Disrupted sleep, disrupted metabolism: A potential link between circadian rhythms and tumorigenesis DOI Creative Commons

Sarah Asif,

Martha U. Gillette

Brain Behavior and Immunity Integrative, Journal Year: 2024, Volume and Issue: 7, P. 100070 - 100070

Published: July 1, 2024

Language: Английский

Circadian Rhythm, Microglia-Mediated Neuroinflammation, and Alzheimer’s Disease DOI
Fan Geng, Na Zhao, Qingguo Ren

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 170, P. 106044 - 106044

Published: Feb. 4, 2025

Language: Английский

Citations

4

Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers DOI Creative Commons
Siqi Li, Hang Yuan, Liang Li

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201

Published: Feb. 10, 2025

Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.

Language: Английский

Citations

4

The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies DOI Creative Commons
Jie Wang, Fanglin Shao, Qingxin Yu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

Citations

3

Characterization of ferroptosis-triggered pyroptotic signaling in heart failure DOI Creative Commons

Xukun Bi,

Xiaotian Wu,

Jiaqi Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 25, 2024

Language: Английский

Citations

16

Regulation of CD8+ T cells by lipid metabolism in cancer progression DOI Creative Commons
Yong Tang, Ziqing Chen, Qianying Zuo

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(11), P. 1215 - 1230

Published: Oct. 14, 2024

Dysregulation of lipid metabolism is a key characteristic the tumor microenvironment, where cells utilize lipids for proliferation, survival, metastasis, and evasion immune surveillance. Lipid has become critical regulator CD8+ T-cell-mediated antitumor immunity, with excess in microenvironment impeding T-cell activities. Considering limited efficacy immunotherapy many solid tumors, targeting to enhance effector functions could significantly improve outcomes. In this review, we examine recent findings on how metabolic processes, including uptake, synthesis, oxidation, regulate T within tumors. We also assessed impact different particular focus affects mitochondrial function tumor-infiltrating cells. Furthermore, as cancer systemic disease, examined factors linking function. Finally, summarize current therapeutic approaches that target increase immunity immunotherapy. Understanding molecular functional interplay between offers promising opportunities treatment.

Language: Английский

Citations

10

Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment DOI Creative Commons

Qibo Huang,

Bai Hu,

Zhang Ping

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 17, 2025

The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected tumorigenesis. In particular, peripheral central nervous systems, synapse, neurotransmitters, neurotrophins affect progression metastasis through various regulatory approaches immune microenvironment. this review, we summarized tumorigenesis metastasis, which controlled by systems. We also explored roles neurotransmitters progression. Moreover, examined interplay system have identified drugs target treatment. review present work supporting agent targeting could potential to improve therapy.

Language: Английский

Citations

2

Turning cold into hot: emerging strategies to fire up the tumor microenvironment DOI
Kejing Ma, Lin Wang, Wenhui Li

et al.

Trends in cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

9

Targeting ACSLs to modulate ferroptosis and cancer immunity DOI
Junhong Lin,

Yongfeng Lai,

Fujia Lu

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

7

Rhythm is essential: Unraveling the relation between the circadian clock and cancer DOI
Olajumoke Ogunlusi, A. Ghosh, Mrinmoy Sarkar

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104632 - 104632

Published: Jan. 1, 2025

Language: Английский

Citations

1

Sleep deprivation-induced sympathetic activation promotes pro-tumoral macrophage phenotype via the ADRB2/KLF4 pathway to facilitate NSCLC metastasis DOI Creative Commons

Shuxian Yin,

Jiali Wang, Yunlong Jia

et al.

iScience, Journal Year: 2025, Volume and Issue: unknown, P. 112321 - 112321

Published: March 1, 2025

Language: Английский

Citations

1