Patient-specific coronary angioplasty simulations — A mixed-dimensional finite element modeling approach
Computers in Biology and Medicine,
Journal Year:
2025,
Volume and Issue:
189, P. 109914 - 109914
Published: March 10, 2025
Coronary
angioplasty
with
stent
implantation
is
the
most
frequently
used
interventional
treatment
for
coronary
artery
disease.
However,
reocclusion
within
stent,
referred
to
as
in-stent
restenosis,
occurs
in
up
10%
of
lesions.
It
widely
accepted
that
mechanical
loads
on
vessel
wall
strongly
affect
adaptive
and
maladaptive
mechanisms.
Yet,
role
procedural
lesion-specific
influence
restenosis
risk
remains
understudied.
Computational
modeling
stenting
procedure
can
provide
new
mechanistic
insights,
such
local
stresses,
play
a
significant
tissue
growth
remodeling.
Previous
simulation
studies
often
featured
simplified
geometries
cannot
be
applied
real-world
examples.
Realistic
simulations
were
computationally
expensive
since
they
fully
resolved
device
models.
The
aim
this
work
develop
present
mixed-dimensional
formulation
simulate
patient-specific
reduced-dimensional
beam
model
3D
models
artery.
In
addition
presenting
numerical
approach,
we
apply
it
realistic
cases
study
intervention's
effect
correlate
findings
potential
high-risk
locations
restenosis.
We
found
high
stresses
during
intervention
severely
stenosed
areas
at
boundaries.
Herewith,
lay
groundwork
further
towards
preventing
after
angioplasty.
Language: Английский
Incremental deformations and bifurcation of elastic solids reinforced by fibers with intrinsic extensional, flexural, and torsional elasticity
Journal of Applied Mechanics,
Journal Year:
2024,
Volume and Issue:
92(1)
Published: Nov. 14, 2024
Abstract
We
present
a
model
for
incremental
deformations
of
an
elastic
solid
reinforced
by
single
family
fibers
that
offer
resistance
to
extension,
flexure,
and
torsion.
The
theory
is
cast
in
the
setting
small-on-large
provides
framework
multiscale
analysis
bifurcation
equilibria
fibrous
composites.
based
on
three-dimensional
Cosserat
elasticity
which
fiber
kinematics
are
controlled
rotation
field
weakly
coupled
bulk
deformation
through
pointwise
fiber-materiality
constraint.
Fiber–matrix
interaction
forces
explicitly
accounted
via
attendant
Lagrange
multipliers.
demonstrate
utility
investigating
onset
incompressible
fiber-reinforced
half-plane.
In
particular,
we
study
influence
axial
stiffness,
flexural
fiber–matrix
planar
buckling
modes.
envisage
problems
biological
industrial
relevance
with
view
gaining
better
insight
into
roles
bending,
twisting,
regulating
Language: Английский