Phenotypic diversity and metabolic specialization of renal endothelial cells

Nature Reviews Nephrology, Journal Year: 2021, Volume and Issue: 17(7), P. 441 - 464

Published: March 25, 2021

Language: Английский

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Control of endothelial quiescence by FOXO-regulated metabolites

Nature Cell Biology, Journal Year: 2021, Volume and Issue: 23(4), P. 413 - 423

Published: April 1, 2021

Endothelial cells (ECs) adapt their metabolism to enable the growth of new blood vessels, but little is known how ECs regulate adopt a quiescent state. Here, we show that metabolite S-2-hydroxyglutarate (S-2HG) plays crucial role in regulation endothelial quiescence. We find S-2HG produced after activation transcription factor forkhead box O1 (FOXO1), where it limits cell cycle progression, metabolic activity and vascular expansion. FOXO1 stimulates production by inhibiting mitochondrial enzyme 2-oxoglutarate dehydrogenase. This inhibition relies on branched-chain amino acid catabolites such as 3-methyl-2-oxovalerate, which increase with activated FOXO1. Treatment 3-methyl-2-oxovalerate elicits suppresses proliferation, causing rarefaction mice. Our findings identify programme promotes acquisition state highlight metabolites signalling molecules endothelium.

Language: Английский

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Endocrine role of bone in the regulation of energy metabolism

Bone Research, Journal Year: 2021, Volume and Issue: 9(1)

Published: May 20, 2021

Abstracts Bone mainly functions as a supportive framework for the whole body and is major regulator of calcium homeostasis hematopoietic function. Recently, an increasing number studies have characterized significance bone endocrine organ, suggesting that bone-derived factors regulate local metabolism metabolic functions. In addition, these can global energy by altering insulin sensitivity, feeding behavior, adipocyte commitment. These findings may provide new pathological mechanism related diseases or be used in diagnosis, treatment, prevention such osteoporosis, obesity, diabetes mellitus. this review, we summarize regulatory effect on discuss directions future research.

Language: Английский

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Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation

Molecular Cell, Journal Year: 2020, Volume and Issue: 80(1), P. 43 - 58.e7

Published: Sept. 15, 2020

Language: Английский

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Metabolic Regulation of Cell Fate and Function

Trends in Cell Biology, Journal Year: 2020, Volume and Issue: 30(3), P. 201 - 212

Published: Jan. 23, 2020

Language: Английский

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