Mitochondria-Derived Vesicles and Inflammatory Profiles of Adults with Long COVID Supplemented with Red Beetroot Juice: Secondary Analysis of a Randomized Controlled Trial
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1224 - 1224
Published: Jan. 30, 2025
In
a
recent
clinical
trial,
beetroot
juice
supplementation
for
14
days
yielded
positive
effects
on
systemic
inflammation
in
adults
with
long
COVID.
Here,
we
explored
the
relationship
between
circulating
markers
of
mitochondrial
quality
and
COVID
as
well
impact
administration
those
markers.
We
conducted
secondary
analyses
placebo-controlled
randomized
trial
testing
remedy
against
Analyses
were
25
participants,
10
assigned
to
placebo
(mean
age:
40.2
±
11.5
years,
60%
women)
15
allocated
38.3
7.7
53.3%
women).
Extracellular
vesicles
purified
from
serum
by
ultracentrifugation
assayed
components
electron
transport
chain
DNA
(mtDNA)
Western
blot
droplet
digital
polymerase
reaction
(ddPCR),
respectively.
Inflammatory
cell-free
mtDNA
quantified
through
multiplex
immunoassay
ddPCR,
Beetroot
decreased
levels
interleukin
(IL)-1β,
IL-8,
tumor
necrosis
factor
alpha,
no
control.
Significant
negative
associations
observed
vesicular
control
performance
6
min
walk
test
flow-mediated
dilation
irrespective
group
allocation.
These
findings
suggest
that
an
amelioration
quality,
possibly
mediated
mitochondria-derived
vesicle
recycling,
may
be
among
mechanisms
supporting
improvements
physical
endothelial
function
during
resolution
Language: Английский
Reply - Letter to the editor - ‘Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with Long COVID"
Clinical Nutrition,
Journal Year:
2025,
Volume and Issue:
46, P. 133 - 135
Published: Feb. 1, 2025
Language: Английский
Variability in Arterial Stiffness and Vascular Endothelial Function After COVID-19 During 1.5 Years of Follow-Up—Systematic Review and Meta-Analysis
Life,
Journal Year:
2025,
Volume and Issue:
15(4), P. 520 - 520
Published: March 21, 2025
Increasing
long-term
observations
suggest
that
coronavirus
disease
2019
(COVID-19)
vasculopathy
may
persist
even
1.5
years
after
the
acute
phase,
potentially
accelerating
development
of
atherosclerotic
cardiovascular
diseases.
This
study
systematically
reviewed
variability
brachial
flow-mediated
dilation
(FMD)
and
carotid-femoral
pulse
wave
velocity
(cfPWV)
from
phase
COVID-19
through
16
months
follow-up
(F/U).
Databases
including
PubMed,
Web
Science,
MEDLINE,
Embase
were
screened
for
a
meta-analysis
without
language
or
date
restrictions
(PROSPERO
reference
CRD42025642888,
last
search
conducted
on
1
February
2025).
The
quality
included
studies
was
assessed
using
Newcastle–Ottawa
Quality
Scale.
We
considered
all
(interventional
pre-post
studies,
prospective
observational
randomized,
non-randomized
trials)
FMD
cfPWV
in
adults
(aged
≥
18
years)
with
laboratory-confirmed
compared
non-COVID-19
controls
changes
these
parameters
during
F/U.
Twenty-one
reported
differences
FMD,
examined
between
patients
control
groups
various
stages:
acute/subacute
(≤30
days
onset),
early
(>30–90
days),
mid-term
(>90–180
late
(>180–270
very
(>270
days)
post-COVID-19
recovery.
Six
while
nine
did
so
Data
14
(627
cases
694
controls)
15
(578
703
our
meta-analysis.
showed
significant
decrease
to
(standardized
mean
difference
[SMD]=
−2.02,
p
<
0.001),
partial
improvements
noted
recovery
(SMD
=
0.95,
0.001)
0.92,
0.006).
Normalization
observed
0.12,
0.69).
In
contrast,
values,
which
higher
than
1.27,
remained
elevated
throughout
F/U,
no
except
(SMD=
−0.39,
0.001).
recovery,
values
those
0.45,
0.010).
manuscript,
we
discuss
how
factors,
severity
COVID-19,
persistence
syndrome,
patient’s
initial
vascular
age,
depending
metrics
age
risk
influenced
time
degree
improvement.
Language: Английский