Fetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Prospective Multicenter Cohort Study in Portugal
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(1), P. 110 - 110
Published: Jan. 6, 2025
Background/Objectives:
Retinopathy
of
prematurity
(ROP)
is
a
leading
cause
vision
impairment
in
preterm
infants,
with
its
pathogenesis
linked
to
oxygen
exposure.
Red
blood
cell
(RBC)
transfusions,
commonly
performed
neonatal
intensive
care
units
(NICUs),
reduce
fetal
hemoglobin
(HbF)
fraction,
altering
dynamics
and
potentially
contributing
ROP.
We
aimed
investigate
the
relationship
between
RBC
HbF
percentage,
ROP,
evaluating
as
potential
predictive
biomarker.
Methods:
A
multicenter,
prospective
study
was
conducted
across
eight
Portuguese
NICUs,
involving
infants
born
at
<32
weeks
gestational
age
(GA)
or
<1500
g.
ROP
staging
followed
International
Classification
(ICROP2).
Clinical
data
were
collected
during
hospitalization,
fractions
measured
from
samples
first
four
life
using
standardized
methods.
Infants
stratified
by
presence
treatment
requirement.
Statistical
analysis
SPSS
28.0,
p
<
0.05.
Results:
Eighty-two
(mean
GA:
28.1
±
2.1
weeks,
birth
weight:
1055.8
258.3
g)
included.
Among
them,
29
(35.4%)
presented
4
(4.9%)
required
treatment.
had
more
transfusions
lower
percentages
than
those
without
(p
0.05).
Lower
associated
0.001).
Kaplan–Meier
survival
curves
showed
higher
risk
reduced
Conclusions:
Low
percentage
may
increase
infants.
could
serve
biomarker
for
prediction.
Interventions
preserving
risk.
Further
studies
are
needed
validate
refine
prevention
strategies.
Language: Английский
Bridging the evidence-to-practice gap: Advancing neonatal blood transfusion. A narrative review of recent guidelines
Blood Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101282 - 101282
Published: March 1, 2025
Language: Английский
The number of blood transfusions received and the incidence and severity of chronic lung disease among NICU patients born >31 weeks gestation
Journal of Perinatology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 15, 2024
Language: Английский
Banked term umbilical cord blood to meet the packed red blood cell transfusion needs of extremely-low-gestational-age neonates: a feasibility analysis
Journal of Perinatology,
Journal Year:
2023,
Volume and Issue:
44(6), P. 873 - 879
Published: Nov. 29, 2023
Language: Английский
Development of molecular sterility assay for rapid quality release of cord blood erythrocytes units for transfusion
Transfusion,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Abstract
Background
Umbilical
cord
blood
(CB)
units
stored
in
banks
are
an
important
source
of
hematopoietic
stem
cells
for
transplantation
and
other
cell
therapies.
New
applications,
such
as
their
use
transfusions,
require
rapid
quality
release
red
(CB‐RBC)
have
a
shorter
shelf
life.
Study
Design
Methods
This
project
aims
to
investigate
the
most
prevalent
microbial
contaminants
CB
preparations
validate
sterility
testing
strategy
CB‐RBC
based
on
automated
system
(BACT/ALERT®)
tandem
with
molecular
assay
(real‐time
PCR)
capable
detecting
at
least
100
CFU/mL
Cutibacterium
acnes
accelerate
detection
common
slow‐growing
bacteria.
Results
Microbial
contamination
incidence
was
assessed
by
reviewing
4696
tests,
revealing
positivity
rate
3.4%,
C.
being
pathogen.
The
BACT/ALERT®
system,
which
validated
according
European
Pharmacopeia
guidelines,
appropriate
method
CB‐RBC,
although
it
required
up
14
days
culture
detect
when
iFAPlus
iFNPlus
bottles
were
used
neutralize
antimicrobials.
Interestingly,
detected
30
within
days,
while
real‐time
PCR
identified
concentrations
≥65
Day
4.
Discussion
In
conclusion,
we
developed
that
combines
systems
early
contamination,
enhancing
life
transfusion
emphasizing
importance
combining
methods.
Language: Английский
Oxygen affinity of fetal and adult hemoglobin in action: shifting our understanding of red blood cell transfusions in neonates
Pediatric Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Language: Английский
Banked term umbilical cord blood to meet the packed red blood cell transfusion needs of extremely-low-gestational-age neonates: A feasibility analysis
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 6, 2023
Abstract
OBJECTIVES:
To
assess
the
feasibility
of
drawing,
processing,
safety-testing,
and
banking
term
umbilical
cord
blood
to
meet
packed
red
cell
transfusion
(RBC
Tx)
needs
extremely-low-gestational-age
neonates
(ELGANs).
DESIGN:
1)
Retrospectively
analyze
all
ELGANs
RBC
Tx
over
past
three
years,
2)
Estimate
local
availability,
3)
Assess
interest
in
this
project,
implementation
barriers,
through
stakeholder
surveys.
RESULTS:
In
years
we
cared
for
266
ELGANs;
165
(62%)
received
≥1
Tx.
Annual
averaged
197
(95%
CI,
152
-
243).
If
10%
our
10,353
annual
births
had
drawn
processed,
half
those
tested
were
acceptable
Tx,
collections
would
exceed
95
th
%
upper
estimate
need
by
>four-fold.
Interest
exceeded
97%.
Identified
barriers
included
FDA
approval,
training
collect
blood,
cost.
CONCLUSION:
ELGANS
could
be
met
collection.
Language: Английский