BIO Integration,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: Jan. 1, 2024
Abstract
Background:
Although
2-methylbutyrylcarnitine
(2MBC)
has
been
associated
with
metabolic
disorders
and
promotes
thrombosis,
its
effect
on
atherosclerosis
remains
elusive.
This
study
was
aimed
at
investigating
the
role
of
2MBC
in
development.
Methods
Results:
Apolipoprotein
E-deficient
(ApoE
−/−
)
mice
were
fed
a
Western
diet
for
18
weeks
to
induce
atherosclerosis,
then
administered
once-daily
gavage
or
vehicle
weeks.
Parameters
systemic
lipid
metabolism
detected.
did
not
upregulate
plasma
total
cholesterol
(TC),
low-density
lipoprotein
(LDL-C),
high-density
(HDL-C)
levels,
triglycerides
(TG)
levels
further
upregulated
Western-diet-induced
treated
2MBC,
thus
suggesting
that
this
compound
may
contribute
hypertriglyceridemia.
In
addition,
had
no
development,
as
evidenced
by
alterations
plaque
area,
exacerbation
local
inflammation,
effects
stability.
RAW264.7
macrophages
used
investigate
oxidized
lipoprotein-induced
foam
cell
formation
vitro.
Treatment
affect
uptake
cells.
The
addition
relative
mRNA
inflammation-associated
genes
when
lipopolysaccharide.
destructive
vascular
endothelium,
we
stimulated
human
umbilical
vein
endothelial
cells
(HUVECs)
(ox-LDL).
Ox-LDL
alter
expression
monocyte
chemotactic
protein-1
adhesion
molecule-1.
Furthermore,
combined
ox-LDL
stimulation
SR-A1
ABCA1
HUVECs.
Conclusions:
Our
provides
first
evidence
does
promote
increase
intravascular
exacerbate
degree
stability
ApoE
mice.
International Journal of Oral Science,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Oct. 15, 2024
Periodontitis
is
a
chronic
inflammatory
disease
initiated
by
biofilm
microorganisms
and
mediated
host
immune
imbalance.
Uncontrolled
periodontal
infections
are
the
leading
cause
of
tooth
loss
in
adults.
Thrombotic
diseases
can
lead
to
partial
or
complete
obstruction
blood
flow
circulatory
system,
manifesting
as
organ
tissue
ischemia
necrosis
patients
with
arterial
thrombosis,
local
edema,
pain
instability
venous
which
may
mortality
fatality
severe
case.
Recent
studies
found
that
periodontitis
might
enhance
thrombosis
through
bacterial
transmission
systemic
inflammation
affecting
platelet-immune
cell
interactions,
well
coagulation,
therapy
could
have
prophylactic
effect
on
thrombotic
diseases.
In
this
review,
we
summarized
clinical
findings
association
between
discussed
several
novel
prothrombotic
periodontitis-related
agents,
presented
perspective
emphasize
necessity
oral
health
management
for
people
at
high
risk
thrombosis.
Inter Collegas,
Journal Year:
2024,
Volume and Issue:
11(1), P. 15 - 26
Published: March 31, 2024
Introduction.
The
impact
of
circulating
amino
acid
levels
and
their
combinations
on
the
pathogenesis
ischemic
heart
disease
atrial
fibrillation
is
a
current
issue,
otherwise,
platelets
spectrum
still
under
discussion,
despite
known
pathogenetic
role
in
these
disorders.
Aim.
To
compare
changes
plasma
patients
with
coronary
artery
as
well
to
find
connections.
Materials
&
Methods.
300
were
divided
into
3
groups:
I
group
–
149
without
arrhythmias,
II
124
paroxysm,
control
27
arrhythmias.
Plasma
platelet
detected
by
means
ion
exchange
liquid
column
chromatography.
Results
Conclusions.
In
spectrum,
significant
rise
leucine
(12.63%),
isoleucine
(10.73%),
Fishers’
ratio
(6.37%);
decrease
threonine
(23.05%),
valine
(30.83%)
levels,
glycine
(32.21%),
serine
(5.06%),
glycine+serine
sum
(20.51%)
2
was
found
compared
1,
p<0.05.
acids
increase
glutamate,
branched-chain
acids,
checked
comparison
Only
10
moderate
strength
correlations
revealed
between
investigated
patient’s
groups.
These
not
significantly
congruent
fibrillation.
should
be
analyzed
separately
for
further
studies
evaluation
new
prognostic
markers
clues
development.
Keywords:
myocardial
ischemia,
rhythm
violations,
proteins,
metabolomics.
BIO Integration,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: Jan. 1, 2024
Abstract
Background:
Although
2-methylbutyrylcarnitine
(2MBC)
has
been
associated
with
metabolic
disorders
and
promotes
thrombosis,
its
effect
on
atherosclerosis
remains
elusive.
This
study
was
aimed
at
investigating
the
role
of
2MBC
in
development.
Methods
Results:
Apolipoprotein
E-deficient
(ApoE
−/−
)
mice
were
fed
a
Western
diet
for
18
weeks
to
induce
atherosclerosis,
then
administered
once-daily
gavage
or
vehicle
weeks.
Parameters
systemic
lipid
metabolism
detected.
did
not
upregulate
plasma
total
cholesterol
(TC),
low-density
lipoprotein
(LDL-C),
high-density
(HDL-C)
levels,
triglycerides
(TG)
levels
further
upregulated
Western-diet-induced
treated
2MBC,
thus
suggesting
that
this
compound
may
contribute
hypertriglyceridemia.
In
addition,
had
no
development,
as
evidenced
by
alterations
plaque
area,
exacerbation
local
inflammation,
effects
stability.
RAW264.7
macrophages
used
investigate
oxidized
lipoprotein-induced
foam
cell
formation
vitro.
Treatment
affect
uptake
cells.
The
addition
relative
mRNA
inflammation-associated
genes
when
lipopolysaccharide.
destructive
vascular
endothelium,
we
stimulated
human
umbilical
vein
endothelial
cells
(HUVECs)
(ox-LDL).
Ox-LDL
alter
expression
monocyte
chemotactic
protein-1
adhesion
molecule-1.
Furthermore,
combined
ox-LDL
stimulation
SR-A1
ABCA1
HUVECs.
Conclusions:
Our
provides
first
evidence
does
promote
increase
intravascular
exacerbate
degree
stability
ApoE
mice.
