bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 17, 2023
In
this
investigation,
we
addressed
the
contribution
of
core
circadian
clock
factor,
BMAL1,
in
skeletal
muscle
to
both
acute
transcriptional
responses
exercise
and
remodelling
response
training.
Additionally,
adopted
a
systems
biology
approach
investigate
how
loss
BMAL1
altered
peripheral
tissue
homeostasis
as
well
training
adaptations
iWAT,
liver,
heart,
lung
male
mice.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Feb. 18, 2025
Abstract
Breast
cancer,
characterized
by
unique
epidemiological
patterns
and
significant
heterogeneity,
remains
one
of
the
leading
causes
malignancy-related
deaths
in
women.
The
increasingly
nuanced
molecular
subtypes
breast
cancer
have
enhanced
comprehension
precision
treatment
this
disease.
mechanisms
tumorigenesis
progression
been
central
to
scientific
research,
with
investigations
spanning
various
perspectives
such
as
tumor
stemness,
intra-tumoral
microbiota,
circadian
rhythms.
Technological
advancements,
particularly
those
integrated
artificial
intelligence,
significantly
improved
accuracy
detection
diagnosis.
emergence
novel
therapeutic
concepts
drugs
represents
a
paradigm
shift
towards
personalized
medicine.
Evidence
suggests
that
optimal
diagnosis
models
tailored
individual
patient
risk
expected
are
crucial,
supporting
era
oncology
for
cancer.
Despite
rapid
advancements
increasing
emphasis
on
clinical
comprehensive
update
summary
panoramic
knowledge
related
disease
needed.
In
review,
we
provide
thorough
overview
global
status
including
its
epidemiology,
factors,
pathophysiology,
subtyping.
Additionally,
elaborate
latest
research
into
contributing
progression,
emerging
strategies,
long-term
management.
This
review
offers
valuable
insights
Cancer
Research,
thereby
facilitating
future
progress
both
basic
application.
Molecular Metabolism,
Journal Year:
2024,
Volume and Issue:
86, P. 101980 - 101980
Published: June 29, 2024
In
this
investigation,
we
addressed
the
contribution
of
core
circadian
clock
factor,
BMAL1,
in
skeletal
muscle
to
both
acute
transcriptional
responses
exercise
and
remodeling
response
training.
Additionally,
adopted
a
systems
biology
approach
investigate
how
loss
BMAL1
altered
peripheral
tissue
homeostasis
as
well
training
adaptations
iWAT,
liver,
heart,
lung
male
mice.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(2), P. e41774 - e41774
Published: Jan. 1, 2025
Feeding
disruption
is
closely
linked
to
numerous
diseases,
yet
the
underlying
molecular
mechanisms
remain
an
important
but
unresolved
issue
at
level.
We
hypothesize
that,
network
level,
dietary
disruptions
can
alter
gene
co-expression
patterns,
leading
increase
in
disease-associated
modules,
and
thereby
elevating
likelihood
of
disease
occurrence.
Here,
we
investigate
this
hypothesis
using
transcriptomic
data
from
a
large
cohort
adult
mice
subjected
feeding
disruptions.
Our
computational
analysis
indicates
that
altered
schedules
significantly
disease-related
modules
mouse
livers,
well
before
aging
onset.
Conversely,
calorie
restriction
reduces
these
modules.
This
provides
critical
missing
link
between
disease.
Current Obesity Reports,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: Feb. 13, 2025
Abstract
Purpose
of
the
Review
This
review
summarizes
recent
evidence
for
a
role
clock
in
adipose
tissue
physiology
and
impact
circadian
desynchrony
on
development
obesity.
Recent
Findings
Circadian
disruptions
due
to
shift
work,
late
time
eating
nighttime
light
exposure
are
associated
with
obesity
its
metabolic
cardiovascular
consequences.
Studies
mice
harboring
tissue-specific
gain/loss
function
mutations
genes
revealed
that
acts
multiple
pathways
control
adipogenesis,
lipogenesis/lipolysis
thermogenesis.
Time-restricted
(TRE),
aligning
feeding
active
period
restore
function,
represents
promising
strategy
curb
Summary
While
TRE
has
shown
clear
benefits,
especially
participants
at
higher
cardiometabolic
risk,
current
studies
limited
size
duration.
Larger,
well-controlled
warranted
conclusively
assess
effects
relation
status
gender.
Field
shift-workers,
comparing
permanent
night
versus
rotating
shifts,
also
necessary
identify
optimal
window
TRE.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
2(1)
Published: Feb. 21, 2025
To
most,
if
not
all,
species,
the
food
availability
shows
both
daily
and
seasonal
fluctuations
in
its
timing,
quality,
abundance.
Hence,
coupled
with
appetite
(urge
to
eat),
it
results
species-specific
foraging
(eating
or
feeding)
patterns,
an
ecological
determinant
of
almost
all
aspects
behavior
physiology
animals.
The
feeding
times
control
mutually
inclusive
physiological
events
by
affecting
metabolic
homeostasis
(a
direct
effect)
and/
their
synchronization
effects
on
underlying
circadian
rhythms
(an
indirect
effect).
Experiments
have
shown
that
intake
at
inappropriate
time
day
(i.e.,
a
wrong
relative
internal
clock)
negatively
affects
consequently
behavior,
metabolism
reproduction
as
conditioning
environment
influence
epigenetics,
evidenced
chromatin
activation/
silencing
genome
levels
several
species.
Here,
we
review
briefly
experimental
evidence
largely
from
birds
mammals
provide
insights
into
when
how
affect
clock-controlled
reproductive
fitness
diurnal
npj Metabolic Health and Disease,
Journal Year:
2025,
Volume and Issue:
3(1)
Published: April 9, 2025
Most
aspects
of
physiology
and
behaviour
fluctuate
every
24
h
in
mammals.
These
circadian
rhythms
are
orchestrated
by
an
autonomous
central
clock
located
the
suprachiasmatic
nuclei
that
coordinates
timing
cellular
clocks
tissues
throughout
body.
The
critical
role
this
system
is
emphasized
increasing
evidence
associating
disruption
with
diverse
pathologies.
Accordingly,
mounting
suggests
a
bidirectional
relationship
where
misalignment
may
contribute
to
liver
diseases
while
alter
other
tissues.
Therefore,
pathophysiology
broadly
impact
provide
mechanistic
framework
for
understanding
targeting
metabolic
adjust
setpoints.
