Effects of combustible cigarettes and electronic nicotine delivery systems on immune cell‐driven inflammation: Evidences from diabetic patients and multiple low dose streptozotocin‐treated diabetic mice DOI
Nikolina Kastratović, Aleksandar Arsenijević,

Carl Randall Harrell

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(9)

Published: Sept. 1, 2024

Considering detrimental impacts of combustible cigarettes (CCs) on the exacerbation diabetes mellitus (DM), a significant number DM patients have substituted CCs with electronic nicotine delivery systems (ENDS). Herewith, we compared and ENDS-dependent modulation immune cell-driven inflammation in who used ENDS (DM

Language: Английский

Regulatory T cells and immune escape in HCC: understanding the tumor microenvironment and advancing CAR-T cell therapy DOI Creative Commons

Guangtan Du,

Cunmiao Dou,

Peng Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 29, 2024

Liver cancer, which most commonly manifests as hepatocellular carcinoma (HCC), is the sixth common cancer in world. In HCC, immune system plays a crucial role growth and proliferation of tumor cells. HCC achieve escape through microenvironment, significantly promotes development this cancer. Here, article introduces summarizes functions effects regulatory T cells (Tregs) highlighting how Tregs inhibit regulate cells, cytokines, ligands receptors, etc, thereby promoting escape. addition, it discusses mechanism CAR-T therapy for elaborate on relationship between Tregs.

Language: Английский

Citations

11
Adoptive Treg therapy using chitosan conduits/self-assembled peptide hydrogels for enhanced immunomodulation and peripheral nerve regeneration DOI
Yuan Feng,

Xiaomin Yao,

Yuyang Ma

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159812 - 159812

Published: Jan. 1, 2025

Language: Английский

Citations

1
Subcutaneous adipose tissue: Implications in dermatological diseases and beyond DOI Creative Commons
Reihane Ziadlou, Ganesh N. Pandian, Jürg Hafner

et al.

Allergy, Journal Year: 2024, Volume and Issue: 79(12), P. 3310 - 3325

Published: Aug. 29, 2024

Abstract Subcutaneous adipose tissue (SAT) is the deepest component of three‐layered cutaneous integument. While mesenteric tissue‐based immune processes have gained recognition in context metabolic syndrome, SAT has been traditionally considered primarily for energy storage, with less attention to its functions. harbors a reservoir and stromal cells that significantly impact immunologic not only skin, but even on systemic level. These include wound healing, infections, immunometabolic, autoimmune diseases, inflammatory skin as well neoplastic conditions. A better understanding functions different processes, could open avenues novel therapeutic interventions. Targeting may address SAT‐specific diseases also offer potential treatments or This review aims provide comprehensive overview SAT's structure functions, highlight recent advancements role both homeostatic pathological conditions within beyond discuss main questions future research field.

Language: Английский

Citations

3
Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments DOI Creative Commons
Maike Becker,

Stefanie Kälin,

Anne H. Neubig

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 20, 2025

Abstract The hypothalamus in the central nervous system (CNS) has important functions controlling systemic metabolism. A calorie-rich diet triggers CNS immune activation, impairing metabolic control and promoting obesity Type 2 Diabetes (T2D), but mechanisms driving hypothalamic activation remain unclear. Here we identify regulatory T cells (Tregs) as key modulators of responses. In mice, environments activate CD4 + cells, infiltrating macrophages microglia while reducing Tregs. mRNA profiling reveals a Th1-like state, with increased Tbx21 , Cxcr3 Cd226 decreased Ccr7 S1pr1 . Importantly, results from Treg loss-of function gain-of-function experiments show that Tregs limit reverse impairments induced by hyper-caloric feeding. Our findings thus help refine current model Treg-centered immune-metabolic crosstalk brain may contribute to development precision modulation for diabetes.

Language: Английский

Citations

0
Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic disease DOI Creative Commons
Wan Chen, Meiling Li, Guang‐Zhi Zeng

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107794 - 107794

Published: May 1, 2025

Language: Английский

Citations

0
Subcutaneous Adipose Tissue: Implications in Dermatological Diseases and Beyond DOI Open Access
Reihane Ziadlou, Ganesh N. Pandian, Jürg Hafner

et al.

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: March 25, 2024

Subcutaneous adipose tissue (SAT) is the deepest component of three-layered cutaneous integument. While mesenteric tissue-based immune processes have gained recognition in context metabolic syndrome, SAT has been traditionally considered primarily for energy storage, with less attention to its functions. harbors a reservoir and stromal cells that significantly impact immunologic not only skin, but even on systemic level. These include wound healing, infections, immunometabolic autoimmune diseases, inflammatory skin as well neoplastic conditions. A better understanding functions different processes, could open avenues novel therapeutic interventions. Targeting may address SAT-specific diseases also offer potential treatments or This review aims provide comprehensive overview SAT’s structure functions, highlight recent advancements role both homeostatic pathological conditions within beyond discuss main questions future research field.

Language: Английский

Citations

0
[Latest Findings on the Role of α-Ketoglutarate in Metabolic Syndrome]. DOI
Yuhan Li,

Yuan Wang,

Quan Yuan

et al.

PubMed, Journal Year: 2024, Volume and Issue: 55(3), P. 783 - 792

Published: May 20, 2024

Alpha-ketoglutarate (α-KG), an endogenous intermediate of the tricarboxylic acid cycle, is involved in a variety cellular metabolic pathways. It serves as energy donor, precursor amino biosynthesis, and epigenetic regulator. α-KG plays physiological functions immune regulation, oxidative stress, anti-aging well. In recent years, it has been reported that level body closely associated with syndrome, including obesity, hyperglycemia, other pathological factors. Exogenous supplementation improves blood glucose levels, cardiovascular disease risks syndrome. Furthermore, regulates common mechanisms suggesting potential application prospect order to provide theoretical basis for further exploration we focused on syndrome this article summarized latest research progress role improving condition progression For next step, researchers may focus co-pathogenesis investigate whether can be used achieve therapeutic goal "homotherapy heteropathy" treatment

Language: Английский

Citations

0
Effects of combustible cigarettes and electronic nicotine delivery systems on immune cell‐driven inflammation: Evidences from diabetic patients and multiple low dose streptozotocin‐treated diabetic mice DOI
Nikolina Kastratović, Aleksandar Arsenijević,

Carl Randall Harrell

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(9)

Published: Sept. 1, 2024

Considering detrimental impacts of combustible cigarettes (CCs) on the exacerbation diabetes mellitus (DM), a significant number DM patients have substituted CCs with electronic nicotine delivery systems (ENDS). Herewith, we compared and ENDS-dependent modulation immune cell-driven inflammation in who used ENDS (DM

Language: Английский

Citations

0