Current Oncology,
Journal Year:
2024,
Volume and Issue:
31(12), P. 7852 - 7862
Published: Dec. 6, 2024
Frailty
and
myosteatosis
are
each
prognostic
of
all-cause
mortality
(ACM)
in
patients
with
cancer.
However,
it
is
unclear
whether
adds
value
to
frailty
for
predicting
ACM.
We
assessed
improves
the
predictive
ability
ACM
older
adults
undergoing
chemotherapy.
This
was
a
retrospective
study
(≥65
years)
initiating
chemotherapy
between
June
2015
2022.
using
24-item
index
(FI).
Myosteatosis
evaluated
via
computed
tomography
scans
at
third
lumbar
vertebra
(L3)..
Multivariable
Cox
regression
Uno’s
c-statistic
determined
performance
FI
myosteatosis.
In
total,
115
participants
(mean
age:
77.1
were
included.
alone
(adjusted
hazards
ratio
(aHR)
=
1.68,
95%
confidence
intervals
(CIs)
1.03–2.72,
p
0.037)
(aHR
2.14,
95%CI
1.07–4.30,
0.032)
exhibited
similar
(c-statistic
0.66)
multivariable
analyses
adjusted
age,
sex,
body
mass
index,
treatment
intent.
highest
observed
after
inclusion
both
model
0.70).
Prospective
studies
assess
effect
exercise
on
warranted.
Journal of Internal Medicine,
Journal Year:
2024,
Volume and Issue:
296(5), P. 382 - 398
Published: Oct. 1, 2024
Frailty
and
delirium
are
two
common
geriatric
syndromes
sharing
several
clinical
characteristics,
risk
factors,
negative
outcomes.
Understanding
their
interdependency
is
crucial
to
identify
shared
mechanisms
implement
initiatives
reduce
the
associated
burden.
This
literature
review
summarizes
scientific
evidence
on
complex
interplay
between
frailty
delirium;
clinical,
epidemiological,
pathophysiological
commonalities;
current
knowledge
gaps.
We
conducted
a
PubMed
systematic
search
in
June
2023,
which
yielded
118
eligible
articles
out
of
991.
The
synthesis
results-carried
by
content
experts-highlights
overlapping
phenotypes,
outcomes
explores
influence
one
syndrome
onset
other.
Common
identified
include
inflammation,
neurodegeneration,
metabolic
insufficiency,
vascular
suggests
that
factor
for
delirium,
with
some
support
accelerated
frailty.
proposed
unifying
framework
supports
integration
measurement
both
constructs
research
practice,
identifying
geroscience
approach
as
potential
avenue
develop
strategies
conditions.
In
conclusion,
we
suggest
might
be
alternative-sometimes
coexisting-manifestations
biological
aging.
Clinically,
concepts
addressed
this
can
help
older
adults
either
or
from
different
perspective.
From
standpoint,
longitudinal
studies
needed
explore
hypothesis
specific
pathways
within
biology
aging
may
underlie
manifestations
delirium.
Such
will
pave
way
future
understanding
other
well.
Life,
Journal Year:
2025,
Volume and Issue:
15(1), P. 81 - 81
Published: Jan. 10, 2025
Introduction:
Metabolic
syndrome
(MetS)
and
hypertriglyceridemic
waist
(HTW)
are
two
multifactorial
pathological
conditions
that
have
been
increasing
in
prevalence
worldwide.
The
objective
of
this
study
was
to
evaluate
how
various
sociodemographic
variables
healthy
habits
associated
with
the
presence
or
absence
MetS
HTW.
Methodology:
This
employed
a
mixed-methods
approach,
consisting
retrospective
longitudinal
cross-sectional
descriptive
study,
analyzing
44,939
healthcare
workers
MS
HTW
across
four
professional
categories
relationship
between
age,
sex,
smoking,
physical
activity,
adherence
Mediterranean
diet
using
three
diagnostic
criteria.
Descriptive
analysis
included
categorical
quantitative
variables,
which
were
assessed
through
frequencies,
Student's
t-test,
chi-square,
binary
logistic
regression
models.
Logistic
Cohen's
kappa
used
associations
concordances.
Age,
lack
activity
showed
strongest
(OR:
2.65-2.84).
results
highlight
importance
other
factors
metabolic
prevention.
Results:
most
strongly
evaluated
odds
ratios
revealed
significant
values:
age
(9.07-13.71
for
13.42
HTW),
sex
(2.82-3.31
3.72
(2.65-2.84
2.40
HTW).
Conclusions:
risk
developing
among
personnel
is
influenced
by
lifestyle
habits,
highest
ORs
observed
nursing
assistants
orderlies.
Future
research
delves
deeper
into
causal
severity
will
improve
understanding
facilitate
development
preventive
activities
reduce
their
incidence.
Diseases,
Journal Year:
2025,
Volume and Issue:
13(2), P. 33 - 33
Published: Jan. 27, 2025
Introduction:
Insulin
resistance
(IR)
is
a
highly
prevalent
pathophysiological
entity
implicated
in
the
development
of
wide
variety
metabolic,
cardiovascular,
and
endocrine
disorders.
The
aim
this
study
to
assess
association
between
sociodemographic
variables
healthy
habits
with
IR
risk
scales.
Methodology:
This
dual
study,
incorporating
both
longitudinal-retrospective
cross-sectional
designs,
analyzed
healthcare
workers
across
four
professional
categories
(physicians,
nurses,
technicians,
auxiliary
personnel).
It
examined
age,
sex,
category,
smoking
status,
physical
activity,
adherence
Mediterranean
diet
elevated
scores
on
insulin
Results:
All
were
associated
presence
values
scales,
activity
showing
strongest
(reflected
odds
ratio
values).
Conclusions:
profile
an
individual
higher
presenting
scales
would
be
elderly
male
health
worker
who
smoker
physically
inactive,
low
diet.
Current Opinion in Psychiatry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
Purpose
of
review
Depression
and
physical
illnesses
have
long
been
recognized
as
risk
factors
for
suicidal
behaviour
in
late
life.
Qualitative
studies
previously
identified
frailty
being
an
issue
life
behaviour,
but
quantitative
lacking.
Establishing
the
role
plays
has
implications
suicide
prevention.
Recent
findings
are
closely
linked
life,
with
genetic
social
suggesting
bidirectional
causality.
Frailty
is
associated
increased
ideation
attempts
that
likely
enhanced
by
chronicity,
depression,
factors,
such
living
eating
alone.
In
contrast,
lower
levels
frailty.
Summary
Suicide
rates
peak
depression
a
consistently
factor
along
numerous
diverse
include
health
issues.
investigating
relationship
between
neglected
until
recently.
Interventions
reduce
or
prevent
training
nutritional
management
interventions,
might
preventing
behaviour.
Further
research
required
to
elucidate
different
associations
reported
ideation/attempts
suicide.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Frailty
is
an
age-related
geriatric
syndrome,
for
which
the
mechanisms
remain
largely
unknown.
We
performed
a
longitudinal
study
of
aging
female
(n
=
40)
and
male
47)
C57BL/6NIA
mice,
measured
frailty
index
derived
metabolomics
data
from
plasma
samples.
identify
differentially
abundant
metabolites
related
to
aging,
determine
via
machine
learning
approach,
generate
union
set
features,
both
in
whole
cohort
sex-stratified
subgroups.
Using
we
perform
association
build
metabolomics-based
clock.
find
that
are
enriched
amino
acid
metabolism
cofactors
vitamins,
include
ergothioneine,
tryptophan,
alpha-ketoglutarate,
present
sex
dimorphism.
B
vitamin
flavin
adenine
dinucleotide
pyridoxate
as
female-specific
biomarkers,
lipid
sphingomyelins,
glycerophosphoethanolamine
glycerophosphocholine
male-specific
biomarkers.
These
associations
confirmed
validation
cohort,
with
ergothioneine
perfluorooctanesulfonate
identified
robust
In
summary,
our
results
sex-specific
metabolite
biomarkers
shed
light
on
potential
involved
frailty.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(5), P. 2504 - 2504
Published: Feb. 26, 2025
Japan
is
facing
challenges
associated
with
its
super-aging
society,
including
increased
social
security
burdens
and
a
rise
in
the
elderly
workforce
due
to
declining
younger
labor
force.
Extending
healthy
life
expectancy
one
countermeasure,
necessitating
lifestyle
improvements
such
as
frailty
prevention
ensuring
adequate
sleep
duration.
This
study
investigated
relationship
between
heart
rate
variability
(HRV)
duration
among
older
adults
(aged
≥
65)
using
electrocardiogram
(ECG)
three-axis
accelerometer
data
from
Allostatic
State
Mapping
by
Ambulatory
ECG
Repository
(ALLSTAR)
database,
recorded
January
2019
March
2021.
Inclusion
criteria
required
sinus
rhythm
recording
durations
≥80%.
Continuous
24
h
were
analyzed
for
55,154
participants
(mean
age
76
±
6).
The
results
consistently
showed
significant
differences
HRV
metrics,
MRRI,
SDRR,
ULF,
LF,
HF,
LF/HF,
across
groups
(G1–G4).
Short-sleep
(G4)
exhibited
decreased
MRRI
SDRR
suggesting
active
lifestyles
but
reduced
HRV.
Conversely,
long-sleep
(G1)
LF/HF
age-related
declines
ULF.
These
findings
indicate
that
both
insufficient
excessive
may
contribute
reduction
adults.
provides
critical
insights
improving
through
tailored
interventions
exercise
management.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2689 - 2689
Published: Aug. 13, 2024
Alterations
in
the
body’s
nutritional
status
or
composition
may
be
observed
as
kidney
disease
advances,
which
could
influence
kidney’s
functional
capacity
and,
consequently,
increase
risk
of
mortality.
The
aim
study
is
to
determine
on
mortality
assessed
by
different
tests
patients
with
advanced
chronic
(ACKD).
A
prospective
observational
was
designed,
included
225
followed
for
8
years
a
CKD
clinic.
using
range
tests,
Short
Physical
Performance
Battery,
6
minutes
walking
gait
test,
timed
up
and
go,
four
versions
sit-to-stand
test.
Additionally,
body
conditions
were
considered,
taking
into
consideration
various
biochemical
indicators
such
albumin,
prealbumin,
c-reactive
protein
(CRP),
lymphocytes,
transferrin,
muscle
strength,
comorbidity,
frailty.
relationship
between
functionality
all-cause
investigated
Cox
proportional
hazard
model.
total
fifty
died
during
duration
study.
Patients
who
performed
worse
function
strength
showed
status,
exhibited
reduced
life
expectancy.
Inflammation
(CRP)
associated
an
increased
(model
1:
ratio
(HR)
=
1.246;
95%
confidence
interval
(95%
CI
1.014–1.531;
model
2:
HR
1.333;
1.104–1.610).
Good
determined
SPPB
test
decreased
0.764;
0.683–0.855;
2
0.778;
0.695–0.872).
Cut-off
points
maximum
sensitivity
specificity
obtained
tests.
demonstrated
that
influences
ACKD,
being
higher
those
impaired
regardless
used,
although
allows
larger
number
assessed.
Therefore,
it
essential
incorporate
assessment
comprehensive
care
CKD.
