Association of TyG Index and TG/HDL-C Ratio with Trajectories of Depressive Symptoms: Evidence from China Health and Retirement Longitudinal Study DOI Open Access
Tingting Guo, Qing Zou, Qi Wang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4300 - 4300

Published: Dec. 12, 2024

Objectives: To explore whether the triglyceride–glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio are associated with trajectories of depressive symptoms. Methods: In this longitudinal study, 4215 participants aged 45 years older were recruited from China Health Retirement Longitudinal Study 2011 2018. The symptoms, measured by 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), identified using group-based trajectory modeling. Multinomial logistic models restricted cubic spline analysis used investigate relationships between TyG TG/HDL-C Stratified analyses conducted based on sex, age, place residence, body mass (BMI). Results: Five distinct symptoms characterized stable low, moderate, decreasing, increasing, high during a follow-up 7 years. associations not entirely consistent. After adjusting covariates, higher at baseline was lower odds being decreasing (ORad = 0.61, 95% CI: 0.40–0.92) compared low trajectory, revealed negative linear relationship likelihood However, no longer statistically significant when all confounders controlled 0.72, 0.50−1.04). Additionally, association observed among 45–64-year-old individuals, female participants, those living in rural areas, normal BMI. Limitations: This study middle-aged elderly population China, extrapolation other regions populations requires further confirmation. Conclusions: Compared ratio, may be better predictor adults. Considering that pathology depression progresses long term, our findings have utility identifying available reliable markers development depression.

Language: Английский

Dysregulation of energy metabolism in Alzheimer's disease DOI Creative Commons
Yue Yuan, Gang Zhao, Yang Zhao

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: 272(1)

Published: Dec. 2, 2024

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Its etiology and associated mechanisms are still unclear, which largely hinders development AD treatment strategies. Many studies have shown that dysregulation energy metabolism in brain closely related to development. Dysregulation with reduced glucose uptake utilization, altered insulin signaling pathways, mitochondrial dysfunction. In this study, we summarized relevant pathways regarding AD. addition, highlight possible role dysfunction as a central process. A deeper understanding relationship between may provide new insights for learning memory impairment patients improving prevention treatment.

Language: Английский

Citations

1
Nourishing the mind: Fasting for brain health DOI
Sebastian J. Hofer, Frank Madeo

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(8), P. 1635 - 1637

Published: Aug. 1, 2024

Language: Английский

Citations

0
Association of TyG Index and TG/HDL-C Ratio with Trajectories of Depressive Symptoms: Evidence from China Health and Retirement Longitudinal Study DOI Open Access
Tingting Guo, Qing Zou, Qi Wang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4300 - 4300

Published: Dec. 12, 2024

Objectives: To explore whether the triglyceride–glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio are associated with trajectories of depressive symptoms. Methods: In this longitudinal study, 4215 participants aged 45 years older were recruited from China Health Retirement Longitudinal Study 2011 2018. The symptoms, measured by 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), identified using group-based trajectory modeling. Multinomial logistic models restricted cubic spline analysis used investigate relationships between TyG TG/HDL-C Stratified analyses conducted based on sex, age, place residence, body mass (BMI). Results: Five distinct symptoms characterized stable low, moderate, decreasing, increasing, high during a follow-up 7 years. associations not entirely consistent. After adjusting covariates, higher at baseline was lower odds being decreasing (ORad = 0.61, 95% CI: 0.40–0.92) compared low trajectory, revealed negative linear relationship likelihood However, no longer statistically significant when all confounders controlled 0.72, 0.50−1.04). Additionally, association observed among 45–64-year-old individuals, female participants, those living in rural areas, normal BMI. Limitations: This study middle-aged elderly population China, extrapolation other regions populations requires further confirmation. Conclusions: Compared ratio, may be better predictor adults. Considering that pathology depression progresses long term, our findings have utility identifying available reliable markers development depression.

Language: Английский

Citations

0