PPARγ signaling and metabolism: the good, the bad and the future

Nature Medicine, Journal Year: 2013, Volume and Issue: 19(5), P. 557 - 566

Published: May 1, 2013

Language: Английский

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Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

Cell Metabolism, Journal Year: 2012, Volume and Issue: 16(2), P. 153 - 166

Published: July 17, 2012

Language: Английский

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Adipose tissue browning and metabolic health

Nature Reviews Endocrinology, Journal Year: 2013, Volume and Issue: 10(1), P. 24 - 36

Published: Oct. 22, 2013

Language: Английский

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Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

Nature Immunology, Journal Year: 2014, Volume and Issue: 15(9), P. 846 - 855

Published: Aug. 3, 2014

Language: Английский

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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Nature Communications, Journal Year: 2015, Volume and Issue: 6(1)

Published: March 26, 2015

During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty β-oxidation (FAO). promotes FAO endogenous lipids by increasing expression CPT1A, and inducing lipolysis as indicated elevation the lipase ATGL, marker glycerol release acids. Conversely, CTLA-4 inhibits without augmenting FAO, suggesting sustains profile non-activated cells. Because utilize during differentiation effectors, our findings reveal a mechanism responsible for PD-1-mediated blockade T-effector cell differentiation. The enhancement provides mechanistic explanation longevity receiving signals patients with chronic infections cancer, their capacity be reinvigorated blockade.

Language: Английский

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Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

Developmental Cell, Journal Year: 2015, Volume and Issue: 32(6), P. 678 - 692

Published: March 1, 2015

Language: Английский

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Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

Immunity, Journal Year: 2014, Volume and Issue: 41(1), P. 75 - 88

Published: July 1, 2014

Language: Английский

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Emerging roles of lipid metabolism in cancer metastasis

Molecular Cancer, Journal Year: 2017, Volume and Issue: 16(1)

Published: April 11, 2017

Cancer cells frequently display fundamentally altered cellular metabolism, which provides the biochemical foundation and directly contributes to tumorigenicity malignancy. Rewiring of metabolic programmes, such as aerobic glycolysis increased glutamine are crucial for cancer shed from a primary tumor, overcome nutrient energy deficit, eventually survive form metastases. However, role lipid metabolism that confers aggressive properties malignant cancers remains obscure. The present review is focused on key enzymes in associated with metastatic disease pathogenesis. We also address function an important membrane structure-lipid raft mediating tumor progression. enumerate integrate these recent findings into our current understanding reprogramming metastasis accompanied by new exciting therapeutic implications.

Language: Английский

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Immobilization of lipases on hydrophobic supports: immobilization mechanism, advantages, problems, and solutions

Biotechnology Advances, Journal Year: 2019, Volume and Issue: 37(5), P. 746 - 770

Published: April 8, 2019

Language: Английский

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Novozym 435: the “perfect” lipase immobilized biocatalyst?

Catalysis Science & Technology, Journal Year: 2019, Volume and Issue: 9(10), P. 2380 - 2420

Published: Jan. 1, 2019

Novozym 435 (N435) is a commercially available immobilized lipase produced by Novozymes with its advantages and drawbacks.

Language: Английский

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