The interplay between cell signalling and the mevalonate pathway in cancer

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(11), P. 718 - 731

Published: Aug. 26, 2016

Language: Английский

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New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

Redox Biology, Journal Year: 2018, Volume and Issue: 20, P. 247 - 260

Published: Oct. 20, 2018

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis. Intracellular hyperglycemia promotes production mitochondrial reactive oxygen species (ROS), increased formation intracellular advanced glycation end-products, activation protein kinase C, polyol pathway flux. ROS directly increase expression inflammatory adhesion factors, oxidized-low density lipoprotein, insulin resistance. They activate ubiquitin pathway, inhibit AMP-protein adiponectin, decrease endothelial nitric oxide synthase activity, all which accelerate Changes composition gut microbiota changes microRNA that influence regulation target genes occur diabetes with to promote This review highlights consequences sustained acceleration atherosclerosis by diabetes. The potential contributions are discussed.

Language: Английский

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AMPK as a Therapeutic Target for Treating Metabolic Diseases

Trends in Endocrinology and Metabolism, Journal Year: 2017, Volume and Issue: 28(8), P. 545 - 560

Published: June 21, 2017

Language: Английский

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New insights into activation and function of the AMPK

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(4), P. 255 - 272

Published: Oct. 31, 2022

Language: Английский

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Expanding Roles for SREBP in Metabolism

Cell Metabolism, Journal Year: 2012, Volume and Issue: 16(4), P. 414 - 419

Published: Sept. 20, 2012

Language: Английский

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