Brain Behavior and Immunity Integrative, Journal Year: 2024, Volume and Issue: 7, P. 100070 - 100070
Published: July 1, 2024
Language: Английский
Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 170, P. 106044 - 106044
Published: Feb. 4, 2025
Language: Английский
Citations
4
Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201
Published: Feb. 10, 2025
Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.
Language: Английский
Citations
4
Research, Journal Year: 2025, Volume and Issue: 8
Published: Jan. 1, 2025
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.
Language: Английский
Citations
3
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 25, 2024
Language: Английский
Citations
16
Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(11), P. 1215 - 1230
Published: Oct. 14, 2024
Dysregulation of lipid metabolism is a key characteristic the tumor microenvironment, where cells utilize lipids for proliferation, survival, metastasis, and evasion immune surveillance. Lipid has become critical regulator CD8+ T-cell-mediated antitumor immunity, with excess in microenvironment impeding T-cell activities. Considering limited efficacy immunotherapy many solid tumors, targeting to enhance effector functions could significantly improve outcomes. In this review, we examine recent findings on how metabolic processes, including uptake, synthesis, oxidation, regulate T within tumors. We also assessed impact different particular focus affects mitochondrial function tumor-infiltrating cells. Furthermore, as cancer systemic disease, examined factors linking function. Finally, summarize current therapeutic approaches that target increase immunity immunotherapy. Understanding molecular functional interplay between offers promising opportunities treatment.
Language: Английский
Citations
10
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 17, 2025
The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected tumorigenesis. In particular, peripheral central nervous systems, synapse, neurotransmitters, neurotrophins affect progression metastasis through various regulatory approaches immune microenvironment. this review, we summarized tumorigenesis metastasis, which controlled by systems. We also explored roles neurotransmitters progression. Moreover, examined interplay system have identified drugs target treatment. review present work supporting agent targeting could potential to improve therapy.
Language: Английский
Citations
2
Trends in cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
9
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
7
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104632 - 104632
Published: Jan. 1, 2025
Language: Английский
Citations
1
iScience, Journal Year: 2025, Volume and Issue: unknown, P. 112321 - 112321
Published: March 1, 2025
Language: Английский
Citations
1