Disruption of Hepatic Sinusoidal Homeostasis Leads to Hepatopulmonary Syndrome DOI Creative Commons
Jiaxin Chen,

Yangkun Guo,

Xiaoxun Zhang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(9)

Published: May 1, 2025

ABSTRACT Hepatopulmonary syndrome (HPS) is a pulmonary vascular complication of liver disease and/or portal hypertension. HPS manifests as impaired gas exchange and hypoxemia due to intrapulmonary dilatations shunts. In response primary disease, the abnormal adaptation respiratory epithelial cells, endothelial cells immune leads microenvironment disequilibrium HPS. this review, we explore pathophysiologic mechanisms HPS, including dilation, angiogenesis alveolar dysfunction. The contributor transplantation only treatment that generally reverses We then discuss how disruption hepatic sinusoidal homeostasis may impact progression mainly focusing on hepatocytes, cholangiocytes, LSECs macrophages. As occurs more commonly in advanced cirrhosis, also normalisation dysfunction hypertension crucial for resolution conclusion, liver‐targeted therapies be effective treating

Language: Английский

Advances in intrahepatic and extrahepatic vascular dysregulations in cirrhotic portal hypertension DOI Creative Commons
Yanqiu Li, Bingbing Zhu, Ke Shi

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Cirrhotic portal hypertension, the most prevalent and clinically significant complication of liver cirrhosis, manifests as elevated venous pressure is associated with severe complications. Although much research on mechanisms hypertension has focused fibrosis, less attention been given to role intrahepatic extrahepatic vascular dysfunction, particularly respect vasculature. While hepatic fibrosis in cirrhotic undeniable, underlying involving vasculature are highly complex. Sinusoidal capillarization endothelial dysfunction contribute increased resistance. Hemodynamic changes circulation, including splanchnic vasodilation hyperdynamic play a development hypertension. Additionally, therapeutic strategies targeting these diverse, improvement sinusoidal microcirculation, therapies stellate cells activation, pharmacological modulation systemic tone. Therefore, this review, we will discuss vascular-related treatment progress cirrhosis provide new theoretical basis practical guidance for clinical treatment.

Language: Английский

Citations

0
Protocol for monitoring intrapulmonary vasodilation in mice using contrast-enhanced echocardiography DOI Creative Commons
Nityanand Bolshette,

Hanna Bueno-Levy,

Gad Asher

et al.

STAR Protocols, Journal Year: 2025, Volume and Issue: 6(1), P. 103647 - 103647

Published: Feb. 20, 2025

Language: Английский

Citations

0
Control of circadian muscle glucose metabolism through the BMAL1–HIF axis in obesity DOI Creative Commons
Claire Chaikin, Abhishek Vijay Thakkar, Adam W. T. Steffeck

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(13)

Published: March 24, 2025

Disruptions of circadian rhythms are widespread in modern society and lead to accelerated worsened symptoms metabolic syndrome. In healthy mice, the clock factor BMAL1 is required for skeletal muscle function metabolism. However, importance development diseases, such as diet-induced obesity (DIO), remains unclear. Here, we demonstrate that muscle–specific BMAL1-deficient mice exhibit glucose tolerance upon high-fat diet feeding, despite no evidence increased weight gain. Metabolite profiling from Bmal1 -deficient muscles revealed impaired utilization specifically at early steps glycolysis dictate switch between anabolic catabolic fate. We provide this due abnormal control nutrient stress–responsive hypoxia-inducible (HIF) pathway. Genetic HIF1α stabilization restores expression 217/736 dysregulated genes during DIO, including glycolytic enzymes. Together, these data indicate an important regulator HIF-driven flexibility, which influences high-fat-diet-induced intolerance.

Language: Английский

Citations

0
Integrating cancer medicine into metabolic rhythms DOI
Keyu Su,

Deshun Zeng,

Weiru Zhang

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Heart-attack outcomes are worse in the morning when activity of protein duo dips DOI
Ariana Kupai, Clara Bien Peek

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0
Circadian clock controlled glycolipid metabolism and its relevance to disease management DOI

Luomin Lin,

Yuwei Huang, Aijing Li

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116967 - 116967

Published: April 1, 2025

Language: Английский

Citations

0
Disruption of Hepatic Sinusoidal Homeostasis Leads to Hepatopulmonary Syndrome DOI Creative Commons
Jiaxin Chen,

Yangkun Guo,

Xiaoxun Zhang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(9)

Published: May 1, 2025

ABSTRACT Hepatopulmonary syndrome (HPS) is a pulmonary vascular complication of liver disease and/or portal hypertension. HPS manifests as impaired gas exchange and hypoxemia due to intrapulmonary dilatations shunts. In response primary disease, the abnormal adaptation respiratory epithelial cells, endothelial cells immune leads microenvironment disequilibrium HPS. this review, we explore pathophysiologic mechanisms HPS, including dilation, angiogenesis alveolar dysfunction. The contributor transplantation only treatment that generally reverses We then discuss how disruption hepatic sinusoidal homeostasis may impact progression mainly focusing on hepatocytes, cholangiocytes, LSECs macrophages. As occurs more commonly in advanced cirrhosis, also normalisation dysfunction hypertension crucial for resolution conclusion, liver‐targeted therapies be effective treating

Language: Английский

Citations

0