Gut microbiota and inflammatory factor characteristics in major depressive disorder patients with anorexia

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 2, 2024

Abstract Background This study aimed to explore the gut microbiota and inflammatory factor characteristics in major depressive disorder (MDD) patients with anorexia analyze correlation between factors, anorexia, HAMD scores. Methods 46 MDD healthy controls (HC) were included study. The divided into two groups according whether they had anorexia:20 without (MDA0 group) 26 (MDA1 group). We used Hamilton Depression Scale-24 (HAMD-24) evaluate depression status of all participants 16 S ribosomal RNA (16 rRNA)sequencing composition microbiota. Inflammatory factors peripheral blood such as C-reactive protein (CRP) detected using enzyme-linked immunosorbent assay (ELISA). Spearman’s analysis was scores, anorexia. Results 1). CRP significantly higher MDA0, MDA1, than HC. 2). An α-diversity shows: Simpson Pielou indices HC group are MDA1 ( P < 0.05). 3). β-diversity shows differences microbial communities group. 4). A showed that Blautia positively correlated level, whereas Faecalibacterium, Bacteroides, Roseburia, Parabacteroides negatively level. 5). receiver operating characteristic (ROC) curve drawn differential bacterial genera or biomarkers identify accompanied its area under (AUC) 0.85. ROC diagnose AUC 0.97. Conclusion suggested a distinct compared individuals, level CRP. more abundant CRP, might have influenced through

Language: Английский

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Comparison of enteral nutrition methods with weight improvement in patients with T4b esophageal squamous cell carcinoma

Molecular and Clinical Oncology, Journal Year: 2025, Volume and Issue: 22(3)

Published: Jan. 23, 2025

Enteral nutrition is the preferred method for providing to patients who can consume food orally or via a feeding tube. In case of with advanced esophageal cancer, tracking nutritional status critical and weight key factor in this regard. Monitoring changes simple non‑invasive approach that be easily incorporated into clinical settings. Therefore, present study aimed compare different enteral techniques assess efficacy cancer. A retrospective was conducted on squamous cell carcinoma received between January 2012 December 2022, included collection various data, including baseline characteristics, comorbidities, BMI, route nutrition, tolerable total calories per day mode treatment methods such as nasogastric tube (NG), stent, percutaneous endoscopic gastrostomy (PEG) open (OG). The assessed impact body at 0‑, 1‑, 3‑ 6‑month follow‑up, well 1‑year survival. After 3‑month it observed cancer underwent exhibited significant improvement weight. This trended sustained up follow‑up. At 3 months, groups NG, OG PEG optimal results compared stent group (P=0.027, P=0.009 P=0.001, respectively). No differences were among methods. aid suffer from tubes have been demonstrated safe effective options. Within months beginning support, there trend improvement, which could maintained

Language: Английский

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Protocolo diagnóstico y terapéutico de la sarcopenia en los tumores gastrointestinales

Medicine - Programa de Formación Médica Continuada Acreditado, Journal Year: 2025, Volume and Issue: 14(25), P. 1516 - 1520

Published: Feb. 1, 2025

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Relationship of phase angle with postoperative pneumonia and survival prognosis in patients with esophageal cancer: A retrospective cohort study

Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 112743 - 112743

Published: March 1, 2025

Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is an indicator of cell membrane health. Low PhA values reflect poor cellular function and low muscle mass. However, consensus regarding the appropriate cutoff value remains insufficient, its impact on outcomes after esophagectomy in patients with esophageal malignancies not well studied. We aimed to investigate whether preoperative associated postoperative complication risk survival prognosis decrease during surgical preparation period a prognostic factor cancer. This retrospective cohort study analyzed data 194 who had undergone for malignancies. A measured several days before surgery, 5.0° men 4.2° women, was used. The relationship between pneumonia clinicopathological factors investigated. decline were 134 whose twice surgery. Overall, 93 101 classified into high groups, respectively. multivariate showed that serum albumin level lower than 3.5 g/dL independent (odds ratio [OR] = 3.40, P 0.03; OR 3.42, 0.03, respectively). group exhibited significantly higher intraoperative fluid balance (6.7 versus 6.0 mL/kg/h, 0.01) proportion failed achieve early mobilization first day (46 32%, 0.04) did group. Multivariate using Cox proportional hazards model revealed factor, clinical stage cancer (hazard 2.61, < 0.01). In preoperatively, significant 2.59, fewer steps increase (6220 ± 2880 8200 2850, prognosis. factor. Increasing physical activity surgery may lead PhA. Thus, it important measure evaluate changes sequentially

Language: Английский

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Survival predictors of older cancer patients in Bangladesh: A multicenter study

Cancer Epidemiology, Journal Year: 2025, Volume and Issue: 96, P. 102794 - 102794

Published: March 6, 2025

Language: Английский

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Comparison of Effectivity and Safety of Olanzapine and Mirtazapine on Cancer-Associated Anorexia and Cachexia in Advanced Oral Cavity Cancer Patients: Prospective, Comparative, Interventional Study

Journal of Pain & Palliative Care Pharmacotherapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: May 1, 2025

Cancer-associated cachexia-anorexia syndrome (CACS) significantly affects patients' quality of life, leading to weight loss, muscle wasting, and reduced treatment response. This prospective study aimed evaluate effectiveness olanzapine versus mirtazapine in managing CACS. Primary objective was assess their impact on body appetite, while the secondary focused psychological distress sleep. A total 152 patients were randomly allocated into two groups 76 each. Group O received Tablet Olanzapine 5 mg/day orally; M Mirtazapine 15 orally at bed time. All assessed by using Simplified Nutritional Appetite Questionnaire (SNAQ) score time first visit then follow-up 2nd 4th weeks. At week, mean change SNAQ 3.14 compared 2.04 (p = 0.035). By it 3.86 2.87 0.006). Weight changes increased from 45.57 46.81 kg 45.97 46.90 week ≥ 0.5). Both appetite without notable gain. showed stronger effects sleep, anxiety, depression.

Language: Английский

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Mismatch repair-proficient tumor footprints in the sands of immune desert: mechanistic constraints and precision platforms

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 19, 2024

Mismatch repair proficient (MMRp) tumors of colorectal origin are one the prevalent yet unpredictable clinical challenges. Despite earnest efforts, optimal treatment modalities have to emerge for this class. The poor prognosis and limited actionability MMRp ascribed a low neoantigen burden desert-like microenvironment. This review focuses on critical roadblocks orchestrated by an immune evasive mechanistic milieu in context MMRp. density effector cells, their weak spatiotemporal underpinnings, high-handedness IL-17-TGF-β signaling intertwined present formidable challenges existing therapies. Microbiome niche decorated Fusobacterium nucleatum alters metabolic program maintain immunosuppressive state. We also highlight evolving strategies repolarize reinvigorate Reconstruction anti-tumor chemokine signaling, rational drug combinations eliciting T cell activation, reprograming maladapted microbiome exciting developments direction. Alternative vulnerability other DNA damage pathways is gaining momentum. Integration liquid biopsy ex vivo functional platforms provide precision oncology insights. illustrated perspectives changing landscape MMRp-CRC. emerging opportunities discussed can turn tide favor fighting dilemma elusive cancer.

Language: Английский

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Cancer knocks you out by fasting: Cachexia as a consequence of metabolic alterations in cancer

Journal of Cellular Physiology, Journal Year: 2024, Volume and Issue: 240(1)

Published: Sept. 8, 2024

Neoplastic transformation reprograms tumor and surrounding host cell metabolism, increasing nutrient consumption depletion in the microenvironment. Tumors uptake nutrients from neighboring normal tissues or bloodstream to meet energy anabolic demands. Tumor-induced chronic inflammation, a high-energy process, also consumes sustain its dysfunctional activities. These tumor-related metabolic physiological changes, including negatively impact systemic metabolism physiology. Furthermore, adverse effects of antitumor therapy obstruction impair endocrine, neural, gastrointestinal systems, thereby confounding status patients. alterations result decreased appetite, impaired absorption, shift catabolic metabolism. Consequently, cancer patients often suffer malnutrition, which worsens prognosis increases susceptibility secondary events. This review explores how neoplastic affects microenvironment leading poor prognosis, discusses potential strategies clinical interventions improve patient outcomes.

Language: Английский

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Nisin A elevates adenosine to achieve anti-inflammatory activity

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This study uncovers that nisin A achieves excellent anti-inflammatory activity via enhancing the level of adenosine, followed by up-regulation sphingolipid signaling pathway and down-regulation purine metabolism.

Language: Английский

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Mechanisms of cancer cachexia and targeted therapeutic strategies

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189208 - 189208

Published: Nov. 1, 2024

Language: Английский

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