The FASEB Journal,
Journal Year:
2019,
Volume and Issue:
34(2), P. 2213 - 2226
Published: Dec. 12, 2019
Transforming
growth
factor-beta
(TGFβ)
is
an
enigmatic
protein
with
various
roles
in
healthy
tissue
homeostasis/development
as
well
the
development
or
progression
of
cancer,
wound
healing,
fibrotic
disorders,
and
immune
modulation,
to
name
a
few.
As
TGFβ
causal
fibroproliferative
disorders
featuring
localized
systemic
tissue/organ
fibrosis
activated
stroma
observed
malignancies,
characterizing
pathways
players
mediating
its
action
fundamental.
In
current
study,
we
found
that
induces
expression
immunoinhibitory
molecule
Programed
death-ligand
1
(PD-L1)
human
murine
fibroblasts
Smad2/3-
YAP/TAZ-dependent
manner.
Furthermore,
PD-L1
knockdown
decreased
TGFβ-dependent
induction
extracellular
matrix
proteins,
including
collagen
Iα1
(colIα1)
alpha-smooth
muscle
actin
(α-SMA),
cell
migration/wound
healing.
addition
endogenous
role
for
profibrotic
signaling,
stimulated-human
lung
fibroblast-derived
into
vesicles
(EVs)
capable
inhibiting
T
proliferation
response
receptor
stimulation
fibroblast
migration.
These
findings
provide
new
insights
potential
targets
variety
malignant
diseases.
Cells,
Journal Year:
2020,
Volume and Issue:
9(4), P. 1055 - 1055
Published: April 23, 2020
Helicobacter
pylori
(H.
pylori)
is
one
of
the
most
common
human
pathogens,
affecting
half
world’s
population.
Approximately
20%
infected
patients
develop
gastric
ulcers
or
neoplastic
changes
in
stroma.
An
infection
also
leads
to
progression
epithelial–mesenchymal
transition
within
tissue,
increasing
probability
cancer
development.
This
paper
aims
review
role
H.
and
its
virulence
factors
associated
with
malignant
transformation
The
reviewed
included:
CagA
(cytotoxin-associated
gene
A)
along
induction
stem-cell
properties
interaction
YAP
(Yes-associated
protein
pathway),
tumor
necrosis
factor
α-inducing
protein,
Lpp20
lipoprotein,
Afadin
penicillin-binding
1A,
microRNA-29a-3p,
programmed
cell
death
4,
lysosomal-associated
transmembrane
4β,
cancer-associated
fibroblasts,
heparin-binding
epidermal
growth
(HB-EGF),
matrix
metalloproteinase-7
(MMP-7),
stem
cells
(CSCs).
summarizes
recent
findings,
providing
insight
into
potential
molecular
targets
new
treatment
strategies
for
cancer.
The Journal of Experimental Medicine,
Journal Year:
2020,
Volume and Issue:
217(8)
Published: June 2, 2020
Upon
immunogenic
challenge,
lymph
nodes
become
mechanically
stiff
as
immune
cells
activate
and
proliferate
within
their
encapsulated
environments,
with
resolution,
they
reestablish
a
soft
baseline
state.
Here
we
show
that
sensing
these
mechanical
changes
in
the
microenvironment
requires
mechanosensor
YAP.
YAP
is
induced
upon
activation
suppresses
metabolic
reprogramming
of
effector
T
cells.
Unlike
other
cell
types
which
promotes
proliferation,
proliferation
stiffness-dependent
manner
by
directly
restricting
translocation
NFAT1
into
nucleus.
slows
responses
systemic
viral
infections
retards
autoimmune
diabetes.
Our
work
reveals
paradigm
whereby
tissue
mechanics
fine-tune
adaptive
health
disease.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(19), P. 7430 - 7430
Published: Oct. 8, 2020
Helicobacter
pylori
causes
persistent
infection
in
the
gastric
epithelium
of
more
than
half
world’s
population,
leading
to
development
severe
complications
such
as
peptic
ulcer
diseases,
cancer,
and
mucosa-associated
lymphoid
tissue
(MALT)
lymphoma.
Several
virulence
factors,
including
cytotoxin-associated
gene
A
(CagA),
which
is
translocated
into
via
type
4
secretory
system
(T4SS),
have
been
indicated
play
a
vital
role
disease
development.
Although
with
strains
harboring
East
Asian
CagA
possessing
EPIYA-A,
-B,
-D
sequences
has
found
potentiate
cell
proliferation
pathogenicity,
exact
mechanism
involvement
severity
still
remains
be
elucidated.
Therefore,
we
discuss
possible
pathogenicity.
Cells,
Journal Year:
2019,
Volume and Issue:
8(5), P. 426 - 426
Published: May 8, 2019
The
Hippo
signaling
pathway
is
involved
in
tissue
size
regulation
and
tumorigenesis.
Genetic
deletion
or
aberrant
expression
of
some
genes
lead
to
enhanced
cell
proliferation,
tumorigenesis,
cancer
metastasis.
Recently,
multiple
studies
have
identified
a
wide
range
upstream
regulators
the
pathway,
including
mechanical
cues
ligands
G
protein-coupled
receptors
(GPCRs).
Through
activation
related
proteins
possibly
rearrangements
actin
cytoskeleton,
GPCR
can
potently
modulate
phosphorylation
states
activity
YAP
TAZ,
two
homologous
oncogenic
transcriptional
co-activators,
major
effectors
pathway.
Herein,
we
summarize
network,
regulation,
functions
GPCR-Hippo
signaling,
will
also
discuss
potential
anti-cancer
therapies
targeting
GPCR-YAP
signaling.
The FASEB Journal,
Journal Year:
2019,
Volume and Issue:
34(2), P. 2213 - 2226
Published: Dec. 12, 2019
Transforming
growth
factor-beta
(TGFβ)
is
an
enigmatic
protein
with
various
roles
in
healthy
tissue
homeostasis/development
as
well
the
development
or
progression
of
cancer,
wound
healing,
fibrotic
disorders,
and
immune
modulation,
to
name
a
few.
As
TGFβ
causal
fibroproliferative
disorders
featuring
localized
systemic
tissue/organ
fibrosis
activated
stroma
observed
malignancies,
characterizing
pathways
players
mediating
its
action
fundamental.
In
current
study,
we
found
that
induces
expression
immunoinhibitory
molecule
Programed
death-ligand
1
(PD-L1)
human
murine
fibroblasts
Smad2/3-
YAP/TAZ-dependent
manner.
Furthermore,
PD-L1
knockdown
decreased
TGFβ-dependent
induction
extracellular
matrix
proteins,
including
collagen
Iα1
(colIα1)
alpha-smooth
muscle
actin
(α-SMA),
cell
migration/wound
healing.
addition
endogenous
role
for
profibrotic
signaling,
stimulated-human
lung
fibroblast-derived
into
vesicles
(EVs)
capable
inhibiting
T
proliferation
response
receptor
stimulation
fibroblast
migration.
These
findings
provide
new
insights
potential
targets
variety
malignant
diseases.
