Effect of early enteral nutrition on postoperative outcomes in pancreatic cancer patients with diabetes.

Investigación Clínica, Journal Year: 2025, Volume and Issue: 66(1), P. 89 - 100

Published: March 7, 2025

This study aimed to evaluate the impact of early enteral nutri-tion support in pancreatic cancer patients with diabetes mellitus following to-tal pancreatectomy. Ninety-six were randomly divided into control and research groups, each 48 patients. Both groups received parenteral nutri-tion, while group additional nutrition within first hours post-surgery. Results showed that experienced faster recovery bowel sounds, earlier defecation, shorter gastric tube retention times compared (p<0.05). Postoperative gastrointestinal function, immune nutritional status signifi-cantly better group, higher levels gastrin, motilin, im-munoglobulins G, A, M, CD4/CD8 ratio, albumin, prealbumin, trans-ferrin Furthermore, had blood glucose from seven days post-surgery The above results demonstrated a promoting on postoperative physical functioning melli-tus. In conclusion, significantly improved status, recovery, glu-cose control, leading overall prognosis.

Language: Английский

ZIP4: a promising early diagnostic and therapeutic targets for pancreatic cancer

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(9), P. 4652 - 4664

Published: Jan. 1, 2024

Pancreatic cancer is an aggressive and metastatic tumor that lacks effective early detection treatment methods. There urgent need to further understand its underlying molecular mechanisms identify new biomarkers for detection. Zinc, a critical trace element catalytic cofactor, tightly regulated within cells. ZIP4, zinc transporter protein significantly overexpressed in human pancreatic cancer, appears play pivotal role development by modulating intracellular concentration. This review highlights the of ZIP4 tumorigenesis, including impact on growth, proliferation, migration, drug resistance. exerts effects regulating dependent transcriptional factors like CREB, STAT3, ZEB1, resulting upregulation Cyclin D1, TP53INP1, ITGA3, CD44, ENT1 proteins, miR-373. Moreover, mediates miR373-PHLPP2-AKT signaling axis, which increases TGF-β expression. Coupled with CREB-activated macrophage catabolism-related genes SDC1 DNM2, promotes cachexia supports amino acids cells under metabolic stress. Furthermore, facilitates bone resorption osteoclasts via RANKL-activated NF-κB pathway. A deeper understanding these may unveil potential targets diagnosis, prognosis assessment, dietary recommendations cancer. These findings hold clinical significance not only but also other malignancies exhibiting heightened

Language: Английский