Role of Abscisic Acid in the Whole-Body Regulation of Glucose Uptake and Metabolism DOI Open Access
Sonia Spinelli,

Zelle Humma,

Mirko Magnone

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 13 - 13

Published: Dec. 24, 2024

Abscisic acid (ABA) is a hormone with long evolutionary history, dating back to the earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely descendants, existed before separation plant and animal kingdoms, conserved role as signals regulating cell responses environmental challenges. In mammals, along anti-inflammatory neuroprotective function ABA, nanomolar ABA regulates metabolic response glucose availability by stimulating uptake in skeletal muscle adipose tissue via an insulin-independent mechanism increasing energy production also dissipation brown white adipocytes. Chronic intake micrograms per Kg body weight improves blood glucose, lipids, morphometric parameters (waist circumference mass index) borderline subjects for prediabetes syndrome. This review summarizes most recent vitro vivo data obtained involvement receptors LANCL1 LANCL2 hormone’s action, importance mammals’ endowment two distinct hormones governing availability. Finally, unresolved issues future directions clinical use diabetes discussed.

Language: Английский

Role of Abscisic Acid in the Whole-Body Regulation of Glucose Uptake and Metabolism DOI Open Access
Sonia Spinelli,

Zelle Humma,

Mirko Magnone

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 13 - 13

Published: Dec. 24, 2024

Abscisic acid (ABA) is a hormone with long evolutionary history, dating back to the earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely descendants, existed before separation plant and animal kingdoms, conserved role as signals regulating cell responses environmental challenges. In mammals, along anti-inflammatory neuroprotective function ABA, nanomolar ABA regulates metabolic response glucose availability by stimulating uptake in skeletal muscle adipose tissue via an insulin-independent mechanism increasing energy production also dissipation brown white adipocytes. Chronic intake micrograms per Kg body weight improves blood glucose, lipids, morphometric parameters (waist circumference mass index) borderline subjects for prediabetes syndrome. This review summarizes most recent vitro vivo data obtained involvement receptors LANCL1 LANCL2 hormone’s action, importance mammals’ endowment two distinct hormones governing availability. Finally, unresolved issues future directions clinical use diabetes discussed.

Language: Английский

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