Oxidative Stress in Cancer

Cancer Cell, Journal Year: 2020, Volume and Issue: 38(2), P. 167 - 197

Published: July 9, 2020

Language: Английский

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The multifaceted contributions of mitochondria to cellular metabolism

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(7), P. 745 - 754

Published: June 22, 2018

Language: Английский

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Gut microbial metabolites as multi-kingdom intermediates

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(2), P. 77 - 94

Published: Sept. 23, 2020

Language: Английский

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Circadian physiology of metabolism

Science, Journal Year: 2016, Volume and Issue: 354(6315), P. 1008 - 1015

Published: Nov. 24, 2016

A majority of mammalian genes exhibit daily fluctuations in expression levels, making circadian rhythms the largest known regulatory network normal physiology. Cell-autonomous clocks interact with light-dark and feeding-fasting cycles to generate approximately 24-hour oscillations function thousands genes. Circadian secreted molecules signaling components transmits timing information between cells tissues. Such intra- intercellular optimize physiology both by managing energy use temporally segregating incompatible processes. Experimental animal models epidemiological data indicate that chronic rhythm disruption increases risk metabolic diseases. Conversely, time-restricted feeding, which imposes feeding fasting without caloric reduction, sustains robust diurnal can alleviate These findings highlight an integrative role offer a new perspective for treating diseases is hallmark.

Language: Английский

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Metabolic regulation of cell growth and proliferation

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(7), P. 436 - 450

Published: April 11, 2019

Language: Английский

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Targeting cancer metabolism in the era of precision oncology

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 21(2), P. 141 - 162

Published: Dec. 3, 2021

Language: Английский

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Epigenetics in Human Obesity and Type 2 Diabetes

Cell Metabolism, Journal Year: 2019, Volume and Issue: 29(5), P. 1028 - 1044

Published: April 11, 2019

Epigenetic mechanisms control gene activity and the development of an organism. The epigenome includes DNA methylation, histone modifications, RNA-mediated processes, disruption this balance may cause several pathologies contribute to obesity type 2 diabetes (T2D). This Review summarizes epigenetic signatures obtained from human tissues relevance for metabolism-i.e., adipose tissue, skeletal muscle, pancreatic islets, liver, blood-in relation T2D. Although research field is still young, these comprehensive data support not only a role epigenetics in disease development, but also alterations as response disease. Genetic predisposition, well aging, variability, environmental factors, including exercise diet, further interact with epigenome. reversible nature modifications holds promise future therapeutic strategies

Language: Английский

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Amino acids in cancer

Experimental & Molecular Medicine, Journal Year: 2020, Volume and Issue: 52(1), P. 15 - 30

Published: Jan. 1, 2020

Abstract Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one the first distinguishing characteristics cancer 1 . The field metabolism subsequently revealed additional alterations in by focusing on central carbon metabolism, including citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon contributions to cell viability growth. Amino acids, nutrients vital survival all types, experience reprogrammed cancer. This review outlines diverse roles amino acids within tumor microenvironment. Beyond their role biosynthesis, they serve energy sources help maintain redox balance. In addition, derivatives contribute epigenetic regulation immune responses linked tumorigenesis metastasis. Furthermore, discussing transporters transaminases that mediate uptake synthesis, we identify potential liabilities targets for therapeutic intervention.

Language: Английский

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The expanding world of tRNA modifications and their disease relevance

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(6), P. 375 - 392

Published: March 3, 2021

Language: Английский

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Mitochondrial diseases: the contribution of organelle stress responses to pathology

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 19(2), P. 77 - 92

Published: Aug. 9, 2017

Language: Английский

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