Lactylation and Central Nervous System Diseases DOI Creative Commons
Ye Chen, Dongqiong Xiao, Xihong Li

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 294 - 294

Published: March 11, 2025

As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases mediates lactylation, epigenetic modification that occurs under both physiological pathological conditions. Lactylation is a crucial mechanism by which exerts its functions, participating vital biological activities such glycolysis-related cellular macrophage polarization, nervous system regulation. links metabolic regulation to central (CNS) diseases, traumatic brain injury, Alzheimer’s disease, acute ischemic stroke, schizophrenia, revealing diverse functions lactylation CNS. In future, further exploration lactylation-associated enzymes proteins needed develop specific inhibitors or activators, could provide new tools strategies for treatment CNS diseases.

Language: Английский

Lactylation and regulated cell death DOI
Wenlong Zhang, Guangyao Shan, Guoshu Bi

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(4), P. 119927 - 119927

Published: Feb. 28, 2025

Language: Английский

Citations

0
Lactylation of PLBD1 Facilitates Brain Injury Induced by Ischemic Stroke DOI Creative Commons

Faming Zhou,

Guang‐Hui Chen,

Xiaoli Li

et al.

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 25, 2025

Background: Ischemic stroke is a prevalent global condition and its associated brain damage poses significant threat to patient survival outcomes. The underlying mechanisms of ischemic stroke-induced injury remain elusive, necessitating further investigation. Methods: models were established using middle cerebral artery occlusion (MCAO) in animals oxygen-glucose deprivation reperfusion (OGD-R) cells. Phospholipase B domain-containing protein 1 (PLBD1) expression these was assessed via western blotting analysis, reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), cell immunofluorescence. A comprehensive evaluation, incorporating cellular lactate dehydrogenase (LDH) release assays, glycolysis metabolism kits, RT-qPCR, blotting, triphenyl tetrazolium chloride (TTC) staining, neurological scoring, tissue water content measurement, creatine kinase-MB (CK-MB) conducted determine the impact PLBD1 on injury. Potential lactylation sites predicted DeepKla database, with co-immunoprecipitation (Co-IP) confirming site. Results: significantly upregulated MCAO animal OGD-R-treated knockdown markedly mitigated OGD-R-induced injury, suppressed vitro, reversed MCAO-induced vivo. Furthermore, at K155 site enhanced response elevated levels following OGD-R treatment. These results indicated that upregulation plays pivotal role exacerbating damage. Conclusion: Targeting lactate/PLBD1 axis presents promising therapeutic strategy for management.

Language: Английский

Citations

0
Single-cell RNA sequencing-guided engineering of mitochondrial therapies for intervertebral disc degeneration by regulating mtDNA/SPARC-STING signaling DOI
Guoyu Yang,

Chenpeng Dong,

Zhaoxi Wu

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 564 - 582

Published: March 1, 2025

Language: Английский

Citations

0
Energy Metabolism Supports Molecular and Functional Heterogeneity of Reactive Astrocytes in Central Nervous System Disorders DOI Open Access

Jie Song,

Jianning Kang,

Ying Zhang

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

ABSTRACT Astrocytes undergo a reactive transformation in central nervous system (CNS) disorders, manifesting significant heterogeneity morphology, molecules, function, and spatial distribution. Just like all cells, astrocytes necessitate energy for their basic functions. Energy production proves critical the survival development of astrocytes, as well fate determination functional diversity. The activation process involves metabolic shift energy, yet our understanding how this change impacts remains limited. In comprehensive review, we begin by outlining advancements research on CNS establishing crucial association between metabolism molecular aspects. Following this, delve into thorough analysis transitions within context diseases. Starting from essential pathways metabolism, present novel perspective, shedding light considering metabolism. conclusion, propose that modulation coupled with promotion functionality toward disease recovery, represents cutting‐edge promising strategy treatment

Language: Английский

Citations

0
Lactylation and Central Nervous System Diseases DOI Creative Commons
Ye Chen, Dongqiong Xiao, Xihong Li

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 294 - 294

Published: March 11, 2025

As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases mediates lactylation, epigenetic modification that occurs under both physiological pathological conditions. Lactylation is a crucial mechanism by which exerts its functions, participating vital biological activities such glycolysis-related cellular macrophage polarization, nervous system regulation. links metabolic regulation to central (CNS) diseases, traumatic brain injury, Alzheimer’s disease, acute ischemic stroke, schizophrenia, revealing diverse functions lactylation CNS. In future, further exploration lactylation-associated enzymes proteins needed develop specific inhibitors or activators, could provide new tools strategies for treatment CNS diseases.

Language: Английский

Citations

0