Letter: Clarifying the Synergistic Mechanisms of Mediterranean Diet and Time‐Restricted Feeding in MASLD Management

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

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Scheduled feeding improves sleep in a mouse model of Huntington’s disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Sleep disturbances are common features of neurodegenerative disorders including Huntington's disease (HD). The sleep and circadian disruptions recapitulated in animal models, these models provide the opportunity to evaluate whether interventions can be effective countermeasures for disease. Time restricted feeding (TRF) successfully improve activity rhythms, behavior motor performance mouse HD. Seeking determine if benefits scheduled extend physiological measures sleep, electroencephalography (EEG) was used measure sleep/wake states polysomnographic patterns adult mice (six mo-old) under TRF

Language: Английский

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Circadian rhythm disruption: a potential trigger in Parkinson’s disease pathogenesis

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 30, 2024

Parkinson's disease (PD) is a neurodegenerative characterized by the gradual loss of dopaminergic neurons in substantia nigra pars compacta (SNpc), abnormal accumulation α-synuclein (α-syn), and activation microglia leading to neuroinflammation. Disturbances circadian rhythm play significant role PD, with most non-motor symptoms associated disruptions rhythm. These disturbances can be observed years before motor appear are marked emergence related such as rapid eye movement sleep behavior disorder (RBD), restless leg syndrome (RLS), excessive daytime sleepiness (EDS), depression anxiety, changes blood pressure, gastrointestinal dysfunction, urinary problems. Circadian disruption precedes onset contributes progression PD. In brief, this article outlines triggering PD at cellular molecular levels, well its clinical manifestations. It also explores how research contribute preventing from current future perspectives.

Language: Английский

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Editorial: Circadian rhythm in obesity

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 11, 2024

Keywords: circadian rhythm, clock, obesity, shift workers, disruption, metabolism

Language: Английский

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Theabrownin ameliorated lipid accumulation via modulating circadian rhythms in oleic acid-induced HepG2 cells

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106185 - 106185

Published: April 18, 2024

Theabrownin (TB) is the main characteristic component and bioactive substance of Pu-erh tea. Our previous studies have demonstrated interactions among TB, circadian rhythm, obesity, but underlying mechanism remains unclear. In this study, we focused on by which TB ameliorates lipid accumulation caused oleic acid (OA) modulating rhythm genes in HepG2 cells. The results showed that could reduce triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C) levels, reactive oxygen species (ROS) overproduction droplet formation. Additionally, regulate OA-mediated desynchrony regulating mRNA protein expression genes. Furthermore, as revealed proteomics results, PPAR pathway a potential through metabolism disorders. After Bmal1 knockdown, ameliorative effect OA-induced PPARγ plin1 was decreased, suggested ameliorate cells via Bmal1-dependent pathway.

Language: Английский

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Scheduled feeding improves sleep in a mouse model of Huntington’s disease

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 5, 2024

Sleep disturbances are common features of neurodegenerative disorders including Huntington's disease (HD). and circadian disruptions recapitulated in animal models, providing the opportunity to evaluate effectiveness interventions as countermeasures for disease. For instance, time restricted feeding (TRF) successfully improved activity rhythms, sleep behavior motor performance mouse models HD. Seeking determine if these benefits extend physiological measures sleep, electroencephalography (EEG) was used measure sleep/wake states polysomnographic patterns male female wild-type (WT) bacterial artificial chromosome transgenic (BACHD) adult mice, under TRF

Language: Английский

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Editorial: Circadian rhythm in cellular endocrinology

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 28, 2024

Keywords: circadian rhythm, endocrinology & metabolism, cardiovascular risk, stress responses, chronotherapy

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Modeling mechanisms driving metabolic benefits of time‐restricted eating

Obesity, Journal Year: 2024, Volume and Issue: 32(9), P. 1609 - 1610

Published: July 28, 2024

Eating frequently over waking hours leads to constant levels of metabolic hormones and substrates that may drive systemic insulin resistance dysfunction. In contrast, accumulating evidence suggests consuming food at discrete times (i.e., meals) promotes flexibility health. Time-restricted eating (TRE), early compared with late in the day, is hypothesized promote mobilization fat, but mechanisms involved remain poorly understood. this issue Obesity, Zambrano et al. [(1)] use a cell culture model address timely important topic. initiates shifts metabolism storage dietary fat as triacylglycerol suppress its (lipolysis). fasted state, lower combined short-term increases neural input mobilize triglyceride stores lead release nonesterified fatty acids glycerol provide fuel for peripheral tissues such muscle while sparing glucose brain. Adipocytes integrate these other hormonal signals regulate tissue metabolic, immune, secretory functions maintain [(2, 3)]. These ingestion-related factors are superimposed on cell-autonomous circadian oscillations [(4)]. Additionally, multiple types (including immune) within adipose modulate paracrine microenvironment. Therefore, design cell- tissue-based experiments complex vivo systems exceedingly challenging. To TRE, obtained abdominal subcutaneous from surgeries severe obesity. They several quality control measures: limiting timing sample collection; using small fragments cultured ex vivo; synchronizing rhythms dexamethasone treatment 1 h followed by 1-h washout. they feeding schedule 16 "feeding" standard medium (10% fetal bovine serum [FBS] DMEM) during "light" "fasting" next 8 (modeling dark/sleeping). Fasting was modeled media without any FBS. The accumulation into assessed every 4 day 2. Their main finding increased time since last vitro "meal," well illustrated Figure S1. Several features limit strength authors' conclusions. physiological relevance 0 FBS starvation 10% 25mM not discussed. group's prior studies, extremes concentration were avoided [(3)]. Additional components also impact results should be considered [(5)]. investigators did consider modeling variations key (insulin, cortisol) or acute response catecholamine-stimulated lipolysis, which contribute mobilization. Finally, it whether initial "in vivo" enzymes hormone responsiveness maintained 2 days cultures. simple measurement basal provides only limited insight lipolysis. Assessment steps protein lipase, sensitive lipid droplet perilipin, their phosphorylation future studies. conclusion, report highlights potential role lipolysis mediating effects TRE health, challenges complexity studying nutritional regulation vitro. author declared no conflict interest.

Language: Английский

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Chronic mistimed feeding results in renal fibrosis and disrupted circadian blood pressure rhythms

AJP Renal Physiology, Journal Year: 2024, Volume and Issue: 327(5), P. F683 - F696

Published: Aug. 29, 2024

Circadian disruption is a disturbance in biological timing, which can occur within or between different organizational levels, ranging from molecular rhythms specific cells to the misalignment of behavioral and environmental cycles. Previous work our group showed that less than 1 wk food restriction light (inactive) period sufficient invert diurnal blood pressure mice. However, kidney excretory functions remained aligned with light-dark cycle. Shift workers have an increased risk cardiovascular disease may sexes often irregular mealtimes, making possibility mistimed feeding as potential contributor development disease. Thus, we hypothesized chronic intake would result adverse cardiorenal effects, sex differences severity. Here, show circadian via results renal fibrosis aortic stiffness sex-dependent manner. Our indicate importance meal timing for maintenance function, particularly males. also demonstrate females are better able acclimate circadian-related change.

Language: Английский

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Genetic synchronization of the brain and liver molecular clocks defend against chrono-metabolic disease

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(51)

Published: Dec. 12, 2024

Nearly every cell of the body contains a circadian clock mechanism that is synchronized with light-entrained in suprachiasmatic nucleus (SCN). Desynchrony between SCN and external environment leads to metabolic dysfunction shift workers. Similarly, mice markedly shortened endogenous period due deletion REV-ERBα/β nuclear receptors (SCN DKO) exhibit increased sensitivity diet-induced obesity (DIO) on 24 h light:dark cycle while REV-ERBs deleted hepatocytes (HepDKO) display exacerbated hepatosteatosis response high-fat diet. Here, we show inducing hepatocyte DKO (Hep-SCN DDKO) rescued DIO hepatic triglyceride accumulation, without affecting behavioral period. These findings suggest disturbances environmental desynchrony central are effects peripheral clocks which can be mitigated by matching periods even desynchronous environment. Thus, maintaining synchrony within an organism, rather than exogenous clocks, may viable target for treatment disorders associated disruption.

Language: Английский

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