming sweets showed risky effect (HR 1.51; CI 1.07 2.12). Conclusions: prospective shows that greater have developing Our findings emphasize relevance monitoring limiting as means preventing incidence.

Language: Английский

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The association between ultra‐processed food consumption and low‐grade inflammation in childhood: A cross‐sectional study

Nutrition Bulletin, Journal Year: 2024, Volume and Issue: 49(4), P. 538 - 549

Published: Oct. 13, 2024

This study aimed to investigate the relationship between amount of ultra-processed food (UPF) in diet and low-grade inflammation children. cross-sectional was conducted 50 healthy children recruited from attending Social Paediatrics Outpatient Clinic for follow-up normal developmental stages. Low-grade calculated by INFLA-score, dietary intake three 24-h recalls content analyses BeBiS™ software. The mean age included our 10.18 ± 3.98 years (5-17 years). UPF accounted 24.5% total daily energy In with higher scores (INFLA-score ≥ 2), grams percentage were found be significantly (p = 0.030 p 0.015, respectively). A weak positive correlation INFLA-score coming UPFs (r 0.350, < 0.01), average 0.313, 0.05), consumed 0.260, 0.05). linear regression model revealed that every one-unit increase (1%) caused an β 0.154-unit INFLA-score. It obesity not a mediator association percentages on instead, had significant direct showed increasing pattern parallel inflammation-score quartile classes (Q1 Q4) 33.3% Q1, 38.5% Q2, 53.8% Q3 66.7% Q4 0.049). conclusion, consumption children, independent obesity.

Language: Английский

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Association between Late-Eating Pattern and Higher Consumption of Ultra-Processed Food among Italian Adults: Findings from the INHES Study

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1497 - 1497

Published: March 20, 2023

Late eating is reportedly associated with adverse metabolic health, possibly through poor diet quality. We tested the hypothesis that meal timing could also be linked to food processing, an independent predictor of health outcomes. analysed data on 8688 Italians (aged > 19years) from Italian Nutrition & HEalth Survey (INHES) established in 2010–2013 throughout Italy. Dietary were collected a single 24 h dietary recall, and NOVA classification was used categorize foods according increasing levels processing: (1) minimally processed (e.g., fruits); (2) culinary ingredients butter); (3) canned fish); (4) ultra-processed (UPFs; e.g., carbonated drinks, meat). then calculated proportion (%) each group total weight eaten (g/d) by creating ratio. Subjects classified as early or late eaters based population’s median for breakfast, lunch dinner. In multivariable-adjusted regression models, reported lower intake (β = −1.23; 95% CI −1.75 −0.71), higher UPF 0.93; 0.60 1.25) reduced adherence Mediterranean Diet −0.07; −0.12 −0.03) compared eaters. Future studies are warranted examine whether increased consumption may underpin associations prior cohorts.

Language: Английский

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Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil

Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 2867 - 2867

Published: June 24, 2023

Background: Few studies have evaluated the association between diet-related inflammation and gastric adenocarcinoma (GA) evidence is scarce in Brazil. This study a pro-inflammatory diet GA. Methods: A multicenter case–control was conducted total of 1645 participants—492 cases, 377 endoscopy controls, 776 hospital controls—were included. Energy-adjusted Dietary Inflammatory Index (E-DIITM) scores were derived from validated food frequency questionnaire. We used binary multinomial logistic regression models for analysis GA, its subtypes (cardia non-cardia, intestinal, diffuse histological subtypes). Results: In cases versus diet, estimated by higher E-DII scores, associated with risk GA (ORQ4vsQ1: 2.60, 1.16–5.70), non-cardia (OR: 2.90, 1.06–7.82), subtype 3.93, 1.59–9.70). 2.70, 1.60–4.54), cardia 3.31, 1.32–8.24), 2.97, 1.64–5.39), both intestinal 2.82, 1.38–5.74) 2.50, 1.54–5.11) subtypes. Conclusions: provides that an increased requires inclusion sodium due to importance carcinogenesis.

Language: Английский

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Immune-Inflammatory Response in Lifespan. What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study

Published: June 6, 2024

Studying models of healthy aging and exceptional longevity is crucial to understand a possible signature as most them show resistance age-related diseases. In particular, semi- supercentenarians are highly selected group, having survived significant adversities, including the Spanish Flu COVID-19 pandemics, indicating distinctive immune system characteristics. This paper analyse inflammatory scores (INFLA-score, Systemic Inflammation Response Index (SIRI)) Aging-Related Immune Phenotype (ARIP) indicators calculated from dataset DESIGN project, 249 participants aged 19-111 years, trying immune-inflammatory (IMFLAM) role achieve longevity. Statistical analyses, linear regression one-way ANOVA, were performed explore correlations between these parameters age. Both INFLA-score SIRI showed increase with However, no statistical difference observed when analysing values for those other age groups, whose similar that adults less than younger centenariansRegarding ARIP values, it noteworthy comparing CD8 Naive/Effector differences supercentenarian group groups. These results support idea control IMFLAM response can promote extreme

Language: Английский

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